Meta-analysis of the efficacy of invisible orthodontic appliances for maxillary molar distalization in adult patients / 口腔疾病防治

Objective@#To evaluate the clinical efficacy of invisible orthodontic appliances without brackets for the distal movement of maxillary molars to improve the ability of orthodontists to predict treatment outcomes.@*Methods@#Web of Science, Cochrane Library, Embase, PubMed, Wanfang Database, CNKI Database, and VIP Database were searched for studies investigating the efficacy of invisible orthodontic appliances for distal movement of maxillary molars in adult patients and published from database inception to August 1, 2023. A total of three researchers screened the studies and evaluated their quality and conducted a meta-analysis of those that met quality standards.@*Results@#This study included 13 pre- and postcontrol trials with a total sample size of 281 patients. The meta-analysis revealed no significant differences in the sagittal or vertical parameters of the jawbone after treatment when compared with those before treatment (P>0.05). The displacement of the first molar was MD=-2.34, 95% CI (-2.83, -1.85); the displacement was MD=-0.95, 95% CI (-1.34, -0.56); and the inclination was MD=-2.51, 95% CI (-3.56, -1.46). There was a statistically significant difference in the change in sagittal, vertical, and axial tilt of the first molar before and after treatment. After treatment, the average adduction distance of the incisors was MD=-0.82, 95% CI (-1.54, -0.09), and the decrease in lip inclination was MD=-1.61, 95% CI (-2.86, -0.36); these values were significantly different from those before treatment (P<0.05).@*Conclusion@#Invisible orthodontic appliances can effectively move the upper molars in a distal direction and control the vertical position of the molars. When the molars move further away, there is some degree of compression and distal tilt movement, which is beneficial for patients with high angles. The sagittal movement of incisors is beneficial for improving the patient's profile.

Scientometric Research Mapping of OMICRON for Scientific Production: A Global Perception Analysis

Background: South Africa reported a new variant of SARS-CoV-2, named 'Omicron,' to the World Health Or-ganization on November 24, 2021. Scientometric analysis quantify all currently available written communica-tion, the authors of that communication, and their citation analysis. The study's goal was to use the Scopus and Web of Science databases to look at the research metrics of Omicron publications published between Jan-uary 1965 and March 2020. Methods:All scientific research outputs with the word 'Omicron' in the title were retrieved from the Web of Science (January 1965 to March 2022) and Scopus (January 1896 to March 2022) databases on April 10, 2022. The data was analyzed based on year-wise publications; leading authors; predominant journals in publishing, highly cited articles with citations; type of publications; subject classification, frequently used keywords, geo-graphical distribution of publication, language, and more contributed institutions. Results: There were 1229 research outputs for WoS and 655 from Scopus. The number of publications for WoS increased from 22 in 1965 to 265 in 2022, while Scopus increased from 1 in 1896 to 356 in 2022. Both the databases identified the author Yuen KY as the highest contributor; Journal of Virology and Nature as the predominant journals; the Lancet as highly cited journal; majority as original articles; frequently used key-words as 'SARS-CoV-2'; the United States of America as the most productive country; majority publication in English. The publications were mainly on the subjects Chemistry and Medicine by WoS and Scopus, respec-tively. The most productive institute was the ‘University of California Systems’ by WoS and the ‘University of Hong Kong’ by Scopus. Conclusion: The term 'Omicron' first appeared in the domain of Chemistry in the late 18th century. The growth pattern of publication was not consistent. The above research metrics will be helpful to researchers in the coming days.

Visual analysis of the treatment of non-alcoholic fatty liver disease based on Web of Science / 中国药房

OBJECTIVE To analyze the current status， hotspots and development trends of research on the treatment of non-alcoholic fatty liver disease （NAFLD）， providing reference for subsequent research. METHODS Searching the Web of Science database， the literature related to the treatment of NAFLD from the establishment of the database to December 31， 2022 were collected. CiteSpace 6.1.R6 was used to construct a visual atlas， perform collaborative network analysis on authors， countries and institutions， and conduct keyword co-occurrence， clustering and emergence analysis to explore its research status and hotspots. RESULTS A total of 3 882 articles were included， and the number of publications had been increasing year by year. The top three countries in terms of publication volume were China， the United States， and Japan. The author with the highest volume of publications was Sanyal from the United States （37 articles）， while the institution with the highest volume of publications was the University of California， San Diego （75 articles）. A closely connected research team abroad mainly conducted large-scale randomized controlled trials （RCT） to evaluate the effectiveness and safety of various interventions， including medication and lifestyle， in treating NAFLD. However， domestic researches mainly focused on basic researches about the treatment of NAFLD with effective medicinal ingredients， and were characterized by traditional Chinese medicine. There were relatively few high-quality large-scale RCT studies related to it. Keyword analysis showed that researches in various countries mainly focused on regulating liver oxidative stress and inflammation， improving the overall balance of glucose and lipid metabolism. Except for hypoglycemic drugs， drugs that act on various comprehensive metabolic homeostasis targets in the body had entered clinical research， and had enormous therapeutic potential. CONCLUSIONS The research on NAFLD treatment continues to grow in popularity and tends to research targets and drugs for regulating systemic metabolic homeostasis. As the main force of research， China should strengthen communication with the international community， grasp the trends and directions of basic research， attach importance to clinical research， and continuously tap the therapeutic potential of traditional Chinese medicine.

