Real-world study on syndrome distribution and medication characteristics of colonic malignant tumors / 中国中药杂志

In order to explore the characteristics of traditional Chinese medicine(TCM) syndromes and medications in patients with colonic malignant tumors in China, the clinical data of patients with colonic malignant tumors from the information system of 33 Grade-A tertiary hospitals in China from 2001 to 2016 were extracted and a descriptive analysis was conducted on their disease characteristics, syndrome distribution, drug characteristics and treatment status. A total of 22 691 patients with colonic malignancies nationwide were included in the analysis, with male to female ratio of 1.59∶1, median age of 62 years, susceptible age of 50-79 years. Postoperative patients with colonic malignant tumors accounted for 47.10%, and patients with liver metastases reached 36.02%. Among the 520 patients with colonic malignant tumors, the top three TCM syndromes were: spleen deficiency syndrome(21%), Qi and Yin deficiency syndrome(17%) and liver and stomach disharmony syndrome(15%). The most frequently used Western medicine for patients with colonic malignant tumors was anti-metabolite cytotoxicity(61.23%), most frequently used in combination with platinum-based cytotoxic drugs(support degree 42.40%).The top three Western medicines were oxaliplatin(42.26%), leucovorin injection(38.58%) and dexamethasone(34.67%). The most frequently used traditional Chinese medicine type was heat-clearing and detoxifying drugs(39.59%), most frequently used in combination with Qi replenishing and body resistance strengthening drugs(support degree 12.72%). The top three traditional Chinese medicines were compound Kushen Injection(14.62%), Shenqi Fuzheng Injection(10.18%) and Aidi Injection(6.48%). This study shows that spleen and Qi deficiency may be the dominant syndrome of colonic malignant tumor, and chemotherapy is one of the main treatment methods. Traditional Chinese medicine has shown unique advantages in alleviating the toxic and side effects of chemotherapy and preventing recurrence and metastasis, so integrated TCM and Western medicine can significantly improve the clinical efficacy.

Research on Clinical Application of Fufang Kushen Injection in Treating Colonic Malignant Tumor in the Real World / 世界科学技术-中医药现代化

This study was aimed to analyze the clinical application of Fufang Kushen (FFKS) injection in treating colonic malignant tumors in the real world based on the hospital information system (HIS) database,in order to provide references for clinical application of FFKS injection.The electronic medical records were extracted from 3328 patients with colonic malignant tumors using FFKS injection from 22 large-scale triple-A hospitals nationwide based on the data warehouse of HIS established by the Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences.The descriptive analysis of frequency and rate was made on general characteristics,diagnostic characteristics,dosage and characteristics of medication information,characteristics of drug combination,characteristics of discharge outcome and etc.The results showed that the average age of patients treated with FFKS injection for colonic malignant tumors was 61.85 years old,with more males than females.Patients were mainly hospitalized from the department of digestology and oncology.The single dose of medication was usually 10-20 ml.The main course of treatment was 4-7 days.Common clinical medications in combination included Tropisetron injection,thymus peptide injection,oxaliplatin injection,fluorouracil,leucovorin injection and etc.The total efficiency was 39.78％ based on the discharge outcomes.It was concluded that the population characteristics of using FFKS injection to treat colonic malignant tumors were clear and in line with the general rule of colonic malignant tumors.The clinical dosage and scope of FFKS injection in the real world of colonic malignant tumors treatment basically meet the medication instruction.The clinical drug combination type is more extensive.