RESUMO
OBJECTIVE:To study the anti-thrombotic,choleretic and anti-ulcerous actions of Rhizoma Ligustici METHO_DS:Experiments were carried out on conventional models of choleresis and ulceration,and on a thrombotic model of using direct current continuously to stimulate the unilateral carotid artery of anesthetic rat RESULTS:Alcoholic extract of Rhizoma Ligustici 3g herb/kg and 10g herb/kg id or ig,increased choleresis and prolonged the time for arterial thrombosis induced by electric stimulation in rats,but did not prolonged coagulative time,PT and KPTT The extract 5g herb/kg and 15g herb/kg ig,inhibited the formation of gastric ulcers induced by water immersion,stress,HCl and indomethacin-alcohol in mice CONCLU_SION:Rhizoma Ligustici has anti-thrombotic choleretic and anti-ulcerous actions
RESUMO
OBJECTIVE:To study the analgesic,anti-inflammatory and anti-thrombotic effects of Rhizoma Cynanchi Stauntonii.METHODS:Experiments were carried out on conventional mouse models of inflammation and pain,and on a thrombotic model of using direct current continuously to stimulate the carotid artery on one side of the neck of anesthetic rat.RESULTS:Alcoholic extract of Rhizoma Cynanchi Stauntonii,in dosages of 5g herb/kg and 15g herb/kg ig,prolonged the latent period of tail flip response to hot water stimulation and reduced acetic acid-induced writhing frequency,and inhibited xylene-induced swelling of the ear and carrageenin-induced swelling of the planta.The extract,10g herb/kg ig,prolonged in vivo coagulative time and thrombotic time induced by electric stimulating artery in rats.CONCLUSION:Rhizoma Cynanchi Stauntonii has analgesic,anti-inflammatory and anti-thrombotic effects.