Penfigoide Gestacional / Pemphigoid Gestationis

Resumen 22. Las enfermedades ampollares de tipo penfigoide,se caracterizan por la presencia de ampollas de origen autoinmune.El Penfigoide gestacional(PG), es parte de este grupo de enfermedades y se define por la presencia de una erupción ampollar,intensamente pruriginosa de comienzo agudo, generalmente en el segundo trimestre del embarazo o posparto inmediato, en ocasiones puede haber compromiso fetal y asociarse con otras enfermedades de origen autoinmune.

Abstract 26. Pemphigoid-type bullous diseases are characterized by the presence of blisters of autoimmune origin.Gestational Pemphigoid (PG) is part of this group of diseases and is defined by the presence of an intensely pruritic bullous eruption of acute onset, usually in the second trimester of pregnancy or immediate postpartum period, there may be fetal compromise and associated with other diseases of autoimmune origin.

Penfigoide gestacional asociada a complicaciones en el neonato / Gestational pemphigoid complications related in the newborn

RESUMEN Durante el embarazo ocurren numerosos cambios inmunológicos, metabólicos, endocrinos y vasculares que pueden propiciar la susceptibilidad de la mujer embarazada a presentar cambios en la piel y sus anexos. El penfigoide gestacional es una enfermedad rara, autoinmune, caracterizada por una dermatosis ampollosa, muy pruriginosa, con probable afectación del producto. Se describe el caso en una paciente con penfigoide gestacional, confirmado histológicamente y se discuten su evolución, las complicaciones observadas en el recién nacido, además de realizar una revisión en la literatura.

ABSTRACT Many inmunologic changes occur During pregnancy occur, metabolic, endocrine and vascular that may promote susceptibility of pregnant women to have changes in the skin and its annexes. Gestational pemphigoid is a rare, autoimmune bullous dermatosis characterized by very itchy, with probable involvement of the product. We describe a patient with Gestational pemphigoid, histological confirmation and we discuss its evolution, the complications in the newborn, in addition to a review in the literature.

Dermatoses of Pregnancy: Clues to Diagnosis, Fetal Risk and Therapy

The specific dermatoses of pregnancy represent a heterogeneous group of pruritic skin diseases that have been recently reclassified and include pemphigoid (herpes) gestationis, polymorphic eruption of pregnancy (syn. pruritic urticarial papules and plaques of pregnancy), intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. They are associated with severe pruritus that should never be neglected in pregnancy but always lead to an exact work-up of the patient. Clinical characteristics, in particular timing of onset, morphology and localization of skin lesions are crucial for diagnosis which, in case of pemphigoid gestationis and intrahepatic cholestasis of pregnancy, will be confirmed by specific immunofluorescence and laboratory findings. While polymorphic and atopic eruptions of pregnancy are distressing only to the mother because of pruritus, pemphigoid gestationis may be associated with prematurity and small-for-date babies and intrahepatic cholestasis of pregnancy poses an increased risk for fetal distress, prematurity, and stillbirth. Corticosteroids and antihistamines control pemphigoid gestationis, polymorphic and atopic eruptions of pregnancy; intrahepatic cholestasis of pregnancy, in contrast, should be treated with ursodeoxycholic acid. This review will focus on the new classification of pregnancy dermatoses, discuss them in detail, and present a practical algorithm to facilitate the management of the pregnant patient with skin lesions.

Pemphigoid gestationis: clinical and laboratory evaluation

INTRODUCTION: Pemphigoid gestationis, also known as herpes gestationis, is a rare autoimmune blistering disease associated with pregnancy. It usually occurs during the second or third trimester, but it may be present at any stage of pregnancy or the puerperium. The clinical, histologic, and immunopathological features of pemphigoid gestationis are similar to those of the pemphigoid group of disorders. METHODS: We hereby report seven patients who were diagnosed with pemphigoid gestationis and followed at the Autoimmune Blistering Disease Clinic in the Department of Dermatology of the University of Sao Paulo Medical School between 1996 and 2008. DISCUSSION: Demographic and clinical findings, such as median age, sites of involvement, and gestational age of onset of our patients, coincide with those described in previous reports. The majority of patients (85 percent) exhibited complement C3 or C3 and immunoglobulin G (IgG) deposition along the basement membrane zone (BMZ) on immunofluorescence. Herpes gestationis factor (HG) factor was postitive in four out of six patients (67 percent), and three out of five patients recognized the bullous pemphigoid recombinant antigen (BP180) by ELISA. CONCLUSION: This study revealed a good outcome of the newborns from pemphigoid gestationis affected mothers, based on the absence of pemphigoid gestationis cutaneous lesions, mean birth weight, and normal Apgar scores and gestational age at birth.

A Case of Pruritic Folliculitis of Pregnancy / 대한피부과학회지

Pruritic folliculitis of pregnancy of pregnancy is a specific dermatoses of pregnancy which is characterized by erythematous follicular papules and pustules between the fourth and ninth month of pregnancy. It has usually resolved by 4 weeks of postpartum and has no adverse implications for mother and baby. We report a case of pruritic folliculitis of pregnancy in a 24-year-old primigravida woman who had had monomorphic erythematous follicular papules and pustules on her anterior chest wall and back. Histopathological findings of erythematous papules showed acute folliculitis and perifolliculitis. The skin lesions improved rapidly with 2 weeks of delivery without treatment.