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0.05),respectively.Conclusions Sodium channel blocker procainamide results in a similar repolarisation prolongation in the epicardium,midmyocardium and endocardium of the left ventricle.
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Aim To investigate the effect of carbachol on ventricular repolarization in an intact animal heart.Methods In 4 sheep,carbachol was injected to the left circumflex coronary artery(LCX) at 1.0 mol?L~(-1) and 2.5 mol?L~(-1) respectively.Multiple unipolar ECGs were acquired from the epicardium of the LCX territory.Activation-recovery interval(ARI) was analysed from these ECGs.Administration with 2.5 mol?L~(-1) was also repeated after pre-treatment with nitro-L-arginine(20 mg?kg~(-1)),a nitric oxide synthase inhibitor.Results Intracoronary injection with carbachol at 1.0 mol?L~(-1) or 2.5 mol?L~(-1) increased ARI by(38?17) ms and(58?14) ms,respectively(P