Regioselective N-Acylation of Heterocyclic Amines Under Dry Conditions Catalyzed by a Natural Clay

An environment friendly, general, rapid, and one-pot convenient procedure for N-acylation (acetylation and benzoylation) of nitrogenous heterocyclic compounds have been reported using stoichiometric amounts of heterocyclic amines and acetyl chloride or benzoyl chloride under solvent-free conditions catalyzed by a naturally available reusable clay (clay used by the traditional potters of Assam, India) at room temperature. The general efficiency of the method is evident from the variety of the N-based heterocycles, including both five and six membered rings, resulting in the corresponding N-acyl heterocycles, which react in excellent yields (69-97%) within a very short time (4-35 mins.).

Synthesis, characterisation and biocidal studies of some hydroxamic acids.

The synthesis and characterization of a series of hydroxamic acids derived from benzoylation or acylation of substituted aryl hydroxylamine or hydroxylamine hydrochloride are reported. Elemental analysis, 1H NMR, 13C NMR, and IR spectral data of the compounds are discussed. All the compounds have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.