Visual analysis of social isolation studies on adolescents based on Web of Science / 上海预防医学

ObjectiveTo perform visual analysis of the literature in the field of adolescent social isolation in order to provide reference for research on social isolation of Chinese teenagers. MethodsLiterature related to adolescent social isolation was retrieved from the Web of Science core collection database from September 2013 to September 2022. CiteSpace 6.1.R3 software was used to conduct bibliometric analysis on publication volume， publication organization， keyword clustering， keyword salience， and time⁃line map of hot words. ResultsA total of 1 347 related articles were screened out， and the overall number of publications from 2013 showed an upward trend. The largest number of articles came from the United States with 521 （38.68%）， and China ranked 6th with 79 （5.86%）. The top three institutions were Columbia University in the United States （29 articles）， King's College London in the United Kingdom （28 articles） and the University of London in the United Kingdom （27 articles）. Research hotspots mainly focused on social isolation， physical and mental health， loneliness， quality of life and comprehensive interventions. ConclusionIn recent years， the problem of adolescent social isolation has attracted continuous attention from foreign scholars. Based on our national conditions， we should conduct relevant screening and preventive assessment for social isolation of special youth groups， so as to conduct early management and intervention.

Analysis of the Development Trend in Forensic Odontology Based on CiteSpace / 法医学杂志

OBJECTIVES@#To realize the dynamic visualization of forensic odontology based on the bibliometrics methods, and capture the research hotspots and identify the future development trend.@*METHODS@#Literature articles published from January 1995 to December 2020 were searched according to specific subject words in the core data set of Web of Science. The visualization analysis of publishing country, institution, discipline, author, co-cited journal and keywords was performed by CiteSpace 5.7.R5W software.@*RESULTS@#The annual analysis of publications showed an upward trend of forensic odontology research literature year by year, with the number of annual publications more than 110 in the last five years. Developed countries were the main source of contributions and the average centrality was greater than 0.2. The research of forensic odontology involved multiple disciplines, including stomatology, biology, computer science and medical imaging, with a distinct interdisciplinary feature. A total of 115 nodes were obtained by keyword cluster analysis. The principal line of forensic odontology mainly included individual identification and age estimation and the emergence of hotspots was closely related to new technologies. Population-based odontology investigation, improvement of traditional dental age estimation method and dental age estimation based on new technology were popular research in forensic odontology.@*CONCLUSIONS@#Developing countries urgently need to increase the focus on related research. It may be an important direction for the development of forensic odontology to establish and enrich the regional dental database, develop new odontology identification technology combined with frontier and high-end technology, and develop the identification program based on advanced information technology.

Web of Science como herramienta de investigación y apoyo a la actividad científica: luces y sombras de sus colecciones, productos e indicadores / Web of Science as a research tool and support for scientific activity: lights and shadows of their collections, products and indicators

Resumen Se realiza una descripción de las colecciones, productos e indicadores bibliométricos de Web of Science, con especial énfasis en su utilidad e importancia en actividades de evaluación científica. Se exponen además sus principales limitaciones de cobertura y de indicadores, que impactan en el análisis de la producción científica en países y/o regiones periféricas y en áreas del conocimiento con menor representación en la fuente. También se comentan los aportes específicos de la base de datos en las distintas actividades y fases de la investigación científica como investigadores, revistas, grupos editoriales y bibliotecas. En concreto, se muestra el volumen de datos, se detallan sus colecciones, productos e indicadores, junto a la valoración de algunos aspectos en lo positivo y negativo. Se realizan comparativos con otras fuentes de información existentes en el mercado de la investigación científica y que igualmente permiten la realización de investigación bibliométrica, brindando al lector una importante caracterización de la herramienta y sus competidores, que ayude a conocer sus perspectivas de uso dentro del escenario de investigación. Las ideas desarrolladas y sistematizadas en el texto, permiten concluir que, a pesar de la relevancia de la misma para la actividad científica en distintos niveles y agregados, los sesgos de sus indicadores, la imposibilidad de acceso a la fuente en muchas instituciones y la existencia de otras herramientas con similares prestaciones y facilidades de uso, son aspectos que se deben tener en cuenta porque inciden en su aplicación, uso futuro y permanencia en el ecosistema de investigación.

