RESUMO
The seco-prezizaane-type sesquiterpenes (SPS), as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers, are isolated from the genus Illicium, which have a variety of biological activities, including neurotoxicity and neurotrophic effects, etc. This review summarizes the chemical constituents and pharmacological effects of SPS, and discusses the potential trend and scope of future research.
RESUMO
Objective: To investigate the chemical constituents from the seeds of Illicium wardii. Methods: The chemical constituents were separated and purified by silica gel, Sephadex LH-20, MCI, etc. Results: Eleven sesquiterpenoids were isolated from the 95% ethanol extract in the seeds of I. wardii. Their structures were elucidated as wardinol C (1), 7, 8-epoxy-1(12)-caryophyllene-9β-ol (2), merrilliortholactone (3), 2α-hydroxyneoanisatin (4), 2, 6-dihydroxyhumlan-9(E)-3(12), 7(13), 9-trien (5), anisatin (6), pseudomajucin (7), 8α-hydroxy-10-deoxycyclomerrillianolide (8), 2α-hydroxyanisatin (9), rel-5-(3S, 8S-dihydroxy-1R, 5S-dimethyl-7-oxa-6-oxobicyclo-[3, 2, 1]-oct-8-yl)-3-methyl-2Z, 4E-pentadienoic acid (10), and phaseic acid (11). Conclusion: Compound 1 is a new one, and the other compounds are isolated from this species for the first time.