A Case Report of Acute Encephalopathy by Aluminum Intoxication with Subdural Hematoma in End Stage Renal Failure / 대한신장학회잡지

Despite of the improved water purification system, the decreased use of aluminum based phosphate binding gels and periodic determination of serum aluminum levels, aluminum accumulation cannot be eliminated. We experienced a case of acute encephalopathy in aluminum intoxication with subdural hematoma presenting myoclonic jerk and mental change in a end stage renal failure. She was treated succesfully with low dose DFO treatment for 3 month.

Effects of SSF on memory deficits in aluminum toxic mice / 中国药理学通报

Aim To study effects of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi(SSF)on learning and memory deficits, automatic dyskinesia, neural and hepatic pathological changes and free radicals abnormal alterations.Methods Aluminum toxic model of mice was produced by introperitoneal injection (ip) of AlCl_3 for 50 d. Behavioral test of mice was used to examine the learning and memory ability;the number of automatic action determined the automatic dyskinesia;the neural and hepatic pathological changes were assessed by alterations of cerebral cortex and liver;MDA level and SOD activity in brain and liver were measured to evaluate free radicals.Results AlCl_3(100 mg?kg~-1 ,ip,50 d)resulted in a decreased ability of learning and memory in water maze task, lowered automatic action numbers, neuronal-hepatic-pathological changes and free radicals abnormal alterations, as compared with control group. The dose of SSF 50, 100 and 200 mg?kg~-1 significantly reversed the above pathological changes in toxic mice caused by aluminum. Conclusion SSF could reduce cognitive deficits and automatic dyskinesia, improve neuronal-hepatic-pathological changes and free radicals abnormal alterations.