Abstract A description of the collections, products and bibliometric indicators of Web of Science is made, with special emphasis on its usefulness and importance in scientific evaluation activities. The main limitations of coverage and indicators, which have an impact on the analysis of scientific production in peripheral countries and/or regions and in areas of knowledge with less representation in the source, are also discussed. The specific contributions of the database to the different activities and phases of scientific research, such as researchers, journals, publishing groups and libraries, are also discussed. Specifically, the volume of data is shown, its collections, products and indicators are detailed, together with the evaluation of some positive and negative aspects. Comparisons are made with other sources of information existing in the scientific research market, which also allow bibliometric research to be carried out, providing the reader with an important characterization of the tool and its competitors, which helps to know its perspectives of use within the research scenario. The ideas developed and systematized in the text lead to the conclusion that despite its relevance for scientific activity at different levels and aggregates, the biases of its indicators, the impossibility of accessing the source in many institutions and the existence of other tools with similar features and ease of use, are aspects that should be taken into account because they affect its application, future use and permanence in the research ecosystem.

Un análisis bibliométrico del concepto "Novel Foods" en publicaciones de investigación entre 1997 y 2020

RESUMEN En Europa se consideran como "Novel Foods" cualquier alimento producido con nuevas tecnologías y sustancias, así como los que no se hayan utilizado para el consumo humano en un grado significativo dentro de la UE antes del 15 de mayo de 1997. Este artículo presenta una revisión general de las publicaciones relacionadas con Novel Foods, mediante un análisis bibliométrico utilizando información extraída de Web of Science (WoS) entre 1997 y 2020. La revisión identificó a los autores más citados y productivos, así como a los principales países y revistas que realizan publicaciones. Los resultados se exponen en tablas y gráficos, además se incluye un mapeo bibliométrico obtenido con el programa VOSviewer. Entre los países con mayor número de publicaciones y citaciones se encontró Estados Unidos, Inglaterra y Países Bajos; mientras que entre los autores más productivos se encontró a Naska A. (Grecia), Siani A. (Italia) y Turck D. (Francia). Este trabajo puede orientar a diversos académicos que deseen realizar investigaciones en este campo junto con otros investigadores de diferentes países e instituciones.

ABSTRACT "Novel Foods" are any foods produced with new technologies and substances, as well as those that have not been used for human consumption to a significant degree. This article presents a general review of publications related to "Novel Foods", through a bibliometric analysis using information extracted from Web of Science (WoS) between 1997 and 2020. The review identified the most cited and productive authors, as well as the main countries and journals publishing. The results are presented in tables and graphs, and a bibliometric mapping using the VOSviewer program is also included. The countries with the highest number of publications and citations were the United States, England, and Netherlands; while among the most productive authors were Naska, A. (Greece), Siani, A. (Italy) and Turck, D. (France). This work may provide guidance to academics who wish to conduct research in this field together with other researchers from different countries and institutions.

Development trend and research hotspots and frontiers of RBC storage lesion based on CiteSpace / 中国输血杂志

【Objective】 To explore the research status, hotspots, development trend and frontier of RBC storage lesion. 【Methods】 The Web of Science core collection database (http: //webofscience.com) was used to retrieve the documents related to " red blood cell storage lesion" from 2005 to 2021. After the exclusion of unrelated documents, CiteSpace (CiteSpace.5.7.R2) was used for bibliometric analysis, including author (all signatories of the article), institution and country (to which the article is affiliated), journal, key words and cited literatures. 【Results】 A total of 508 literatures were included, accounting for 91.86% (508/553) of all publication concerning " RBC storage lesion" in this period. The annual growth rate of publications was 14.38%. There were 1 868 authors totally, and 39.76% (202/508) of them published more than 3 papers. D ′Alessandro A from the United States ranked first [7.68% (39/508)], Univ Colorado System and Univ Pittsburgh were the top two institutions [7.28% (37/508) and 7.09% (36/508), respectively]. The United States [53.35% (271/508)], Canada [13.19% (67/508)], the United Kingdom [6.50% (33/508)] and Switzerland [6.10% (31/508)] were the top 4 countries. Keywords co-occurrence network, emergent atlas and literature co-citation cluster atlas mainly focused on mechanism research, clinical trials, improvement of RBC storage conditions and reduction of RBC storage lesion. 【Conclusion】 The most important researchers and institutions in the field of RBC storage lesion in the past 17 years were mainly from the United States and Europe. The application of metabolomics and other technologies, the mechanism of RBC storage lesion, the selection of donor diversity, and the research and development of new preservation solutions or additives are the hotspots and frontiers in this field.

