Etiology and current treatment status of 277 patients with chronic atrophic gastritis and erosion in Beijing area / 中华消化杂志

Objective:To preliminarily understand the living habits, medication taking and treatment status including the therapeutic regimen, compliance and short-term efficacy of patients with chronic atrophic gastritis and erosion in Beijing area.Methods:From April to September in 2019 at Peking Union Medical College Hospital, Peking University Third Hospital and Peking University Shougang Hospital, the outpatients with chronic atrophic gastritis and erosion diagnosed with endoscopy within two weeks before visiting were prospectively included in this non-interventional observation study. Chi square test was used for statistical analysis.Results:A total of 277 patients with chronic atrophic gastritis and erosion had complete follow-up data, of which male patients accounted for 49.8% (138/277). The common initial symptoms of patients with chronic atrophic gastritis and erosion included acid reflux, abdominal distension, epigastric pain and postprandial distension, which accounted for 60.3% (167/277), 59.6% (165/277) , 58.8% (163/277) and 52.3% (145/277), respectively. For treatment, 36.8% (102/277) of the patients only received lifestyle instruction without medication. Among the patients with medication treatment, the short-term efficacy of gastric mucosal protectants+ proton pump inhibitor+ gastro-kinetic agent for abnominal distension, postprandial distention, acid reflux and nausea was highest as compared with other therapeutic regimen, and the differences were statistically significant ( χ2=25.18, 19.49, 13.75, 8.84, all P<0.05). Conclusions:Chronic gastritis with erosion may be caused by a combination of multiple factors, and the symptoms of which lack specific. If necessary, gastroscopy may help the diagnosis. Individualized treatment strategies based on the symptoms of patients is needed for treatment.

Effect of Huazhuo Jiedu formula on HIF-1α, VEGF, and PTEN in chronic erosive gastritis patients with syndrome of accumulation of turbidity and toxicity / 中国中药杂志

To observe the clinical efficacy of Huazhuo Jiedu formula in treating chronic erosive gastritis (CEG) patients with syndrome of accumulation of turbidity and toxicity, explore its mechanism by observing the changes in expression levels of hypoxia inducible factor (HIF-1α), vascular endothelial growth factor (VEGF) in serum and gastric mucosa tissues after treatment, and provide theoretical basis for the clinical application of Huazhuo Jiedu formula in treating chronic erosive gastritis. All 70 patient of CEG were randomly divided into control group and treatment group, 35 cases in each group. The patients in control group received Alatan Wuwei Wan, bid, 1 bag/time; while the patients in treatment group were given with Huazhuo Jiedu formula, 1 dose/day. The course of the treatment was 6 months in both groups. The changes in clinical symptoms, gastroscopic signs, pathology and the expression levels of HIF-1α, VEGF, and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in serum and gastric mucosa tissues were observed in both groups. The results showed that treatment group was better than control group in clinical efficacy, gastroscopic efficacy and pathological effect after treatment (<0.05); the levels of HIF-1α and VEGF in serum of treatment group were lower than those in the control group after treatment (<0.05), while the level of PTEN in serum of treatment group was higher than that in the control group after treatment (<0.05); the levels of HIF-1α and VEGF in gastric mucosa tissues in the treatment group were lower than those in the control group after treatment, while the level of PTEN in gastric mucosa tissues in treatment group was higher than that in the control group after treatment (<0.05), with statistically significant differences between these two groups (<0.05). Huazhuo Jiedu formula can improve the clinical symptoms, gastroscopic signs and pathological conditions in CEG patients with syndrome of accumulation of turbidity and toxicity, and the mechanism may be associated with decreasing the expression level of HIF-1α, VEGF and increasing the expression level of PTEN.

Study on the effect of Yangwei granules on Hp positive chronic erosive gastritis serum inflammatory factor and the negative rate of Hp / 中国生化药物杂志

Objective To investigate the Yangwei granules on Hp positive chronic erosive gastritis and inflammatory factors in the patients with HP negative rate effect. Methods 92 Hp positive patients with chronic erosive gastritis from February 2015 to June 2016 were randomly divided into control group and study group, 46 cases respectively. The control group was given Hp eradication standard scheme; the study group to Yangwei granules treatment. The levels of serum IL-2R, IL-6, TNF-α, and Hp were compared before and after treatment. Results Compared with the control group, serum IL-2R, IL-6, TNF-α alpha of the study group after treatment is lower. The negative rate of Hp in the control group was 69.57%, and the negative rate of Hp in the study group was 89.13%, (P<0.05). The effective rate of the control group was 73.91%, and the effective rate of the study group was 91.31% (P<0.05). Conclusion Yangwei granule can reduce inflammation in patients with Hp positive chronic erosive gastritis the reaction, improve the clinical efficacy and eradication rate of Hp, high safety.

