The status and influencing factors of the dyadic coping in spouses of young and middle-age cervical cancer patients undergoing synchronous radiotherapy and chemotherapy / 中国实用护理杂志

Objective:To analyze the status of the dyadic coping in spouses of young and middle-age cervical cancer patients undergoing synchronous radiotherapy and chemotherapy, and to explore the influencing factors in bi-directional of patients and their spouses.Methods:With the convenience sampling method, a total of 150 cervical cancer patients undergoing synchronous radiotherapy and chemotherapy who were hospitalized in the Radiotherapy Department of Tianjin Medical University Cancer Institute and Hospital from March 2021 to February 2022 and their spouses were selected. A cross-sectional study was conducted by the Dyadic Coping Inventory, the Lock-Wallace Marital Adjustment Test, the General Self-Efficacy Scale, the Hospital Anxiety and Depression Scale, etc. Besides, multiple linear regression was used to identify predictors of the dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy.Results:The total score of dyadic coping, marital quality, general self-efficacy, anxiety and depression in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy were (121.69 ± 19.67), (97.23 ± 25.05), (25.13 ± 5.19), (9.98 ± 3.46), (8.19 ± 4.06) points. The scores of anxiety and depression of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy were (10.57 ± 3.60), (9.10 ± 4.12) points. Multiple linear regression analysis showed that factors of the patients′ anxiety and depression, spouse′s perception of marital quality, spouse′s general self-efficacy, changes in family relationship, family income, and period of radiotherapy were the main influencing factors ( P<0.01), which accounted for 55.7% of total variation. Conclusions:The level of dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy was medium, the marriage quality remains to be further improved,and its influence factors involved in the bi-directional of patient and spouse, including patients′ anxiety and depression, the changes of the family relationship, period of radiotherapy, spouses perception of marital quality and self-efficacy and family income. Clinical medical staff can improve the level of dyadic coping in spouses of cervical cancer patients undergoing synchronous radiotherapy and chemotherapy by improving their cognition of disease, reducing the incongruence of dyadic illness appraisals, and taking multiple measures to reduce the economic burden felt of the spouses.

The mediating effect of social support between adult attachment and family resilience in young and middle-aged patients undergoing peritoneal dialysis / 中国实用护理杂志

Objective:To explore the mediating effect of social support between adult attachment and family resilience in young and middle-aged patients undergoing peritoneal dialysis, and to provide reference for psychological health care of young and middle-aged peritoneal dialysis patients.Methods:From September 2019 to February 2022, the prospective research method was adopted to investigate a total of 100 young and middle-aged patients undergoing peritoneal dialysis by general information questionnaire, Experiences in Close Relationship Scale-short form, Social Support Rating Scale, Family Resilience Scale, respectively. Multiple linear regression and structural equation model was used to evaluate the mediating effect of social support on adult attachment and family resilience.Results:The scores of attachment avoidance and attachment anxiety in Experiences in Close Relationship Scale-short form were (46.47 ± 10.23) points and (63.67 ± 10.37) points; Social Support Rating Scale scores were (36.40 ± 7.27) points; Family Resilience Scale scores were (94.21 ± 11.40) points. There was a negative correlation of attachment anxiety and attachment avoidance with total score and each dimension score of Social Support Rating Scale and total score and each dimension score of Family Resilience Scale ( r values were -0.844--0.373, all P<0.05). Attachment anxiety and attachment avoidance had a significantly indirect effect on the family resilience of young and middle-aged peritoneal dialysis patients through social support, which showed that the mediating effect of social support accounts for 41.6% and 48.8% of the total effect. Conclusions:Social support plays a mediating role in the relationship between adult attachment and family resilience in young and middle-aged peritoneal dialysis patients, nurses can focus on social support to reduce the adverse effects of adult attachment on family resilience.

