RESUMO
Dynorphin A is an endogenous opiate peptide first extracted from the pig pituitary by Goldstein in 1979.The purpose of this study was to observe the changes in dynorphin A1-13 content in the pituitary and brain areas of burned rats.Using PIA, the following results were obtained: (1)Immediately after burning, there was a significant increase of immunoreactive substance dynorphin A1-13 (ir-dyn A1-13) in the pituitary and the pontine-medullary area of the animals (P
RESUMO
The effects of arginine vasopressin (AVP) on the contents of ir-?-EP and ir-Dyn A1-13 in ischemic brain regions of Mongolian gerbils were observed with radioimmunoassay in this study.The results showed that the contents of ir-?-EP were significantly increased and those of ir-Dyn A1-13 were decreased in ischemic cortex and hypothalamus after injection of AVP into the lateral ventricle. However, the contents of ir-?- EP were markedly decreased and those of ir-Dyn A1-13 were unchanged significantly in the ischemic cortex and hypothalamus after intraventricular infusion of AVP antiserum.
RESUMO
The effects of 3 anesthetics (urethane, pentobarbital and chloraiose) on the contents of dynorphin A1-13 (ir-dyn-A1-13) in the brain, pituitary and spinal cord of male rats were studied with radioimmunoassay. Under urethane anesthesia, the contents of ir-dyn- A1-13 in the brain, pituitary and spinal cord of rats were significantly reduced. When the rats were given chloralose, the contents of ir-dyn-A1-13 were markedly reduced except in the midbrain. After the rats were anesthetized with pentobarbital, the contents of ir-dyn-A1-13 were decreased apparently except in the thalamus.