Comparative Study Of Commonly Practiced Atropinization Regimens In Acute Organophosphorus Compound Poisoning

Aim of the study:Effect of atropinization with different methods.Outcomes in terms of duration of hospital stay and patients recovery. Methodology: An open-label randomized clinical trial was conducted in, Shri B M Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka. 108 individuals with OPC poisoning .We compared two groups that used a titrated dosing protocol based on a structured monitoring sheet for atropine infusion with anoth-er group using an ‘ad hoc’ regime. The aim was to compare the efficacy and safety of conventional bolus doses with individualized incremental doses of atropine for atropinization followed by continuous atropine infusion for manage-ment of OPC poisoning.Result: Out of 108 patients, 54 patients received conventional bolus dose atropine (group A) and 54 patient received rapidly incremental doses of atropine followed by infusion (group B).36 subjects analyzed in group A and 32 in group B for moderate to severe poisoning. The mortality in group A was 11.1%(4/36) and in group B was 6.3%(2/32).The mean duration of atropinization in group A was 5.8hrs (348) in minutes compared to time 26.9minutes for group B. Conclusion: Administration of atropine using a fixed algorithm is easy and effective in providing the atropine requirement in management of early phase of acute OPC poisoning. Rapid incremental dose atropinization followed by atropine infusion reduces mortality and morbidity from OPC poisoning and shortens the length of hospital stay and early recovery .Incremental atropine and infusion should become the treatent of choice for OPC poisoning.

Changes of visual development in critical period produced by monocular chronic atropinization in rats / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To investigate the changes of visual development produced by monocular atropinization in rats. METHODS: Twenty normal SD rats were randomly divided into two groups: control group ( n = 10 ) and atropinization ( experimental) group ( n=10 ) . All the left eyes were selected as the experimental eyes, and the right eyes served as the normal eyes. The left eyes in atropinization group was produced by 1% atropine, 3 times a day and the right eyes in control group was treated with normal saline, 3 times a day. The flash visual evoked potentials ( F-VEP ) and retinoscopy refraction of the rats'both eyes were detected at five time points:0, 7, 14, 21, and 28d after atropinization, respectively. After 28d, six rats were randomly selected from both groups and each group had three rats. The expression of the c- fos mRNA was observed in both visual cortexes. Another six rats were chosen for the same test after 2d dark environment with 2h light later. The expression of c-fos mRNA was detected again. RESULTS: After 14d anisometropia was observed in experimental group, the difference was 3. 9D ( P 0.0 5 ) , F-VEP P1 wave of the rats left in experimental group was reached to 88. 9±1. 889ms at 21d, there was statistical difference compared with the right eye ( PCONCLUSION: In the critical period of visual development, monocular chronic atropine in rats can form anisometropia, may delay the transmission of the optic nerve, hinder the normal development of the visual cortex. Monocular atropinization in rats can be used as the model of anisometropia.

Early Resolution of Convergence Spasms Following the Addition of Antipsychotic Medications

We report a case of early resolution of convergence spasms following the addition of antipsychotic medications and present it as a possible alternative to the conventional treatment for convergence spasms. The cessation of atropinization of the eyes and the use of reading glasses was achieved after only 2 months following the initiation of antipsychotic medications for childhood emotional disorder.

Comparison with Cycloplegic Refraction after Single-dose At ropinization and Three-day At ropinization at Esotropic Children

We compared cycloplegic refraction after convenient, less toxic single-dose atropinization with conventional three-day atropinization in esotropic children. We examined sixty children below eight years of age with esotropia. Their eyes were examined by cycloplegic refraction at 90 and 120 minutes after administering a drop of atropine twice at five minutes interval. After eight applications for three days, we performed cycloplegic refraction of their eyes. In the two groups, spherical equivalent and spherical power were statistically significantly different, and it had no statistical significance between the measurement of single-dose atropinization plus 0.5 diopter and three-day atropinization. The side effects were found lesser in single-dose application than conventional three-day applications. The results showed that single-dose atropinization can be substituted for conventional three-day atropinization in clinical practice.