Effect of Aerobic Exercise on Behavioral Function in Rats with Cerebral Small Vessel Disease / 中国康复理论与实践

Objective:To explore the effect of aerobic exercise on behavioral function in rats with cerebral small vessel disease and its mechanism. Methods:Eight-week-old male Sprague-Dawley rats were randomly divided into sham group (n = 16), model group (n = 16) and swimming group (n = 16). The model was developed with bilateral common carotid artery ligation. They were assessed with burrowing test after four weeks of swimming exercise. The levels of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) protein in hippocampus were detected with Western blotting. The development of dendrites and synaptic spines in hippocampal neurons was observed with Golgi staining. The expression of Ki67, doublecortin (DCX) and Neun in hippocampal dentate gyrus was detected with immunofluorescence. Results:Compared with the model group, the burrowing ability improved in the swimming group (P < 0.05), with increase of levels of BDNF and TrkB in hippocampus (P < 0.05), Ki67/DCX and Neun positive cells in hippocampal dentate gyrus (P < 0.05), and extension of dendrites and length of synaptic spine in hippocampal neurons (P < 0.05). Conclusion:Aerobic exercise may promote the proliferation and differentiation of hippocampal neurons through BDNF/TrkB signaling pathway, expression of Ki67/DCX and Neun and development of hippocampal neurons, to improve behavioral function in rats with cerebral small vessel disease.

Behavioral Effect on Workers in Public Places of Different Environmental Quality / 环境与健康杂志

In this paper,the behavioral effects on workers in public places of different environmental quality were studied-172 workers of three public places were selected,and the values of environmental quality were determined 1.226,0.948 and 0.876.The results showed that statistically significant differences were found in average reaction time and the fastest reaction time among the three groups,environmental quality being one of risk factors,and that most scores of tests in three groups corresponded to the values of environmental quality and a significant correlation existed between some scores and the values of environmental quality