Visual analysis of critical care research based on Web of Science core set / 中国实用护理杂志

Objective:To analyze the data of critical care related literatures published in Web of Science core set by knowledge map visualizing technology, and summarize the research status and hotspots of critical care.Methods:The core set database of Web of Science from January 2011 to December 2020 was searched, the extracted information was standardized and analyzed by knowledge map visualizing technology.Results:A total of 783 articles in the field of critical care were included, and the number of literatures increased year by year, among which the number of articles published in the American Journal of Critical Care(305) was the most. The United States (437) was the country with the most published literatures, and Australia was the country with the highest centrality (centrality=0.67). The number and centrality of articles published from China were at the lower middle level. There was cooperation among countries, but not close cooperation. The cooperation among authors was in the state of small aggregation and large dispersion. Cluster analysis and keyword emergence analysis showed that many aspects in the field of intensive care had been the research hotspots, among which "post intensive care syndrome" and "children′s intensive care" were the research hotspots in recent years.Conclusions:The research field of intensive care is still in the rising stage of development, and post intensive care syndrome and children's intensive care are the latest hotspots in intensive care research.

Visualization analysis of lifestyle medicine knowledge maps based on Web of Science database / 中华健康管理学杂志

Objective:To analyze the medical knowledge map of lifestyle medicine based on Web of Science database.Methods:“Lifestyle medicine” “lifestyle intervention” “lifestyle medicine strategy” and “lifestyle factor” were used as Mesh terms to search the core collections of Web of Science database. The time span was from January 1st, 2000 to December 31st, 2021. The statistical function of Web of Science database was used for bibliometric analysis, and VOS Viewer software was used for co-occurrence analysis of authors, countries, institutions, keywords, and cited literature, then the visual knowledge maps were drawn.Results:A total of 5 717 articles were included, and the number of published articles from 2000 to 2021 showed an increasing trend. The top 10 authors were from the United States (nine authors) and Finland (one author); high producing countries included the United States (2 882 papers), the United Kingdom (1 254 papers) and Australia (781 papers), and China ranked sixth (499 papers). The most productive institutions were the Union of European Research Universities (946 articles), Harvard University (677 articles), University of California (313 articles), etc. The papers are mainly published in Diabetes, Circulation, BMC Public Health, Obesity, PLoS One, Med Sci Sports Exerc, etc. Five clusters were obtained by co-occurrence of key words, which were “health status” “lifestyle intervention” “lifestyle risk factors” “exercise and weight” and “chronic disease research”. The national cooperation network involves 67 countries. Conclusions:Recently, the research on lifestyle medicine shows a rapid growth trend. The current research interests include behavioral sciences, psychology, nutrition, endocrinology and metabolism, healthcare services, internal medicine, public health, pathology, cardiovascular medicine and geriatrics. Research hotspots include chronic disease and disease burden, whole life-cycle health, nutrition and exercise intervention and behavior change.

Bibliometric analysis of publications pertaining to artemisinin resistance in Plasmodium falciparum based on Web of Science from 2011 to 2022 / 中国血吸虫病防治杂志

Objective To analyze the global literature output and citation of publications pertaining to artemisinin (ART) resistance in Plasmodium falciparum from 2011 to 2021, so as to provide insights into researches on resistance of P. falciparum to ART. Methods The publications pertaining to ART resistance in P. falciparum were retrieved from the Science Citation Index Expanded (SCIE) database in Web of Science during the period from January 2011 through May 2022. The subject, journal, country, affiliation and author distributions and citations of publications were descriptively analyzed. Results A total of 1 640 publications pertaining to ART resistance in P. falciparum were retrieved in the SCIE database during the period from January 2011 through May 2022, and the number of publications appeared an overall tendency towards a rise during the study period. These articles were published in 343 journals, and the three most productive journals included Malaria Journal (341 publications, 20.79%), Antimicrobial Agents and Chemotherapy (141 publications, 8.60%), American Journal of Aropical Medicine and Hygiene (68 publications, 4.15%), with infectious diseases (565 publications, 34.45%), parasitology (531 publications, 32.38%), and tropical medicine (517 publications, 31.54%) as the predominant subject. The three most productive countries included the United States of America (627 publications, 38.23%), United Kingdom (395 publications, 24.08%), and Thailand (294 publications, 17.94%), with total citations of 25 280, 18 622 and 15 474, respectively, and the most productive countries included Mahidol University (Thailand), Oxford University (England) and London University (England), with 234, 220 publications and 142 publications and 15 058, 15 421 citations and 6 191 citations, respectively. The three most productive authors were all from Mahidol University, with 85, 77 and 63 publications, respectively; and among the three most cited authors, two were from Mahidol University, Thailand, with 8 623 and 7 961 total citations, and one from National Institutes of Health, the United States of America, with 6 267 total citations. A total of 138 articles were published by Chinese scientists, with 3 434 total citations, and National Institute of Parasitic Diseases of Chinese Center for the Diseases Control and Prevention was the most productive Chinese institution, with 35 publications, 1 165 total citations and 33.29 citations per publication. Conclusions The literature output of ART resistance in P. falciparum was relatively high in the United States of America, Europe, and Southeast Asian countries during the period from 2011 to 2021, with a relatively high academic impact. Publications in Malaria Journal and Antimicrobial Agents and Chemotherapy are recommended to be paid much attention by Chinese scientists to understand the latest advances and extend the research interests.

