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Background: Children with cleft lip and cleft palate come across lot of impediment, hurdles in society. There are several social factors which hinders the proper nourishment of CL only, CP or CLP children, so majority of them tend to suffer malnutrition due to lack of standard care especially from their parents and society. Due to even low socio-economic status, impact on growth of these children is vexatious. However potential risk of malnutrition is particularly more during early childhood. Moreover, till date there are not much significant data on malnutrition in CL only, CP or CLP children. The aim of the study was to assess the prevalence of malnutrition in non syndromic CL only, CP or CLP in south India.Methods: Anthropometric parameters weight for age z score (WAZ), height for age z score (HAZ), of children with CLP were compared with age matched controls.Results: Prevalence of PEM and stunting for cleft group were 40% and 21.3% respectively compared to 33.33% and 17.33% for the control. Differences in the underweight, and stunting between the two groups were not statistically significant (?2=2.83, p value=0.58, and ?2=1.48, p value=0.69 respectively).Conclusions: There is no statistically significant difference in the occurrence of malnutrition in children with non- syndromic cleft lip and Palate compared with control.
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Objetivo: determinar la prevalencia de malformaciones asociadas en una población infantil afectada por fisuras del labio y/o paladar. Material y métodos: estudio observacional, predominantemente descriptivo, sobre 128 niños con fisuras de labio y/o paladar, nacidos en el Hospital Materno Provincial "Fé del Valle" de Manzanillo, Cuba, entre 1990 y 2011. Los datos fueron registrados sistemática y prospectivamente. Las variables utilizadas fueron: sexo, color de la piel, tipo de fisura y malformaciones asociadas. La información se resumió en base a las frecuencias, a partir de las cuales se establecieron datos de asociación intervariables y se calcularon tasas específicas de prevalencia. El riesgo de malformaciones asociadas se estimó para cada tipo de fisura a partir de la medición de la razón de posibilidades (RP) y sus intervalos de confianza del 95% (IC 95%). Resultados: la prevalencia de malformaciones asociadas en estos pacientes fue del 20,3% con predominio en el sistema osteomioarticular. Las fisuras labiopalatinas presentaron el mayor riesgo de malformación asociada (RP=2,08; IC 95%:0,83 - 5,2). Conclusiones: la prevalencia de malformaciones asociadas en esta población es concordante con las variaciones reportadas para este indicador. Aparentemente, hay un riesgo mayor de comorbilidad malformativa para las fisuras labio-alveolo-palatinas.
Objective: to determinate the prevalence of associated malformations in children with cleft lip and cleft palate. Methods: observational and descriptive study performed on 128 children with cleft lip and/or palate born at the "Fé del Valle" Maternal Hospital, in Manzanillo, Cuba, between 1990 and 2011. Data were systematically and prospectively collected. The following variables were used: sex, color of skin, type of cleft and associated malformations. Information was resumed by frequencies to establish association data and estimate prevalence rates. Risk of associated malformations was estimated for each type of cleft by means of Odds ratio and its 95% confidence intervals. Results: prevalence of associated malformations in these patients was 20,3 % with predominance of osteomioarticular anomalies. Cleft lip associated to cleft palate showed the greater risk of associated malformations (OR=2,08; 95%CI: 0,83-5,2). Conclusions: the prevalence of associated malformations in this population agrees with previous reports. It seems to be more malformations associated with combined clefts.
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La historia y el estado presente de 60 pacientes de 14-22 años de edad con fisuras del labio y paladar unilateral fue evaluado por un cirujano Máxilo facial, un Ortodoncista y un Foníatra del servicio de Cirugía Máxilo facial del Hospital Carlos Manuel de Céspedes de Bayamo. Granma. Cuba. Los resultados mostraron que más de la mitad de esos pacientes tenían integro el tratamiento por uno de los especialistas. Solo 27 pacientes (16.2 por ciento) habían completado el tratamiento por los tres especialistas. Los factores que contribuyeron a este porcentaje fueron discutidos
The evaluation of the results of an interdisciplinary team for the treatment of the unilateral cleft lip and cleft palate in Maxillo-Facial surgical service from University Provincial Hospital Carlos Manuel de Cespedes Bayamo, Granma, Cuba. The present state of 60 patients from 14 to 22 years old was evaluate by a maxillo facial surgeon, an orthodoncist and a pfoniatriciam. The results showed that more tham half of the patients had finished treatment by one of the specialist. Only 27 patients (16,2 percent) had completed treatment by the three specialist.The factors that contributed to this percentage was discussed
Assuntos
Criança , Anormalidades Congênitas/terapia , Fissura Palatina/terapia , Fenda Labial/terapia , OdontologiaRESUMO
Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common craniofacial birth defect that is the result of a mixture of genetic and environmental factors. While studies have identified a number of different candidate genes and loci for the etiology of CL/P, the results have not been consistent among different ethnic groups. To study the genetic association of the candidate genes in Korean patients affected by CL/P, we genotyped 97 nonsyndromic CL/P patients and 100 control individuals using single nucleotide polymorphic markers at the MTHFR, TGFA, and IRF6 genes. We report that the T3827C marker at TGFA showed significant association with nonsyndromic CL/P, but all the other markers tested were not significantly associated with nonsyndromic CL/P in Korean patients.
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Humanos , Fenda Labial , Fissura Palatina , Anormalidades Congênitas , EtnicidadeRESUMO
Incidence of congenital anomalies decreased due to decrease in birth rate and popularization of prenatal examination. But there has been relatively high incidence of congenital cleft lip and cleft palate among congenital anomalies. In spite of many studies, the cause of clefting has not been clarified yet. Purpose of this study is to investigate clinical status and etiologic factors of cleft lip and cleft palate. We reviewed clinical records of 1111 cases of cleft lip and palate patient who were treated with primary cheiloplasty and palatoplasty at Hanyang University Hospital from January, 1990 to December, 2002. Clinical analysis of these 1111 cases of cleft lip and palate patients were carried out and summarized as follows. The rate among cleft lip, cleft lip & palate, and cleft palate were 1.5:1.4:1. The rate among left side, right side, and bilateral were 2.5:1.5:1. Male versus Female was 1.3:1. In cleft palate group, the ratio was 0.7:1, conversely. 1st baby was most common in patient group. 5.9 % of patients had congenital anomalies. Medication was the most possible factor with cleft lip and palate in pregnancy. 6.4 % of patients had history of cleft lip or palate in their family trees. For the closure of cleft lip, Millard's rotation advancement method was most commonly used at about 3months of age. In cleft palate group, pushback palatoplasty was most popular method and the timing of surgery was at about 12-18 months of age. Based on the above data, it may be concluded that outbreaks of cleft are affected by multiple factors and that there is no significant difference of clinical status and treatment modalities between this and other investigations. To investigate the correlation between proposed factors and effects, prospective study method is more suitable than retrospective study like this. Good study design for data collection and appropriate control group are also required. For this purpose, I propose construction of new data collecting system and multi-center study for birth monitoring system.