Study on the pharmacokinetics of alprazolam at different dose in rats / 中国药理学通报

The pharmacokinetics of alprazolam in 18 rats was studied by using reversed-phase HPLC. The pharmacokinetic characteristics were fit to one compartment opened model after intragastric administration of alprazolam at doses of 50,20 and 2 mg ? kg-1, respectively. The absorbing and eliminating parameters between the three groups were no significant difference. Mean of Ka was 3. 3454 h-1,Ke 0. 3873h-1,T1/2Ka 0. 29 h, T1/2Ke 2.61 h, and Tmax 1.04 h. There was a positiverelationship between the serum concentration and dosage (r = 0. 6096, P