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Journal of Sun Yat-sen University(Medical Sciences) ; (6): 739-746, 2019.
Artigo em Chinês | WPRIM | ID: wpr-817750

RESUMO

@#【Objective】To investigate the effects of Tc17 cells on disease severity and elimination of HBV-DNA in patients with HBV related acute-on-chronic liver failure(HBV-ACLF).【Methods】Forty-three patients with HBV- ACLF were enrolled. Twenty patients with chronic hepatitis B(CHB)and 12 healthy subjects(NC)were enrolled as controls. Flow cytometry was used to detect the expression of peripheral Tc17 cells. HBV-DNA loads were measured,and the MELD,MELD-Na,CLIF-C ACLF and AARC scores were used to evaluate the disease severity. The effects of Tc17 cells on disease severity and decline of HBV-DNA were analyzed.【Results】Compared with NC group and CHB group, the expression of Tc17 cells in HBV-ACLF patients was significantly increased(P < 0.001 and P = 0.017). Correlation analysis showed that Tc17 cells were positively correlated with AARC score,MELD score and MELD-Na score(r = 0.504,P = 0.001;r = 0.417,P = 0.005 and r = 0.382,P = 0.012),and a correlated trend was found with CLIF-C ACLF score(r = 0.294,P = 0.055). And as the disease progressed,the expression of Tc17 cells gradually increased.In addition,Tc17 cells were positively correlated with HBV-DNA levels(r = 0.339,P = 0.026)at baseline,and the HBV-DNA levels were significantly decreased in patients with higher expression of Tc17 cells than in lower group after 4 weeks of treatment(P < 0.001). Furthermore,it was found that baseline Tc17 cells and AST levels were associated with the HBV-DNA decline by multivariate linear regression analysis.【Conclusion】Tc17 cells-mediated inflammatory response helps clear the HBV-DNA,but excessive inflammatory response may aggravate the disease severity.

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