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Objective: Role of 0.01% atropine in progressive myopia in children. Material and methods: After getting approval from the ethical committee of the Government medical college kota, we conducted a prospective study of 50 children from march 2021 to march 2022 for progressive myopia (>0.5 D/year) out of which 25 children got treatment in form of topical atropine 0.01%. The effectiveness of the drug was evaluated by calculating SE (Spherical Equivalent) at every visit. Mean change in SE was calculated before treatment and after treatment and a comparison of both the mean values was done for the efficacy of the drug. Results: Out of 25 treatment groups, 14 were males and 11 were females. There was 13 male and 12 female in the control group. The mean age was 9.7 years ± 2.3 years (range 5 years-14 years) and 12.1 years ± 2.9 years (6 years-16 years) in the atropine and control groups respectively. At baseline mean SE was found to be -2.9 ± 0.149 and -2.63 ± 0.268 whereas Best Corrected Visual Acuity (BCVA) was 0.438 ± 0.067 and 0.65 ± 0.14 in the atropine and control group respectively. The rate of myopia progression in study participants. The mean progression rate was found to be lower in the atropine group when compared before and after treatment (-0.97 ± 0.055 versus -0.23 ± 0.018). It was found to be 0.23 D/year which is supported by various previous studies like the atom 2 study in which myopic rate progression was 0.42 D after 12 months of atropine use. Conclusion: It can be concluded that 0.01% atropine eyedrops used once daily before bed can slow the progression of myopia with very good tolerance and few side effects, making it a recommended treatment to be included in our therapeutic routine.
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@#AIM:To explore the relationship between the parameters of macular integrity assessment(MAIA), best corrected visual acuity(BCVA)and macular morphology in patients with diabetic macular edema. <p>METHODS: From March 2018 to January 2020, a total of 43 patients(74 eyes)with diabetic macular edema were randomly selected for treatment in the department of ophthalmology in our hospital.To compare the relationship between MAIA micro field meter parameters and the integrity of macular external membrane, junction of inner and outer photoreceptors(IS/OS)layer and hard exudation. Pearson correlation test was used to analyze the relationship between retinal thickness and retinal sensitivity. Pearson correlation test was used to analyze the correlation between retinal thickness, retinal sensitivity and BCVA in the intact and defect groups of IS/OS layer.<p>RESULTS: Compared with the IS/OS layer defect group, the levels of BCVA(LogMAR), central retinal thickness(CRT), elliptical area of binary contour 63(BCEA63), elliptical area of binary contour 95(BCEA95)and macular integrity index(MI)in the IS/OS layer intact group were lower, and the levels of average threshold(AT)and P2 were higher(all <i>P</i><0.01), but there was no significant difference in the levels of central retinal volume(CRV)and P1 between the two groups(all <i>P</i>>0.05). Compared with the external membrane defect group, the levels of BCVA(LogMAR), CRT and MI in the external membrane intact group were lower(all <i>P</i><0.05), but there was no significant difference in the levels of CRV, AT, P1, P2, BCEA63 and BCEA95 between the two groups(all <i>P</i>>0.05). Compare the group with and without hard exudation, there was no significant difference in eye parameters between the two groups(<i>P</i>>0.05).There was a significant negative correlation between retinal thickness and sensitivity in temporal, central and nasal sides of fovea(<i>P</i><0.05), but no significant correlation in the upper and lower parts of fovea(<i>P</i>>0.05). In the complete group of IS/OS layer, AT was significantly negatively correlated with CRT and BCVA, while CRT was significantly positively correlated with BCVA(all <i>P</i><0.05). In the IS/OS layer defect group, there was a significant negative correlation between AT and BCVA(<i>P</i><0.05).<p>CONCLUSION:MAIA in the diabetic macular edema is closely related to the morphology and structure of macular area, especially the integrity of IS/OS layer and outer membrane. MAIA may be an important index to evaluate the visual function of patients with diabetic macular edema.