Study on the effect of Yangwei granules on Hp positive chronic erosive gastritis serum inflammatory factor and the negative rate of Hp / 中国生化药物杂志

Objective To investigate the Yangwei granules on Hp positive chronic erosive gastritis and inflammatory factors in the patients with HP negative rate effect. Methods 92 Hp positive patients with chronic erosive gastritis from February 2015 to June 2016 were randomly divided into control group and study group, 46 cases respectively. The control group was given Hp eradication standard scheme; the study group to Yangwei granules treatment. The levels of serum IL-2R, IL-6, TNF-α, and Hp were compared before and after treatment. Results Compared with the control group, serum IL-2R, IL-6, TNF-α alpha of the study group after treatment is lower. The negative rate of Hp in the control group was 69.57%, and the negative rate of Hp in the study group was 89.13%, (P<0.05). The effective rate of the control group was 73.91%, and the effective rate of the study group was 91.31% (P<0.05). Conclusion Yangwei granule can reduce inflammation in patients with Hp positive chronic erosive gastritis the reaction, improve the clinical efficacy and eradication rate of Hp, high safety.

Clinical study on 48 cases of uremic maintenance hemodialysis patients with helicobacter pylori-negative chronic erosive gastritis / 中国综合临床

Objective To explore effective treatment of uremic hemodialysis patients with chronic helicobacter pylori-negative erosive gastritis.Methods Fourty-eight cases of uremic hemodialysis patients with helicobacter pylori-negative chronic erosive gastritis were diagnosed by detection of helicobacter pylori and endoscopic examination.Fourty-eight patients were randomly divided into two groups,treatment group (24 patients) with oral pantoprazole 40 mg,once a day,combinding with oral Marzulene-S particles,each 0.67 g,three times a day,the control group (24 cases ) only with the dose of pantoprazole treatment.Effect of treatment was compared in these two groups after treatment for 21 days.Results Twenty-one days after treatment,the clinical symptoms of uremic hemodialysis patients with upper gastrointestinal improved in treatment group,and the performance of endoscopic and histopathological has varying degree of improvement.It shows that pantoprazole combined with Marzulene-S treatment group has a significant effect than that single treatment with pantoprazole group.In the treatment group,the total effective rate was 95.83％,however it was 83.33％ in the control group( U =2.716,P ＜ 0.01 ).Repair of mucosal lesions were significantly different between the two groups ( total effective rate 83.33％ vs 45.83％,U =2.349,P ＜ 0.05 ).Conclusion Pantoprazole combined with Marzulene-S therapy has a significant effect on uremic hemodialysis patients with chronic Helicobacter pylori-negative erosive gastritis.

Monitoring of bile reflux for patients with chronic gastritis / 中华消化杂志

Objective To study the bile reflux in patients with different kind of chronic gastritis. Methods The changes of intragastric bile reflux during 24 h were assessed by using ambulatory bilirubin monitoring techniques in 45 patients(including 17 patients with chronic superficial gastritis, 21 with chronic erosive gastritis and 7 with chronic atrophic gastritis). Results The total time of intragastric bile reflux(%) was significantly greater in patients with chronic atrophic gastritis(16.2?18.0) and chronic erosive gastritis(14.2?12.1) than that in patients with chronic superficial gastritis(5.3?14.1, P

Investigation on Clinical Effect of Weinaian Capsules on Chronic Erosive Gastritis with HP Positivity / 中成药

Objective:To investigate the clinical effect of Weinaian Capsules on chronic erosive gastritis with HP positivity and its effect on HP.Methods: 90 patients with chronic erosive gastritis with HP positivity were divided into 2 groups. 50 cases in the treatment group were given drug Weinaian Capsules orally, 4 capsules each time, 3 times a day. 40 cases in the control group were given drug Compound Aluminum Hydroxide Tablets orally, 2 tablets each time, 3 times a day. Both groups were treated for 6 successive weeks. Results: The effective rates were 92% for the treatment group and 67.5% for the control group ( x 2=23.87,P