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OBJECTIVE To observe the effects of Xuesaitong soft capsule on the complement-inflammatory receptor system in patients with type 2 diabetic nephropathy. METHODS A total of 92 patients with type 2 diabetic nephropathy were divided into control group and observation group by random number table method ，with 46 cases in each group. Patients in the control group were given basic treatment programs （including low-salt and low-protein diet ，quitting smoking and alcohol ，appropriate exercise ， lowering blood pressure ，blood sugar and lipid ，etc.）. The patients in the observation group took Xuesaitong soft capsules orally on the basis of the treatment of the control group ，0.55 g each time ，3 times a day. The treatment course of both groups was 4 weeks. Compare the renal function of the two groups of patients [24 h urine protein quantification ，serum creatinine （Scr），blood urea nitrogen，glomerular filtration rate （GFR）]，fasting blood glucose ，glycosylated hemoglobin ，complement factors [C3，C5， complement factor H （CFH），C5b-9]，inflammatory factors [interleukin 1（IL-1），tumor necrosis factor α（TNF-α），IL-6，monocyte chemoattractant protein- 1（MCP-1）]，renal tubular injury markers [β2-microglobulin（β2-MG），retinol binding protein 4（RBP4）， neutrophil gelatinase associated lipocalin] levels；correlation between renal tubular damage and complement-inflammatory receptor system was analyzed in the observation group before and after treatment. RESULTS Compared with before treatment ，24 h urine protein quantity ，Scr，C3，IL-1，TNF-α，MCP-1，β2-MG and RBP 4 of 2 groups were reduced significantly after treatment ，while GFR and CFH were significantly increased ；except for C 3，the observation group was significantly better than the control group （P＜ 0.05）. C 5 of the observation group was significantly decreased after treatment and was significantly lower than the control group （P＜0.05）. There were no statistically significant 60979837。E-mail：shanght126@126.com differences in other indicators of the two groups before and after treatment and between groups （P＞0.05）. C 3，MCP-1 and TNF-α were significantly correlated with renal tubular com damage （P＜0.05），and esp ecially C 3. CONCLUSIONS Xuesaitong soft capsule can reduce renal tubular damage in patients with type 2 diabetic nephropathy and improve renal function by acting on the complement system and reducing inflammation.
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Objective To investigate the clinical effect of Xuesaitong soft capsule in the treatment of cerebral apoplexy in cerebral infarction patients.Methods One hundred and twelve patients with cerebral infarction were selected as our subjects,who were in out-patient clinic of Affiliated Hospital of Hebei United Univemity from Jan.to Sep.in 2010.The patients were randomly divided into experimemal group(84 cases) and control group(28 cases) and they were received Xuesaitong soft capsule or Ginkgo leaf capsule for 28d.To meet the program data set(PPS) and a full analysis of data set(FAS),and compared NIHSS Stroke Scale score of the measured values of the diachronic changes at 0,14,28 d and the difference before and after treatment in the treatment of two groups of patients.Statistical analysis was done by SPSS13.5 software.Results PPS and FAS analysis showed that there were no statistic significance at each time of treated section in terms of the practical change value of cerebral apoplexy measuring scale between the experimental group and control group ((PPS:F between group:0.500,0.21 8,0.012 ; FAS:F between group:0.506,0.231,0.049 ; P ＞ 0.05).The practical change value of cerebral apoplexy measuring scale decreased obviously at 0 d and 28 d after treatment.The analysis of variance of repeated measured data indicated that there were obviously statistic significance(PPS:F inner group:13.89、31.18 ; FAS:F inner group:14.80,34.04 ;P ＜ 0.05).The analysis results were concordance through FAS and PPS.Conclusion The clinical effect of Xuesaitong soft capsule for cerebral infarction patients with cerebral apoplexy is safe,and it was suggested to apply in clinic.
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Objective To observe the clinical effects of Xuesaitong Soft Capsule(XSC)on soft plaque in patients with cerebrovascular carotid atherosclerosis.Methods 240 patients with cerebrovascular carotid atherosclerosis were randomly recruited into two groups:120 patients in a conrtol group treated by conventional therapy(aspirin and simvastatin),while the other 120 patients in a treatment group were treated by conventional therapy plus XSC.Both groups received the treatment for 6 months,followed by 1 year's succedent study.Results The nature,number and size of soft plaque were apparently improved after treatment in both groups.Such improvements as subsidence of soft plaques,soft plaque turning into a hard plaque,the number of soft plaque and soft plaque volume in the treatment group were superior to the control group(t=3.525.0.01).Cardiovascular and cerebrovascular events and re-hospitalization in the treatment group were also lower than the control group(t=3.678.0.01).Conclusion XSC is efrective in the treatment of carotid atherosclerosis soft plaque and significantly decrease the incidence of cardiovascular and cercbrovascular disease.