Study on the Preparation of Lingqiao Jiedu Pellets / 中国中医药信息杂志

Objective To prepare Lingqiao Jiedu Pellets. Methods Lingqiao Jiedu Pellets was prepared by extrusion-spheronization method. Formulation composition and process factors influencing physical properties, such as spherical shape degree and productivity, were optimized. And it had a film coating by fluidized bed. Results Blend the extraction with MCC, and add adequate water. And squeeze with 30 r/min and roll 6 min with the rate of 48 Hz, drying and screening. Conclusion The pellets had a good appearance and stable quality.

Preparation of Gegen Qinlian Pellets by extrusion-spheronization method / 中草药

Objective To prepare Gegen Qinlian Pellets with higher yield of drug loading and being good for industrial production.Methods The Gegen Qinlian Pellets were prepared by extrusion-spheronization.The effects of four key parameters on spheronization process were the proportion of bond,extrusion speed,spheronisation speed,and spheronisation time,which were investigated to obtain optimal formulation.Results Gegen Qinlian Pellets presented perfect sphericity and narrow diameter distribution.Drug loading in the pellets could be up to 70% and yelid over 90%.Conclusion The Gegen Qinlian Pellets are successfully prepared by extrusion-spheronization.It presents a method for industria-lized production of Chinese materia medica.

Preparation and formulation optimization of Breviscapin Sustained-release Pellets / 中草药

Object To investigate the preparation technique and optimal formulation of Breviscapin Sustained release Pellets (BSP) and the release mechanism of breviscapin from the pellets. Methods BSP was prepared by extrusion spheronization method. Based on the studies of influential factors, optimal formulation modified to release drug over 12 h was obtained by the orthogonal design. And release mechanism of breviscapin from BSP was established by equation fitting. Results Prepared BSP has such advantages as simple technique, uniformity in diameters and high loading with even contents. They can release drug for 12 h. And the release of breviscapin could be mainly controlled by diffusion associated with slight erosion. Conclusion Extrusion spheronization method is simple for the preparation of BSP, and useful for the large scale prodution.