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The purpose of investigation is to find out the potential of Medium Molecular Weight Chitosan (MMWCH) loaded with Lincomycin Hydrochloride (LNC) having pKa 7.6 and log p value 0.20 for treatment of periodontitis and gingivitis, prepared by using solvent casting technology in form of intra pocket dental film. Four sets of formulation were prepared and each set comprises of four formulations each. The formulations were evaluated for drug content uniformity, weight uniformity, thickness of patch, surface pH, moisture loss, swelling index, water vapor transmission rate, static in vitro release studies using diffusion cell, ex vivo flux study using diffusion cell by help of excised gum lining of goat, release kinetics and Akaike Information Criteria; goodness of fit (AIC) value determination. Excipient drug interaction was carried out by using Fourier Transform Infrared spectroscopy (FTIR), and by Thermo gravimetric Analysis (TGA)/Differential thermal analysis (DTA)/Derivative thermo gravimetric analysis (DTG) and this suggests that there is no drug excipient interaction occurs. The drug release studies show the sustained release without any burst effect for consecutive 5 days. Formulation R1, R2, R7, R8, R9, R10, R13 and R14 and follows the zero order release pattern and formulation R3, R4, R5, R6, R11, R12, R15 and R16 follows the Higuchi model because they have lower AIC value and higher r2 value. Formulation ER17, ER18, ER19 and ER20 is having the average flux of 1.0, 1.48, 1.35 and 1.45 mg/cm2 hr-1 respectively, and when compared statistically student’s paired t-test these all formulations are significantly different from each other.
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Introduction Intraoral film processing can be performed manually using chambers manufactured from opaque material to prevent light from entering and consequently blurring images. The aim of this study was to evaluate whether portable darkrooms used in offices, clinics and educational institutions prevent the entry of light during the processing of intraoral films. Methods To this end, tests were carried out and images were analyzed by measuring the optical base-plus-fog densities (ODs) upon imaging. Results Review of the OD measurements revealed that in 70.7% of the evaluated manual portable revelation cameras, the base-plus-veil density of intraoral films was not in accord with that of the protocol reference. Discussion The results of this work can be used to identify chambers that are commonly exposed to light from fluorescent lamps and solar lighting.
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PURPOSE: This study was to evaluate the beam quality of intraoral X-ray equipments used at Yonsei University Dental Hospital(YUDH) using the half value layer(HVL) and the characteristic curve of intraoral standard X-ray film. MATERIALS AND METHODS: The study was done using the intraoral X-ray equipments used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. RESULTS: Most of the HVLs of intraoral X-ray equipments were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-70S model of prosthodontic dentistry department, and the REX 601 model at the student clinic were relatively low. CONCLUSION: HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion.