RESUMO
AIM: To study the effect of decanoyl acetaldehyde against atherosclerosis and the relative mechanisms in rats.METHODS: Rats were randomly assigned into 5 groups,That were the control,model,low and high dose of decanoyl acetaldehyde and ibuprofen groups.The model rats were intraperitoneally injected with 600 000 IU/kg vitamine Ds and intragastricly administrated with high-fat emulsion 10 mL/( kg·d) for 70 days.At the same time,the model rats treated with drugs were orally given 39 mg/( kg·d),78 mg/( kg·d) decanoyl acetaldehyde and 144 mg/( kg·d) ibuprofen suspension respectively.After 70 days,the rats were euthakilled,and the serum level of TC,LDL-C,HDL-C/LDL-C ,TNF-α,IL-1β,IL-6,IL-10,the expression of NF-κB in rat aorta and the pathological change in aorta were measured.RESULTS: Decanoyl acetaldehyde could lower the serum level of TC,LDL-C,TNF-α,IL-1β and IL-6.It increased the level of IL-10 and the ratio of HDL-C/LDL-C,inhibited the expression of NF-κB and reduced the thickness of the artery wall.CONCLUSION : Decanoyl acetaldehyde has an effect on anti-atherosclerosis.The mechanism may be related with inhibiting inflammation and lowering serum lipid.
RESUMO
AIM:To study the effect of decanoyl acetaldehyde against atherosclerosis and the relative mechanisms in rats.METHODS:Rats were randomly assigned into 5 groups,That were the control,model,low and high dose of decanoyl acetaldehyde and ibuprofen groups.The model rats were intraperitoneally injected with 600 000 IU/kg vitamine D_3 and intragastricly administrated with high-fat emulsion 10 mL/(kg?d)for 70 days.At the same time,the model rats treated with drugs were orally given 39 mg/(kg?d),78 mg/(kg?d)decanoyl acetaldehyde and 144 mg/(kg?d)ibuprofen suspension respectively.After 70 days,the rats were euthakilled,and the serum level of TC,LDL-C,HDL-C/LDL-C,TNF-?,IL-1?,IL-6,IL-10,the expression of NF-?B in rat aorta and the pathological change in aorta were measured.RESULTS:Decanoyl acetaldehyde could lower the serum level of TC,LDL-C,TNF-?,IL-1? and IL-6.It increased the level of IL-10 and the ratio of HDL-C/LDL-C,inhibited the expression of NF-?B and reduced the thickness of the artery wall.CONCLUSION:Decanoyl acetaldehyde has an effect on anti-atherosclerosis.The mechanism may be related with inhibiting inflammation and lowering serum lipid.