RESUMO
Introduction: Dengue is one of the most important viral diseases especially in the tropical regions. This disease increases in incidence in the immediate post monsoon period coinciding with the breeding of mosquitos in the stagnant water. It has varied clinical presentation and more or less consistent abnormal laboratory values on complete blood count test. Aim of the study: The aim of the study was to determine the clinical and hematological profile in patients with Dengue fever. Materials and methods: This was a prospective study done in the department of General Medicine at Dr. Pinnamaneni Siddhartha Institute of Medical sciences and Research Foundation, Andhra Pradesh, over duration of 7 months. The study included 60 patients admitted in the hospital and all the cases were IgM dengue positive. Results: There were 40 (66.6%) male and 20 (33.3%) female patients. Out of 60 patients, 30 (50%) were in age group of 20 to 30 years. Most of the cases were found in post monsoon period in September and October. In our study out of 60 cases of dengue fever, raised hematocrit (>47%) was noted in 10 (16.6%) of patients at presentation and 50 (83.3 %) cases had thrombocytopenia, in which 8 (13.3%) cases had < 20,000/cumm with bleeding manifestations. Conclusion: Most common clinical presentation of Dengue fever is of fever with or without myalgia and presence of hepatosplenomegaly. Young adult males are more commonly affected. The most common laboratory abnormalities are of an increase in hematocrit, low total leucocyte count and low platelet count.
RESUMO
This study observed the pattern of reported dengue infections, clinical manifestations, and circulating dengue serotypes in Negeri Sembilan, Malaysia. The aim of this study was to determine the co-circulation of the four different dengue virus serotypes in Negeri Sembilan. We analyzed the surveillance data (VEKPRO) from Negeri Sembilan State Health Department and National Public Health Laboratory, Malaysia on reported dengue infections from 1st January 2010 to 31st December 2010. There were 1466 reported dengue infections, 1342 (91.5%) cases were dengue fever (DF) and 124 (8.5%) were dengue hemorrhagic fever (DHF). The mean age was 32.2± 15.8 years old and most were young adults, aged 15 years old and older. Males (p < 0.05), and those residing in Seremban district (p < 0.05) were more likely to get dengue infections. Symptoms presented upon admission were fever (100%), headache (99.9%), myalgia and arthralgia (98.8%), rash(24.2%), petechiae (16.0%),bleeding tendencies (7.0%) and neurological deficits(1.2%). All four dengue serotypes (DEN 1 – 4) were present, the pre-dominant serotype was DEN-3, noted in January, then existed together with DEN-2 until around May. DEN-1 was the most pre-dominant circulating dengue serotype afterwards, reaching a peak in December 2010. Dengue affected all age groups particularly young adults and males. Most cases reported were in urban areas and Seremban district. Most of the dengue infections occurred in the first half of the year, with the DEN-2 and DEN-3 serotypes being the most predominant.