Stress-induced senescence of tumor cells by chemotherapy, good or bad? / 中国药理学通报

Traditionally it is believed that stress-induced senescence of tumor cells induced by chemotherapy is beneficial to inhibit tumor growth and progression, and has a positive effect on anti-tumor. However, with the longtime observation and clinical study on the anti-tumor effect of chemotherapy in the real world, it is found that tumor cells often show stronger proliferation and invasiveness after chemotherapy or relapse, tumor recurrence and refractoriness become very hot and tricky issues. So, it is necessary to rethink and explore the real process and potential effect of stress-induced senescence by chemotherapy. Here from the perspective of stress-induced senescence of tumor cells by chemotherapy, this study mainly analyzes and discusses the potential negative effects and clinical significance, so as to fully understand its pros and cons in the anti-tumor effect, hoping to provide some new ideas and rationale for improving traditional tumor chemotherapy, developing new anti-tumor drugs and coming out of the current dilemma of chemotherapy.

Tripterygium wilfordii in Treatment of Kidney Diseases and Its Toxic and Side Effect： A Review / 中国实验方剂学杂志

In recent years， with the rapid development of traditional Chinese medicine industry in China， the efficacy of Chinese medicinals in treating disease and maintaining health has been increasingly recognized. Tripterygium wilfordii， a Chinese medicinal for expelling wind， dredging collaterals， removing dampness， and relieving pain， is commonly used for treating acute and chronic glomerulonephritis， rheumatoid arthritis， and other diseases. However， the frequent occurrence of adverse reactions has limited its wide application in clinical practice. The existing studies have gradually confirmed that T. wilfordii and its active ingredients exert the bidirectional effects on kidney function. This paper reviewed the related clinical applications and articles published in the past decades and summarized the material basis for its bidirectional effects and the specific action mechanisms in renal protection and renal damage. It was found that the main active ingredients in T. wilfordii were tripterygium glycosides and triptolide， which exerted the protective or toxic and side effects on kidney by regulating immunity， influencing mitogen-activated protein kinases （MAPK） pathway， and changing the expression and function of renal transporters. Besides， the roles of administration time， dosage， and body status in the exertion of protective or toxic and side effects by T. wilfordii were also discussed. The review aimed to provide new ideas for the research on the treatment of kidney diseases with T. wilfordii and its safety application.