Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells

Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 – 6 were isolated first time from this plant. Compounds 1 – 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC₅₀ value of 8.02 ± 0.06 µM.

Chemical constituents and pharmacological activities of Cyclocarya paliurus(Batal.)Iljinskaja:research advances / 国际药学研究杂志

Cyclocarya paliurus(Batal.)Iljinskaja,a Chinese native plant,contains various components of bioactive constitu-ents in leaves. The main chemical constituents are triterpenes,flavonoids,organic acids,polysaccharides,steroids,etc. and among them,the dammarane-type triterpenoids are the main sweet components. Modern pharmacological research has demonstrated that these compounds or plant extracts show hypoglycemic,lipid-lowering,blood pressure lowering,antioxidation,and antibacterial activi-ties,and so on. The research advances in chemical constituents and pharmacological effect of C. paliurus are reviewed for a prospect reference of its further development and utilization.