Análisis bibliométrico de la incontinencia urinaria masculina. Una mirada de los últimos 20 años / Bibliometric Analysis of Urinary Incontinence. An Overview of the Last 20 Years

Introducción y Objetivo En las últimas décadas, la incidencia y prevalencia de la incontinencia urinaria han venido en aumento. Existen numerosas publicaciones sobre este tema, se han introducido nuevos dispositivos, y se hanmodificado las líneas demanejo de esta patología. El objetivo de este estudio es realizar un análisis bibliométrico de las publicaciones sobre incontinencia urinaria masculina en las revistas indexadas. Métodos Se realizó un análisis bibliométrico descriptivo de corte retrospectivo de la literatura médica disponible en la base de datos Web of Science (WOS) en relación con incontinencia urinaria masculina entre 2002 y 2020. Por medio de la WOS, se obtuvieron las variables a analizar, y se elaboraron tablas y gráficas en el programa Microsoft Office Excel 2017. Resultados Encontramos un total de 498 publicaciones en 88 revistas. Hubo un crecimiento exponencial de las publicaciones a partir de 2006. Las 3 revistas conmayor porcentaje de publicaciones fueron: J Urol, con 25,2% (125), Neurol Urodyn, con 16,5% (82), European Urology Journal, con 11,1% (55); sólo 5 de las 20 revistas con más publicaciones tuvieron un factor de impacto 3. El país que tuvomayor porcentaje fue Estados Unidos con 21,2% (105), seguido por países europeos. En América Latina, el país con mayor número de publicaciones fue Brasil, con 2,6% (13). No se encontraron estudios colombianos con esta búsqueda específica. Conclusión Este es el primer estudio bibliométrico sobre incontinencia urinaria masculina. Con el tiempo, han aumentado las publicaciones acerca de este tema, y la mayoría está concentrada en revistas de Estados Unidos y Europa. No es predominante la publicación en revistas de alto factor de impacto, y es muy baja la cantidad de publicaciones que aporta Colombia y los demás países latinoamericanos.

Introduction In the last decades, the incidence and prevalence of urinary incontinence have been increasing. There are many publications about this subject, there are new devices, and the treatment of this condition has changed with time. The objective of the present study was to perform a bibliometric analysis of the publications about male urinary incontinence in the indexed journals. Methods We performed a retrospective descriptive bibliometric analysis of the medical literature available on the Web of Science (WOS) database about male urinary incontinence between 2002 and 2020. Through the WOS database, the variables to be analyzed were obtained, and tables and graphs were created using the Microsoft Office Excel 2017. Results We found 498 publications in 88 journals. Since 2006, there has been an exponential growth in publications. The 3 journals with the highest percentage of publications were: J Urol, with 25.1% (125), Neurol Urodyn, with 16.5% (82), European Urology Journal, with 11.4% (57); only 5 of the 20 journals with the highest number of publications had an impact factor ≥ 3. The country with the highest percentage of publications was the United States with 21,2% (105), followed by European countries. In Latin America, the country with the highest number of publications was Brazil, with 2,6% (13). No Colombian studies were found with this specific research. Conclusion The present is the first bibliometric analysis on male urinary incontinence. Over time, publications on this topic have increased, and most of them are concentrated in journals from the United States and Europe. The publication in journals with a high impact factor is not predominant, and the number of publications from Colombia and other Latin American countries is very low.

