Predictive Value of Plasma Fibrin Monomer Level on Postoperative Venous Thromboembolism in Fracture of Lower Limb / 现代检验医学杂志

Objective To investigate the predictive value of plasma fibrin monomer (FM) level on postoperative venous thromboembolism (VTE) in fracture of lower limb.Methods Retrospectively analyzed the clinical data of 126 patients underwent internal fixation of lower limb fracture from January to December 2016,including perioperative plasma prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (Fib),D-dimer (DD) and FM.And all patients were divided into VTE group (n=19) and non-VTE group (n=107) according to the venous color Doppler ultrasonography of lower limb and follow up result.The change of coagulation and fibrinolysis indexes were compared before and after operation,and the area under the receiver operating characteristic curve (AUC) was performed to evaluate these indicators' predictive value for postoperative VTE.Results ①APTT,Fib,DD and FM increased significantly after operation in all patients (F=3.550 ～ 9.223,all P＜ 0.05).Among them,FM increased significantly at 1 d after operation,then gradually decreased.②There were no significant differences in APTT,Fib,DD and FM before operation between two groups (F=0.652～1.120,all P＞0.05).Compared with non-VTE group,FM at 1,3 and 5d after operation increased significantly (t=2.548～ 2.883,all P＜0.05),in which the difference of each index were largest at 3d after operation.③In four indexes including APTT,Fib,DD and FM at 3d after operation,the AUC and Youden index of FM were largest [0.713 (95％ CI.0.620 ～ 0.823) and 0.399].Conclusion There were coagulation and fibrinolysis system activated in fracture of lower limb after operation.Plasma FM at 3d after operation had high predictive value of postoperative VTE,and its effect was better than DD.

The Significance of fibrin monomer,D-Dimer and other blood coagulation indicators detection in the early diagnosis of DIC in obstetrics / 国际检验医学杂志

Objective To investigate the significance of fibrin monomer(FM ) ,D‐Dimer(D‐D) and other blood coagulation indica‐tors detection in the early diagnosis of disseminated intravascular coagulation(DIC) in obstetrics .Methods 90 healthy women with‐out pregnancy(control group) ,270 normal pregnant women including early ,mid‐,late pregnancy(90 cases for each) ,36 early DIC puerperas(early DIC group) were enrolled in the study .FM ,D‐D ,prothrombin time (PT ) ,activated partial coagulation activity (APTT) ,fibrinogen(FIB) levels were detected for those people .Results The levels of D‐D and FM in early DIC group were signif‐icantly higher than those in control group (P<0 .05) ,and PT ,APTT in late pregnant group were significantly shorter than those in early ,mid‐pregnant group and control group ,while FIB was significantly higher ,the difference was statistically significant(P<0 .05) .Conclusion PT ,APTT and FIB can reflect the high blood coagulation state in the late pregnancy ,but can not be used in the diagnosis of early DIC .D‐D and FM have important value for the early diagnosis of DIC in obstetrics .

Determination of plasma fibrin monomer and Dˉdimer in gerontal patients with malignant tumor and its clinical significance / 国际检验医学杂志

Objective To explore the diagnosis and clinical application of fibrin monomer(FM)and D-dimer(D-D)in gerontal pa-tients with malignancy tumor.Methods FM and D-D were detected in 29 gerontal patients with malignant tumor,20 gerontal pa-tients with non-malignant tumor,24 gerontal healthy controls and 30 non-gerontal healthy controls by immunoturbidimetry(ITM). Results The testing results of FM and D-D in the tumor patients were significantly higher than those in the healthy controls(P 0.05).There was no statistical difference in FM between the gerontal healthy examination and non-gerontal healthy examination(P >0.05).There was statistical difference in D-D between the gerontal healthy examination and non-gerontal healthy examination (P < 0.05 ).Conclusion FM and D-D could be used as the indicators for diagnosing tumor thrombus in gerontal patients with tumor.However,D-D has meaningless in diagnosing tumor thrombus.In the diagnosis of tumor thrombus in gerontal patients with malignant tumor,the combination of FM and D-D should be needed.

Evaluation of the Diagnostic Performance of Fibrin Monomer in Disseminated Intravascular Coagulation / 대한진단검사의학회지

BACKGROUND: Fibrin-related markers (FRM) such as fibrin monomer (FM) and D-dimer (DD) are considered useful biological markers for the diagnosis of disseminated intravascular coagulation (DIC). However, no studies on the diagnostic performance of different FRMs have been published in Korea. The aim of this study was to evaluate the diagnostic performance of FM for DIC in comparison with DD. METHODS: The reference limit of FM was determined based on plasma sample data obtained from 210 control individuals. To evaluate diagnostic performance, FM data from the plasma samples of 139 patients with DIC-associated diseases were obtained for DIC scoring. FM was measured by immunoturbidimetry using STA-LIATEST FM (Diagnostica Stago, France). Patients were classified according to the DIC score as non-DIC, non-overt DIC, or overt DIC. ROC curve analyses were performed. RESULTS: The reference limit in the control individuals was determined to be 7.80 microg/mL. Patients with DIC-associated diseases were categorized as non-DIC (N=43), non-overt DIC (N=80), and overt DIC (N=16). ROC curve analyses showed that the diagnostic performance of FM was comparable to DD in both non-overt DIC and overt DIC (P=0.596 and 0.553, respectively). In addition, FM had higher sensitivity, specificity, positive predictive value, and negative predictive value than DD for differentiating overt DIC from non-DIC. CONCLUSIONS: This study demonstrated that the diagnostic performance of FM for DIC was comparable to DD. FM might be more sensitive and more specific than DD in the diagnosis of overt DIC, but not non-overt DIC.

Evaluation of the Diagnostic Performance of Fibrin Monomer in Disseminated Intravascular Coagulation / 대한진단검사의학회지

BACKGROUND: Fibrin-related markers (FRM) such as fibrin monomer (FM) and D-dimer (DD) are considered useful biological markers for the diagnosis of disseminated intravascular coagulation (DIC). However, no studies on the diagnostic performance of different FRMs have been published in Korea. The aim of this study was to evaluate the diagnostic performance of FM for DIC in comparison with DD. METHODS: The reference limit of FM was determined based on plasma sample data obtained from 210 control individuals. To evaluate diagnostic performance, FM data from the plasma samples of 139 patients with DIC-associated diseases were obtained for DIC scoring. FM was measured by immunoturbidimetry using STA-LIATEST FM (Diagnostica Stago, France). Patients were classified according to the DIC score as non-DIC, non-overt DIC, or overt DIC. ROC curve analyses were performed. RESULTS: The reference limit in the control individuals was determined to be 7.80 microg/mL. Patients with DIC-associated diseases were categorized as non-DIC (N=43), non-overt DIC (N=80), and overt DIC (N=16). ROC curve analyses showed that the diagnostic performance of FM was comparable to DD in both non-overt DIC and overt DIC (P=0.596 and 0.553, respectively). In addition, FM had higher sensitivity, specificity, positive predictive value, and negative predictive value than DD for differentiating overt DIC from non-DIC. CONCLUSIONS: This study demonstrated that the diagnostic performance of FM for DIC was comparable to DD. FM might be more sensitive and more specific than DD in the diagnosis of overt DIC, but not non-overt DIC.