RESUMO
Objective To study the influence on common logarithm of partition-coefficient (log P) value of insoluble drugs on nano-lipid emulsion properties ,including drug-loading amount ,in vitro release ,and phase distribution etc .Methods 6 insoluble drugs ,nimodipine (NIM) ,docetaxel (DTX) ,curcumin (CUR) ,paclitaxel (PTX) ,teniposide (TEN) ,silybin (SLB) ,were selected as the model drugs ,to investigate the relationship between log P value and nano-lipid emulsion of the dissolubility in PEG400 ,the amount of drug-loading ,particle diameter ,Zeta potential ,in vitro release ,and phase distribution respectively .Results With the increase of log P value ,drug solubility in PEG400 first increased and then decreased ,drug-loading in nano-lipid emulsion increased ,release rate in vitro of drug slowed down ,drug distribution in oil phase increased while in emulsion layer decreased .Log P value has no correlation with particle diameter and Zeta potential .Conclusion The properties of drug-loading nano-lipid emulsion can be preliminarily judged by log P values and the solubility in PEG400 of drugs .