Research progress on the relationship between Porphyromonas gingivalis and the malignancy of the digestive system and possible pathogenetic mechanism / 华西口腔医学杂志

The malignant tumors including oral cancer, colorectal cancer, pancreatic cancer, and esophageal cancer, of the digestive system are a common high-fatal malignancy. Porphyromonas gingivalis, as the most important pathogen of periodontal disease, has been gradually proved that its invasiveness occurs not only in the mouth but also in other parts of the digestive system. Moreover, the relevant pathogenic mechanism is increasingly attracting the reseachers' attention. In this study, the role and possible pathogenesis of Porphyromonas gingivalis in the digestive system are described in a systematic and comprehensive way.

Research progress on exosome-derived non-coding RNA in digestive system malignancy / 中国癌症杂志

Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various cells and widely distributed in most body fluids. Biological active substances, including non-coding RNAs and proteins, have been identified in the exosomes. Exosome may be involved in cell-to-cell substance transporting and signaling. Non-coding RNAs have important function of regulating gene expression and also play key roles in the occurrence and development of many cancers. Research on exosome-derived non-coding RNA is a new hotspot at present. In this paper, we will review research progress on exosome and exosome-derived non-coding RNA in digestive system malignancy.