Impaired sensitivity to thyroid hormones is associated with ischemic stroke in young and middle-aged euthyroid population / 西安交通大学学报(医学版)

【Objective】 To investigate the association of thyroid indices with the prevalence of ischemic stroke in young and middle-aged euthyroid population. 【Methods】 For this retrospective study, 620 euthyroid patients aged from 18 to 65 years were divided into ischemic stroke group (n=308) and non-ischemic stroke group (n=312). The characteristics of the study population; serum thyroid indices, i.e., free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH), were collected from biochemical test results. Multivariate conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for thyroid indices and ischemic stroke. 【Results】 Compared with non-ischemic stroke group, significant differences were observed in age, gender, weight, smoking status, drinking status, history of hypertension and diabetes, SBP, DBP, FBG, TC, HDL-C, LDL-C, FT3, FT4, FT3/FT4, TFQI, and PTFQI in ischemic stroke patients (all P0.05). Logistic regression analysis revealed that lower FT3 [OR (95% CI) =0.722 (0.547~0.955) , P=0.022] and FT3/FT4 ratio [OR (95% CI) =0.723 (0.600~0.870) , P=0.001] , FT4 [OR (95% CI) =1.099 (1.011~1.194) , P=0.026] were significantly associated with an increased risk of ischemic stroke. After stratified analysis by hypertension, FT4 [OR (95% CI) =1.133 (1.021~1.257) , P=0.019] , lower FT3/FT4 ratio [OR (95% CI) =0.723 (0.600~0.870) , P=0.003] , TFQI [ OR (95% CI) =1.854 (1.026~3.350) , P=0.041] , and PTFQI [OR (95% CI) =1.871 (1.065~3.288) , P=0.029] were significantly associated with an increased risk of ischemic stroke in patients combined with hypertension, while after stratified analysis by diabetes, we only found that lower FT3/FT4 ratio [OR (95% CI) =0.730 (0.559~0.953) , 0.704 (0.536~0.944) , P=0.021] and FT4 [OR (95% CI) =1.170 (1.025~1.335) , P=0.026] were significantly associated with an increased risk of ischemic stroke in patients combined with diabetes. 【Conclusion】 FT3, FT4, and FT3/FT4 ratio are associated with an increased risk for ischemic stroke in young and middle-aged euthyroid population; TFQI and PTFQ are associated with an increased risk for ischemic stroke in patients combined with hypertension.

Investigation and analysis of muscle mass loss with obesity in 318 young and middle-aged weight loss patients / 中国医师杂志

Objective:To investigate the status of muscle mass loss with obesity among young and middle-aged weight loss patients in nutrition clinic, and to analyze the risk factors of muscle mass loss with obesity.Methods:318 cases of weight loss in the nutrition clinic of Changsha Central Hospital were investigated retrospectively. All subjects completed height and weight measurements, calculated body mass index (BMI), and measured skeletal muscle mass of limbs with Inbody 270 body composition analyzer. According to the muscle mass and body fat percentage, they can be divided into muscle mass loss combined with obesity group, simple obesity group, simple muscle mass loss group and normal group. The differences in body composition and the incidence of metabolic abnormalities between groups were compared, and the risk factors of muscle mass reduction combined with obesity were analyzed by logistic regression.Results:(1) The detection rate of muscle mass loss combined with obesity was 4.7%(15/318), including 5 males and 10 females. In addition, there were 269 cases of simple obesity, 34 cases of normal, no simple loss of muscle mass. (2) Compared with the muscle mass loss combined with obesity group, the simple obesity group had a higher proportion of family history of obesity, history of exercise and nonalcoholic fatty liver disease (NAFLD) (all P<0.05), and a lower proportion of sleep time ≥7 hours ( P<0.05). The proportion of patients with exercise history was higher in the normal group ( P<0.05). Compared with the simple obesity group, the normal group had a lower proportion of family history of obesity and NAFLD (all P<0.05), and a higher proportion of exercise history and sleep duration ≥7 hours (all P<0.05). (3) Compared with the muscle mass loss combined with obesity group, the body composition indexes of the simple obesity group were higher (all P<0.05); Compared with the muscle mass loss combined with obesity group, the height, body water, skeletal muscle mass, limb muscle mass and basal metabolism of the normal group were higher (all P<0.05), but the body fat, body fat percentage and visceral fat grade of the normal group were lower (all P<0.05). Compared with the simple obesity group, the normal group had lower body weight, body fat, body fat percentage, BMI and visceral fat grade (all P<0.05). (4) There were no significant difference in the incidence of abnormal blood pressure, blood glucose, blood lipid and uric acid levels among the three groups (all P>0.05). (5) Logistic regression analysis showed that exercise history was a protective factor for muscle mass loss ( OR=0.164, P=0.026). Conclusions:The prevalence of muscle mass loss with obesity was 4.7% in young and middle-aged overweight and obese people. These people tend to move less, sleep more. No higher incidence of metabolic abnormalities was found. Exercise was a protective factor against loss of muscle mass.

