The Role of Hemic Hypoxia in the Development of Sensorineural Hearing Loss in Children Associated with Hepatitis B

Background: Thereare not enough studies and evidenced researches conducted related to this topic. Therefore, we studied fetal haemoglobinin various somatic diseases in children with sensorineural hearing loss associated with hepatitis B.Materialsand Methods:26 children with sensorineural hearing loss associated with hepatitis B, aged from 5 to 18 years, were examined. The comparison group consisted of 8 children with sensorineural hearing loss without concomitant somatic pathology. The control group consisted of 12 healthy children. The compulsory examination plan for patients included generally accepted laboratory and instrumental diagnostic methods: complete blood count, urine, feces, Wasserman reaction, ECG.Results: Hb concentration in blood inpatient children with sensorineural hearing loss of the associated chronic hepatitis B (CHB) was reduced significantly by 58% compared with thehealthy children. In children with Sensorineural Hearing Loss (CHT) without CHB, the studied parameter decreased when compared with healthy children by 25%. Analysis of the results showed a significant increase in the level of fetal haemoglobin in the blood of children with CHT associated with hepatitis B on average by 1.5 times, indicating hypoxia.Conclusion: Dependence of the indices of partial oxygen in the blood and, to a greater extent, HbF, on the blood content of the vasoconstrictor endothelin-1, von Willebrand factor, indicates the pathogenetic significance of the leading markers of endothelial dysfunction in the development of tissue hypoxia in children with sensorineural hearing loss combined liver disease

Is Fetal Hemoglobin Level A Prognostic Indicator For The Severity Of Sickle Cell Disease.

Genetic and environmental factors are believed to pay a role in the variation in clinical severity of sickle cell disease in different populating group. Among these, fetal Hb expression is one such epistatic factor which may ameliorate severity of the disease as it can reduced the polymerization sickle RBCs. The present work was undertaken to look for correlation between severity of the disease and the expression of HbF. A total of 110 sickle cell disease cases in the age group of 2-49 years were studied. The HbF levels varied from 2-24% with mean of 10.53+ 406%. Our findings did not shown any statistically significant correlation between HbF levels and clinical severity. Nevertheless the mean HbF levels were slightly higher in the group of patients not having any history of painful crisis, infections, need for hospitalisation or blood transfusions. Further the levels of HbS were significantly lower when the HbF levels were high (>10%). This suggests that variation in clinical severity in sickle cell disease may be more due to role of other genetic factors like associated alpha thalassaemia and the higher HbF may only offer an added advantage to these patients.

Amino acid sequence of the fetal chain of yak haemoglobin.

The amino acid sequence of the fetal chain of yak haemoglobin was determined. The sequence is the same as that of the fetal chain of bovine haemoglobin. Phenylalanine is present at position 12 of the helix A in the fetal chain while tryptophan is the amino acid at this position in the β-chain of yak adult haemoglobin. This amino acid replacement may be responsible for the higher oxygen affinity of yak fetal haemoglobin than yak adult haemoglobin.