Avances de la bioinformática en Costa Rica: vista retrospectiva y perspectivas / Bioinformatics advances in Costa Rica: retrospective view and perspectives

Resumen Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de América Latina, ha ido adoptando la disciplina de manera progresiva. El reconocer los avances permite determinar hacia dónde puede dirigirse el país en este campo, así como su contribución a la región latinoamericana. Objetivo: En este manuscrito se reporta evidencia de la evolución de la bioinformática en Costa Rica, para identificar debilidades y fortalezas que permitan definir acciones a futuro. Métodos: Se realizaron búsquedas en bases de datos de publicaciones científicas y repositorios de secuencias, así como información de actividades de capacitación, redes, infraestructura, páginas web y fuentes de financiamiento. Resultados: Se observan avances importantes desde el 2010, incluyendo un aumento en oportunidades de entrenamiento y número de publicaciones, aportes significativos a las bases de datos de secuencias y conexiones por medio de redes. Sin embargo, ciertas áreas, como la masa crítica y la financiación requieren más desarrollo. La comunidad científica y sus patrocinadores deben promover la investigación basada en bioinformática, invertir en la formación de estudiantes de posgrado, aumentar la formación de profesionales, crear oportunidades laborales para carreras en bioinformática y promover colaboraciones internacionales a través de redes. Conclusiones: Se sugiere que para experimentar los beneficios de las aplicaciones de la bioinformática se deben fortalecer tres aspectos clave: la comunidad científica, la infraestructura de investigación y las oportunidades de financiamiento. El impacto de tal inversión sería el desarrollo de proyectos ambiciosos pero factibles y colaboraciones extendidas dentro de la región latinoamericana. Esto permitiría realizar contribuciones significativas para abordar los desafíos globales y la aplicación de nuevos enfoques de investigación, innovación y transferencia de conocimiento para el desarrollo de la economía, dentro de un marco de ética de la investigación.

Abstract Introduction: The scientific discipline of bioinformatics has the potential to generate innovative applications for human societies. Costa Rica, small in size and population compared to other Latin American countries, has been progressively adopting the discipline. Recognizing progress makes it possible to determine where the country can go in this field, as well as its contribution to the Latin American region. Objective: This manuscript reports evidence of the evolution of bioinformatics in Costa Rica, to identify weaknesses and strengths allowing future actions plans. Methods: We searched databases of scientific publications and sequence repositories, as well as information on training activities, networks, infrastructure, web pages and funding sources. Results: Important advances have been observed since 2010, such as increases in training opportunities and the number of publications, significant contributions to the sequence databases and connections through networks. However, areas such as critical mass and financing require further development. The scientific community and its sponsors should promote bioinformatics-based research, invest in graduate student training, increase professional training, create career opportunities in bioinformatics, and promote international collaborations through networks. Conclusions: It is suggested that in order to experience the benefits of bioinformatics applications, three key aspects must be strengthened: the scientific community, the research infrastructure, and funding opportunities. The impact of such investment would be the development of ambitious but feasible projects and extended collaborations within the Latin American region and abroad. This would allow significant contributions to address global challenges and the implementation of new approaches to research, innovation and knowledge transfer for the development of the economy, within an ethics of research framework.

Trends in Research of Cancer Stem Cells: A Bibliometric Analysis Based on CiteSpace / 肿瘤防治研究

Objective To explore the research hotspots and trends in the field of CSCs through the bibliometric analysis of the literature on CSCs. Methods Based on the core database of Web of Science, CiteSpace was used to analyze the annual distribution of published articles, authors, institutions, countries, journals, citations and keywords, and to explore the frequency, centrality and clustering of key words. Results (1) A total of 8131 articles were included after screening. China was the country with the largest number of articles, and Sun Yat-Sen University was the organization with the largest number of articles; (2) The hot spots in the field of CSCs are the research of CSCs in breast cancer and pancreatic cancer, the research of CSCs sorting and identification of molecular markers ALDH and genes PTEN, Sox2, C-myc, EZH2, the mechanism of EMT inducing the production of CSCs and promoting tumor metastasis, cellular and molecular mechanisms of CSCs resistance to chemical, radiation and targeted drug attacks, Wnt/β-catenin signaling pathway and tumor microenvironment regulate the differentiation of CSCs and targeted inhibition of CSCs in the treatment of malignant tumors; (3) The research trend of CSCs is CSCs stem research-biological mechanism of CSCs-CSCs application in the treatment of cancer. Conclusion The focus and direction of CSCs research are EMT inducing CSCs to promote tumor metastasis, CSCs resisting chemical attack, mesenchymal stem cells regulating CSCs, the metabolism of CSCs, and inhibitors targeting CSCs at present and in the future.