Analysis of traditional Chinese medical constitution status and its influencing factors of young and middle-aged residents / 中国实用护理杂志

Objective:To investigate the traditional Chinese medical (TCM) constitution status of young and middle-aged residents and to analyze related influencing factors.Methods:A cross-sectional study was conducted to obtain data of 1 082 young and middle-aged residents in China from April to May 2019. The general characteristic, habits, emotional status and TCM constitution types of young and middle-aged residents were been collected.Results:The number of normal constitution types was 415(38.35%, 415/1 082), and the number of biased constitution types was 667(61.65%, 667/1 082) which was dominated by qi-deficiency constitution (16.70%, 344/2 060), yang-deficiency constitution (16.17%, 333/2 060) and damp-heat constitution (15.97%, 329/2 060). The Logistic regression analysis showed that the dietary regularity, taking vigorous exercise and taking moderate exercise were the protective factors of the biased constitution types of young and middle-aged residents( OR values were 0.624, 0.704, 0.704, all P<0.05), while the female, meat-based diet, anxiety and depression were the risk factors of the biased constitution types of young and middle-aged residents( OR values were 2.009-2.568, all P<0.01). Conclusions:The biased constitution is common among young and middle-aged residents. The risk factors of biased constitution are unhealthy lifestyle, anxiety and depression,which suggest the community to develop actively interventions to adjust the lifestyle and strengthen the maintenance of mental health of young and middle-aged residents.

NMR Metabonomics Study on Serum Samples of Young and Middle-Age Hypertension Patients with Phlegm Dampness Retention Syndrome / 中国中医药信息杂志

Objective To analyze the serum samples of young and middle-aged patients with hypertension of different syndromes and healthy patients by means of metabonomics; To confirm its biomarker; To reveal the nature of phlegm dampness retention syndrome in essential hypertension. Methods The syndrome types of 34 hypertension patients were differentiated into 14 cases of liver-fire hyperactivity syndrome group, 14 cases of phlegm dampness retention syndrome group and 6 cases of yin deficiency and yang hyperactivity syndrome group. 15 healthy volunteers were selected as control group. 1H-NMR technique combined with partial least squares-discriminate analysis (PLS-DA) method was used to look for the biomarkers. And the levels of UA, TC and TG were recorded. Results The level of UA in phlegm dampness retention syndrome group was significantly higher than the other three groups (P<0.05). The level of TC in yin deficiency and yang hyperactivity syndrome group was higher and had significantly difference with the control group (P<0.05). The level of TG in phlegm dampness retention syndrome group was higher and had significantly difference with control group (P<0.05). The metabonomics study based on the 1H-NMR method could distinguish the phlegm dampness retention syndrome group from the normal control group, liver-fire hyperactivity syndrome group and yin deficiency and yang hyperactivity syndrome group. Compared with the control group, the levels of acetone, VLDL, and LDL were significantly higher and the levels of lactate, serine, glucose, methionine, alanine were significantly lower in phlegm dampness retention syndrome group; compared with the liver-fire hyperactivity syndrome group, levels of citrate, alanine, VLDL, and LDL were significantly higher and the levels of glucose, lysine, glutamate, proline lactate were significantly lower; compared with yin deficiency and yang hyperactivity syndrome group, the level of creatinine was significantly higher. Conclusion There are lipoprotein metabolism, amino acid metabolism and glucose metabolism disorder in the young and middle-age hypertensive patients with phlegm dampness retention syndrome.

Study of carotid artery ultrasonography in young and middle-aged patients with cerebral infarction / 临床神经病学杂志

0.8 mm) of carotid artery in patient group (42.3%) were more than those in control group (7.4%)((P45 yrs).Conclusion Cerebral infarction in young and middle-aged patients is closely related to atherosclerosis of carotid artery.