Detoxification of cardiotoxic traditional Chinese medicine and traditional Chinese medicine for prevention of cardiotoxicity: a review / 中国中药杂志

Cardiotoxicity is smong the main safety problems of drugs in clinical application. In recent years, traditional Chinese medicine has been gradually emphasized and studies on the evaluation of cardiac safety and prevention of cardiotoxicity of Chinese medicine have been on the rise, particularly the cardiotoxic Chinese medicine or the Chinese medicine components targeting cardiotoxicity. As for the research methods for cardiac safety evaluation of Chinese medicine, this review introduces the related clinical indexes and cell and animal models. As to the improvement of heart safety, this study reviews the material basis and mechanism of cardiotoxic Chinese medicines as well as the alleviation of cardiotoxicity by controlling the content of toxic compounds and changing dosage form, processing method, and compatibility of Chinese medicine. In addition, the effective components and mechanisms of prescriptions and active compounds in Chinese medicine for preventing and treating cardiotoxicity induced by chemotherapeutic drugs in recent years were summarized. This review is expected to serve as a reference for cardiac safety evaluation and clinical rational application of Chinese medicine.

The evaluation of the quantitative relationship between the healthy volunteers' plasma concentration after continuous administration with moxifloxacin and QTc prolongation / 中国药学杂志

OBJECTIVE: To evaluate the effect on QT interval of the healthy volunteers who was after four consecutive days of oral moxifloxacin. METHODS: The 48 volunteers (24 male and 24 female) of 20-40 years old were selected in accordance with the parameters of physical examination and laboratory test. For four consecutive days, the volunteers take oral moxifloxacin 400 mg qd. Before administration and after, ECGs were traced for each preset time point. Analysis the QT by manual measurement and measuring instruments. While, the blood samples for each preset time point were collected for the analysis of blood concentration by LC-MS/MS. At the end of a cycle do the safety checks for the healthy volunteers according to program requirements. RESULTS: The 48 healthy volunteers were selected in the trial, and 45 (22 males and 23 female) of them completed. After four consecutive days to give oral moxifloxacin qd can cause QT prolongation, the degree of risk of that is possibly dangerous. CONCLUSION: Moxifloxacin can cause QT prolongation, and the quantitative relationship between plasma concentration and QT prolongation is positive correlation, it is suggested that clinicians should pay strict attention to the administration of serious drug reactions.