Bibliometric Analysis of Global Research on Colorectal Cancer Based on SCI-E / 肿瘤防治研究

Objective To assess the worldwide research status and the development trend of colorectal cancer. Methods Based on the papers of colorectal cancer indexed in SCI-E database from 2000 to 2019, the year of publication, countries, institutes, sources of journals, discipline fields, highly cited papers in ESI and research hotspots were analyzed by the bibliometric method. Results A total of 160183 papers on colorectal cancer were retrieved, and the number of papers increased year by year. The top 10 countries were USA, China, Japan, Germany, the United Kingdom, Italy, South Korea, France, Netherlands and Canada. Harvard University in the USA had a significant advantage on the research of colorectal cancer. The rank of the journals, institutes and highly cited papers were absolutely dominated by USA. Global research activities on the colorectal cancer displayed the characteristics of interdisciplinary development. The research hotspots mainly focus on the gut microbiota, genetic testing, targeted therapy, immunotherapy and so on. Conclusion It is necessary to strengthen the close combination of basic research and clinical application, and carry out colorectal cancer research in interdisciplinary collaboration with clinical problems.

Bibliometric analysis on the research of the social isolation of the elderly in recent 10 years based on Web of Science database / 中国实用护理杂志

Objective:To analyze the research hotspots, research directions and future trends of social isolation of the elderly in the past 10 years, so as to provide reference for future research.Methods:The literature on social isolation of the elderly included in the Web of Science database from 2010 to 2020 was retrieved, and bibliometrics analysis was conducted on the number of literature publications, key words, countries and institutions, keyword knowledge graph analysis and keyword emergence and other aspects using science citation analysis and Citespace5.7.R3 visualization software.Results:A total of 1 178 articles were included. The document volume showed a rising tendency, The majority of them was in Britain and the United States, less international cooperation among the author, issuing agency is given priority to with university. The research focuses on the mental health of the elderly, social isolation intervention methods, risk factors, quality of life and mortality, etc.Conclusions:The phenomenon of social isolation of the elderly has become a research hotspot in the international community, while China′s research in this field is still in its infancy. Future research should draw lessons from the experience and methods of foreign research, and explore intervention methods suitable for the social isolation of the elderly in China, so as to better promote the healthy aging of the elderly.

Visual Analysis of the External Characteristics and Research Hotspots of Literatures in International Forensic Science / 法医学杂志

Objective To analyze the forensic science-related literature included in the Web of Science database in the recent decade through bibliometric methods, to provide reference for relevant research. Methods Literatures were searched in 3 ways： Subject search, Journal search and Institution search. The annual distribution, national （regional） distribution, institution distribution, journal distribution and the research hotspots of the related literatures were analyzed through Thomson Data Analyzer （TDA）, Ucinet, VOSviewer, and so on. Results A total of 49 469 related literatures were included in the recent decade. The number of literatures continued to climb year by year. The top 15 countries （regions） accounted for 78.52% of the total number of published literatures, and China ranked 5th, but ranked 12th in terms of the proportion of high-cited papers; Netherlands, Switzerland, Australia, etc. had high comprehensive influence. The number of countries （regions） that cooperated with China were 129, including the United States, the United Kingdom and Germany. The Institute of Forensic Science of Saint Mary's University, University of Sydney and Netherlands Forensic Institute had high comprehensive influence, and the related literatures were published on 6 357 journals. According to high-frequency co-occurrence network and high-cited papers, brain injury, health policy, assessment scales and models and medical imaging were selected as research hotspots. Conclusion The total number of literatures in forensic science included in international SCI increased significantly, and the influence of China's achievements needs to be greatly enhanced; the research institutions were scattered, and China's research power needs to be continuously condensed; the research hotspots in international fields are extensive, and the international participation of China in top level research needs to be strengthened.

"Library and Information Science" Literature in Web of Science: What a Decade Tells Us About Scholarly Collaboration in the Field (2007-2016) / Literatura sobre "Bibliotecología y Ciencias de la Información" en Web of Science: Qué nos dice una década sobre la colaboración académica en el campo (2007-2016)

Abstract Ensuring access to published research is increasingly important for demonstrating research impact, supporting wide readership, creating interest in collaboration, and making way for funding opportunities. This article provides a bibliometric analysis of publications from 2007-2016 in the Web of Science (WOS) database to update understanding of recent international library science research as a means of discussing research impact and scientific collaboration. The methodology is a descriptive analysis of publications retrieved from the WOS database using keywords "library science" and WOS-generated subject descriptor "Information Science & Library Science." Analysis focused on descriptive data related to our research questions including representation of countries, languages, and journals. The findings reveal that most publications are published by researchers with institutional affiliations in the United States and in English. Library and information science research continues to be strong in collaboration, but international and interdisciplinary collaborations are still low in this sample. The dataset reflects that co- and multi-authored publications have the highest WOS citation counts, reinforcing the value of scholarly collaboration. This research provides a baseline to chart future growth in Library Science research publications and collaborations.

