The effect and their mechanisms of gastric mucosal protective drugs / 中华消化杂志

Objective To compare the protective effect of colloidal bismuth subcitrate-1 (CBS-1, Lizudele), or colloidal bismuth subcitrate-2 (CBS-2, De-Nol) and sucralfate against gastric mucosal lesion and to investigate their mechanisms. Methods Gastric mucosal injury of rats was induced by ethanol, stress, aspirin and hydrochloric acid. Gastric ulcer was then induced by 50% acetic acid applied to the gastric tunica serosa. We observed the protective effects against gastric mucosal lesion and measured the injury index and the area of ulcer in each group. Statistical t test was used to compare the difference of each group. Results (1)CBS-1, CBS-2, and sucralfate had protective effect against lesions caused by ethanol, stress, aspirin and hydrochloric acid and could promote acetic acid-induced gastric ulcer healing. (2) The mechanisms of protective effect and ulcer healing promotion were that these drugs could increase gastric blood flow and increase activities of QR, GST and GR, and could also promote overexpression of bFGF mRNA and iNOS mRNA. Conclusion Gastric mucosal protective drugs, CBS and sucralfate had effect of resisting injury and promoting ulcer healing. The mechanisms were that they could increase gastric mucosal blood flow and the expression of bFGF mRNA and iNOS mRNA, and reduce oxygen free radical.

Effects of Moxibustion on the Gastric Blood Flow in Rabbits. Effects of Moxibustion Stimulation of the Crus (S 36 "zusanli") / 全日本鍼灸学会雑誌

To determine the effect of moxibustion on blood flow in the gastric wall, gastric blood flow was measured seven times by H² clearance method at 30 minute intervals in 14 anesthetized female rabbits. Moxibustion stimulation was performed 3 times at one acupuncture point on the left hindleg (S 36 zusanli) just before the third measurement.<br>The level of gastric blood flow was high during the initial measurement after induction of anesthesia, and then gradually decreased in both groups. In the control group (without moxibustion: n=6) the blood flow showed a continuous decrease, but in the stimulation group (n=8) it tended to increase momentarily by about 1.5ml·min^-1·100g^-1 at the third measurement (just after moxibustion) and 2.0ml·min^-1·100g^-1 at the fourth measurement, amounting to 22.7±2.4ml·min^-1·100g^-1 at the third measurement (control group: 18.9±1.9) and 23.2±2.9ml·min^-1·100g^-1 at the fourth measurement (control group: 18.0±2.2). The increase in the blood flow was observed in 5 of 8 cases in the stimulation group. However, there was no increase observed in the control group. The increased blood flow in the stimulation group began to gradually decrease, but the values remained higher than the values in the control group until the last measurement. Significant difference, p<0.05, was found between the changes in the blood flow in the two groups.<br>Since the increment of the blood flow after moxibustion was supposed to be due to the vasodilation, it is suggested that moxibustion may cause the dilation of the gastric blood vessels owing to excitation of the vagal nerve and/or inhibition of the splanchnic nerve.