RESUMO
OBJECTIVE: To compare the clinical and economical effects of foscarnet and a - interferon in treating chronic hepatitis B.METHODS:90 cases were randomly divided into two groups.Group A,foscarnet in a dose of 2.4g,i. v. ,b.i .d . for 1 month . Group B, a - interferon in a dose of 3 million units, im, q . d . for 3 months . The clinical effects were observed and evaluated with pharmacoeconomic cost - effectiveness analysis .RESL LTS In improving symptoms and liver function, two therapeutic regimes presented similar effect.But lower expenses were costed in unit effect of decreasing ALT in group B.In clearance of virus index, group A showed better effects and costed lower expenses in unit effect of HBeAg negative conversion. CONCLUSION: Both foscarnet and a-interferon presented fairly good therapeutic effect for chronic hepatitis B.In improving liver functions, two preparations showed similar clinical effect but a - interferon presented better economical effect. In antiviral efficacy,foscarnet showed better clinical and economical effects.