Impacts on hepatorenal functions and the blood indexes for practitioners occupationally exposed to acrylonitrile / 上海预防医学

Objective To investigate the health effects on practitioners occupationally exposed to acrylonitrile and to provide scientific bases for the study of toxicological effects of acrylonitrile on human bodies. Methods 465 medical practitioners exposed to acrylonitrile and ( a control group of ) 488 medical practitioners unexposed to acrylonitrile were selected .Age, smoking habits , alcoholic habits and other relevant factors are well-considered in selecting these two groups and all of them had lived in Ningbo for at least three years .Blood samples were collected to measure the level of Alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST ) , alkaline phosphatase ( ALP ) , pancreatic acyl transferase (GGT), total bilirubin (STB), blood urea (UREA), blood uric acid (UA), serum creatinine (SCr), total protein ( TP ) , albumin ( Alb ) , globulin ( Glb ) , ratio of Alb to Glb ( A/G ) , white blood cell ( WBC ) , red blood cell ( RBC ) , platelet ( PLT ) and hemoglobin ( Hb ) .These serum biochemical indices of the two groups were compared to find the differences thereof and to examine the effect of work years on various above-mentioned indices for medical practitioners exposed to acrylonitrile . Results The levels of ALT(t=-2.77,P=0.006), AST(t=-5.74,P<0.001), UREA(t=3.51,P<0.001), UA (t=-3.51,P<0.001)and SCr(t=-7.62,P<0.001)for medical practitioners exposed to acrylonitrile were all significantly higher than those for the control group; however, the levels of ALP(t=18.87,P<0.001), Alb(t=6.92,P<0.001), Glb(t=7.99,P<0.001), A/G(t=11.93,P<0.001), and WBC (t=4.48,P<0.001) were all lower than those for the control group , with the exposure time exhibiting positive correlations with ALT(r=0.564,P<0.001)and AST(r=0.493,P<0.001). Conclusion Acrylonitrile has certain health effects on the hepatorenal function as well as the routine blood test results of medical practitioners occupationally exposed to acrylonitrile .

Determination of acrylonitrile in injection molding process: data analysis and recommendations / 中华劳动卫生职业病杂志

Objective@#To investigate whether the identification of acrylonitrile, an occupational hazard factor for the industry of injection molding and plastic products, reported in literature is reasonable, and to put forward some recommendations.@*Methods@#Professional articles published from 1990 to 2016 were searched, and an analysis was performed for the data on the determination of acrylonitrile in the industry of injection molding and plastic products from 2003 to 2016 in Longhua Center for Disease Control and Prevention of Shenzhen.@*Results@#According to the literature, the detection rate of acrylonitrile was 10.7%, and the detection results did not exceed the limit.@*Conclusion@#At present, acrylonitrile may not be used as a routine test item for the industry of injection molding and plastic products, in order to save manpower and material resources.

Three-dimensional finite element analysis of immediate loading mini over denture implants with and without acrylonitrile O-ring.

Aim of the study : The aim of the study was to check the stress absorbed by the bone around mini over-denture dental implant with and without acrylonitrile O-ring under two different loading conditions. The initial stress absorbed by the implant plays a significant role in the success of the immediate loading implants. Materials and Methods: A three-dimensional finite element analysis using Pro-E mechanica finite element software was used to check the stress absorbed by the bone with and without acrylonitrile O-ring. The implant and the mandible where modeled from the data obtained from C.T. scan and optical projector using reverse engineering process. Two different loading conditions of 80 N and 220 N were determined and the analysis was done. Results: The result showed at lower loads (80 N), there was not much difference in the stress absorbed by the cancellous bone with or without acrylonitrile O-ring, but at higher loads (220), there was difference in the stress absorbed by the cancellous bone with (0.03508 Mpa) and without acrylonitrile O-ring (3.874 Mpa) which showed that significant stress was absorbed by the acrylonitrile O- ring. Conclusion: This study proves that higher loads during parafunctional movement were absorbed by the acrylonitrile O-ring increasing the success of the implants.

Effect of Acrylonitrile on Proliferation and Differentiation of Mouse Lung Fibroblasts in Vitro / 环境与健康杂志

Objective To approach the effect of acrylonitrile (ACN) on the proliferation and differentiation of the lung fibroblasts of mice. Methods The purification and primary culture of the lung fibroblasts(LFb)of new born mice were conducted. The cells were treated with ACN added in the medium at the varying doses of 0.01, 0.5, 1.0, 10.0, 50.0, 100.0 and 200.0 ?g/ml. The cytomorphological methods were used, the protein, malonaldehyde (MDA) and the activity of superoxide dismutase (SOD) were determined. Results No inhibitted effect on the lung fibroblasts was observed at the doses of 0.01-10.0 ?g/ml. At the doses of 50.0-200.0 ?g/ml, acrylonitrile could inhibit the differentiation and proliferation of the cells, the volume of cells became small,the rate of cell clusters decreased, at the doses of 10.0-200.0 ?g/ml, the content of protein and the activity of SOD decreased, MDA content increased. Conclusion Acrylonitrile can inhibit the proliferation and differentiation of the lung fibroblasts in mice, protein synthesis inhibition and lipid peroxidation are considered as the related factors.