Resumen Asegurar el acceso a la investigación publicada es cada vez más importante para demostrar el impacto de la investigación, apoyar un amplio número de lectores, crear interés en la colaboración y dar paso a oportunidades de financiamiento. Este artículo proporciona un análisis bibliométrico de las publicaciones 2007-2016 en la base de datos de Web of Science (WOS) para actualizar la comprensión de la internacionalización reciente de la investigación en el campo de la bibliotecología como medio para discutir el impacto de la investigación y la colaboración científica. La metodología es un análisis descriptivo de las publicaciones recuperadas de la base de datos de WOS, utilizando las palabras clave "Bibliotecología" y el encabezado de materia "Ciencia de la información y biblitecología" generado por WOS. El análisis se centró en datos descriptivos relacionados con las preguntas de investigación, incluida la representación de países, idiomas y revistas, así como patrones de autoría con colaboraciones internacionales, nacionales, intrainstitucionales e interdisciplinarias y recuentos de citas. Los hallazgos revelan que la mayoría de los artículos son publicados en inglés, por investigadores con afiliaciones institucionales en los Estados Unidos. Las investigaciones sobre Bibliotecología y Ciencias de la Información continúan siendo sólidas en colaboración, pero las colaboraciones internacionales e interdisciplinarias aún son bajas en esta muestra. El conjunto de datos refleja que las publicaciones de coautoría y de múltiples autores tienen el mayor número de citas de WOS, lo que refuerza el valor de la colaboración académica. Esta investigación proporciona una base para registrar el futuro crecimiento de las publicaciones y colaboraciones de investigación en Bibliotecología.

Bibliometric Analysis of Publications from Web of Science Affiliated to Health Sciences University from 2017-2019.

Bibliometrics is the use of statistical methods for analysing books, articles, and other publications. It is useful to analyse the research impact, assess the quality of research using quantitative and qualitative measures, describe patterns of publication, determine the influence of writers, describe the relationship between different writers or researches. This study was conducted to evalute the number and trends of materials affiliated to Health Sciences University published in Web of Science indexed journals.METHODSThis was a retrospective observational study. The Web of Science database was accessed through institutional Login and all published materials affiliated to Health Sciences University were searched. The file of all searched materials was exported in BibTex format, which was fed to R-Studio Application after installing the Bibliometrics package. Imported data was downloaded and bibliographic data frame was created. Basic information of publications was recorded including the number of citations, citation density, journals, publication year, authors, institution and country of origin. Results were summarized using descriptive statistics.RESULTSBibliometric analysis of publications affiliated to Health Sciences University between 2017 to 2019 generated a list of 182 articles from 75 sources which included 180 Journal Articles and 2 articles in Book Chapters. Highest number of publications were 82 in the year 2019 followed by 51 in 2017 and 49 in 2018. The Annual Percentage Growth Rate of Scientific Productions was 26.8. The publications showed total 2170 authors of which 09 were authors of ‘single-authored documents’ and 2163 were authors of ‘multi-authored documents’. The Collaboration Index of all published materials was 12.5.CONCLUSIONSThis analysis reflects on the historical perspectives of Health Sciences University publications and its progress in Web of Science indexed Scientific Medical Literature database.

Researches on Mesenchymal Stem Cells for Treatment of Spinal Cord Injury: A Visualization Analysis / 中国康复理论与实践

Results and Conclusion A total of 236 authors were included, out of whom 49 authors published more than three papers, and high-yielding authors were mainly represented by Zeng Y S and Chen L. There were 162 countries/institutions involved, out of which 85 published more than three papers. Seventy-five journals were included, out of which Exp Neurol was the one with the most articles. There were 107 key words included, and the hot words were spinal cord injury, MSCs, transplantation, bone marrow, repair, and functional recovery, which formed six cluster groups. The trend was to extract and culture progenitor cells and induce their directional differentiation; mechanism of immune regulation, anti-inflammatory and nerve regeneration in the treatment of spinal cord injury by MSCs, as well as the research of tissue engineering technology, biological materials in this field. Objective:To analyze the research status and hotspots of mesenchymal stem cells (MSCs) for treatment of spinal cord injury in the past five years. Methods:The related literatures from 2014 to 2018 in Science Citation Index-Expanded (SCI-E) of Web of Science (WOS) were included. CiteSpace software was used to analyze the cooperation relationship of authors, countries and research institutions. The keywords were taken as nodes for co-occurrence analysis, cluster analysis, dynamic frontier evolution and burst analysis. The co-citation of journals and literatures were taken as nodes for analysis, meanwhile, the visual maps were drawn and the results were analyzed.