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Objective To establish the method of fingerprint and content determination of multi-component for Xiangsha Yangwei pill by gas chromatography(GC).Methods The GC fingerprint of Xiangsha Yangwei pill was found,and the peak attribution was carried out.The contents of limonene,eucalyptol,camphor,borneol,bornyl acetate,patchouli alcohol,pogostone,and α-cyperone were determined.Results The fingerprint similarity of 56 batches of Xiangsha Yangwei pill were 0.33-0.99,28 common peaks were confirmed,and 14 known components were identified.Limonene,eucalyptol,camphor,borneol,bornyl acetate,patchouli alcohol,pogostone and α-cyperone showed good linearity within the determined ranges(14.30-286.08,24.52-490.44,16.14-322.88,9.40-187.95,15.39-307.83,25.78-515.60,19.95-398.90,and 24.87-497.30 μg·mL-1).The average recoveries were 101.20％,97.90％,93.97％,94.23％,102.94％,100.54％,99.16％,and 98.31％;with the RSDs were 2.41％,1.48％,1.65％,2.00％,1.93％,2.30％,2.07％,and 2.38％,respectively.The concentrations of eight components were 0.2-959.1,0.3-420.4,1.0-542.6,0.0-64.5,0.0-364.2,0.0-339.6,0.0-130.7,0.0-82.0 μg·g-1,respectively.Conclusion The fingerprint and multi-component determination method can be used for the quality control and evaluation of Xiangsha Yangwei pill.
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OBJECTIVE:To observe the clinical efficacy and safety of Xiangsha yangwei pills combined with lansoprazole in the treatment of spleen deficiency and qi stagnation (SSQS) type chronic atrophic gastritis (CAG).METHODS:A total of 120 patients with SSQS type CAG were randomly divided into control group and observation group,with 60 cases in each group.Both groups received routine treatment.Control group was additionally given Lansoprazole enteric-coated capsule 30 mg,once a day,on an empty stomach in the morning.Observation group was additionally given Xiangsha yangwei pills 59 g,twice a day,on the basis of control group.Both groups were treated for consecutive 4 weeks.Clinical efficacies of 2 groups were observed and compared,and TCM syndrome score and pathological integral were observed before and after treatment.The occurrence of ADR was recorded.RESULTS:After treatment,total response rate and excellent effective rate of observation group were 95.00％ and 83.33％,which were significantly higher than those of control group (86.67％ and 57.53％),with statistical significance (P＜0.05).Before treatment,there was no statistical significance in TCM syndrome score or pathological integral between 2 groups (P＞0.05);after treatment,TCM syndrome score and pathological integral of 2 groups were significantly lower than before treatment,and those of observation group were significantly lower than those of control group,with statistical significance (P＜0.05).The incidence of ADR in observation group was significantly lower than that control group,with statistical significance (P＜0.05).CONCLUSIONS:Xiangsha yangwei pill combined with lansoprazole show good therapeutic efficacy and safety for SSQS type CAG and can significantly improve clinical and pathological symptoms.
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Objective To establish a method for the determi nation of hesperidin in Xiangsha Yangwei Pill(XYP).Methods Reversed -phrase HPLC was adopted.T he sample was injected into Sep -Pak C 18 cartridge for sample purifica-tion.The chromatographic conditio ns were:Prodigy ODS(150mm?4.6mm,5?m)as analytic column,methanol -wa-ter -acetic acid(35:61:4)as mobile phase,detect wavelength a t 283nmand the flowrate being 1.0mL /min.Results The linear range of hesperidin was from0.148～1.481?g,r =0.9998.The mean recovery was 100.3%,RSD =1.5%(n=6).Conclusion This method was simple,practical,accurate and suitable for the qualit y control of XYP.