In Silico Screening Of Zinc Database For Discovery Of Novel Urease Inhibitors As A Remedy To Gastro-Duodenal Ulcer Caused By Helicobacter Pylori

Design and synthesis of novel urease inhibitors taking center stage now days with specific attention as a remedy to Helicobacter pylori infection. A number of inhibitors fail in vivo and in clinical trial owing to the toxicity and hydrolytic profile. In the present study, we are making an attempt to screen a large small molecule database, ZINC, for a potential urease inhibitor. The structure based drug discovery approach has been adopted with acceptable ADMET parameters so that the lead molecules may have fair chances of passing in vitro and in vivo trails. The lead molecule in our study, with ID ZINC90446454 is a urea derivative and predicted to be nontoxic. It comes out to be a promising drug candidate with pKd value 7.83, LE 0.429 and LD50 value 10100 mg/kg body weight. Its sulfanyl derivative, with predicted high LD50 (10100 mg/kg body weight), exhibits the feasibility of a disulfide covalent bond with Cys321 in the active site. The derivative may serve as a novel covalent inhibitor with high specificity, high potency and low toxicity. The derivative, in future, may be a successful drug candidate for H. pylori induced gastro-duodenal ulcer.

Evaluation on the therapeutic effects of Che day in the treatment for gastro-duodenal ulcer in clinical, endoscopy and pathological anatomy

Background: Che day is a commonly used traditional medicine among the mountainous ethnic people to treat gastro-duodenal ulcer. Its scientific name is Ampelopsis Cantoniensis Planch (Vitaceae). It is known that chemical components of che day includes flavonoid, tanin and uronic compound, which is able to relieve pain completely. Objectives: Evaluation of analgesic, cicatrisation, anti-inflammation and Helicobacter Pylori (HP) eradicating effects of che day in the treatment of gastro-duodenal ulcer and also investigate the side effects of che day. Subject and methods: 80 patients with gastro-duodenal ulcers were seen with endoscopy, suffering from epigastric pain. The study was carried out in the way of a double - blind method, comparing the results between the group che day and the Alusi cotrolled group. Results: On average, the time when the pain receded is 8.9 days in the che day group, faster than the Alusi controlled group (17.35 days, p < 0.01). The rate of the cicatrisation by che day is 79.55%, higher than the Alusi (47.22%; p < 0.001). In pathological anatomy, the rate of HP eradicating of che day is 42.5%, higher than the Alusi (19.35%, p < 0.01); the rate of recovery from gastritis of che day is 23.25%, higher than the Alusi (9.09%, p < 0.01) and the rate of total recovery of che day is 44.19%, higher than the Alusi; (27.27%, p < 0.01), Conclusions: The che day is effective in relieving gastro-duodenal ulcer \u2013 induced pain for the average of 9 days. In endoscopy, the rate of cicatrisation of che day is 79.55%, in which, good cicatrisation is 54.28%. In pathological anatomy, the che day is effective in eridicating HP with the rate of 42.5 %; The rate of recovery is 23.25% and che day has no side effects.

Decrease in prevalence of peptic ulcer and gastric adenocarcinoma at the Policlínico Peruano Japonés, Lima, Peru, between the years 1985 and 2002. Analysis of 31,446 patients / Disminución de la prevalencia de la úlcera péptica y el adenocarcinoma gástrico en el policlínico Peruano-Japonés, Lima, Perú

Aim: To determine the prevalence of peptic ulcer and gastric adenocarcinoma in a population of middle and high socio-economic status in Lima, Peru, between 1985 and 2002. Materials and methods: The prevalence of gastroduodenal ulcer and gastric adenocarcinoma was determined after studying by esophagogastroduodenoscopy 31,446 patients at the Policlínico Peruano Japonés (PPJ) between 1985 and 2002. All patients had chronic upper gastrointestinal symptoms and had endoscopically proven diagnosis of active peptic ulcer or histological diagnosis of gastric adenocarcinoma. Results: Analysis of PPJ population identified a decrease in the prevalence of gastric ulcer and duodenal ulcer from 3.15% and 5.05% respectively in 1985, to 1.62% and 2.00% respectively in 2002. Gastric adenocarcinoma prevalence also decreased from 3.19% in 1988 to 0.92% in 2002. The prevalences of gastric ulcer (OR=1.49, 95% IC 1.26-1.77, p<0.001), duodenal ulcer (OR=1.32, 95% IC 1.15- 1.51, p<0.001) and gastric adenocarcinoma (OR=1.53, 95% IC 1.25-1.86, p<0.001), decreased in the last eight years. Conclusions: Over the study period, there was a significant decrease in the prevalence of peptic ulcer and gastric adenocarcinoma at the PoliclínicoPeruano Japonés, where patients from middle and high socio economic status are attended.

Objetivo: Determinar la prevalencia de la úlcera péptica y el adenocarcinoma gástrico, en una población de nivel socioeconómico medio y alto en Lima, Perú, entre los años 1985 y 2002. Material y métodos: Se determinó la prevalencia de la úlcera gastroduodenal y el adenocarcinoma gástrico, después de evaluar por esofagogastroduodenoscopía 31,446 pacientes en el Policlínico Peruano Japonés (PPJ) entre 1985 y 2002. Todos los pacientes presentaron síntomas crónicos del tracto gastrointestinal superior, y en ellos se realizó el diagnóstico endoscópico de úlcera péptica activa e histológico de adenocarcinoma gástrico. Resultados: Luego del análisis de la población estudiada se identificó una disminución de la prevalencia de úlcera gástrica y úlcera duodenal de 3,15% y 5,05% respectivamente en 1985, a 1.62% y 2.00% respectivamente en el año 2002. La prevalencia de adenocarcinoma gástrico también disminuyó de 3,19% en 1992 a 0,92% en el año 2002. Las prevalencias de ulcera gástrica (OR =1.49, 95% IC 1.26-1.77, p<0.001), úlcera duodenal (OR =1.32, 95% IC 1.15-1.51, p<0.001) y adenocarcinoma gástrico (OR =1.53, 95% IC 1.25-1.86, p<0.001), disminuyeron en los últimos 8 años cuando comparamos con los primeros años. Conclusiones: Durante este período de estudio se observó una significativa disminución de la prevalencia de la úlcera péptica y el adenocarcinoma gástrico en pacientes peruanos de nivel socio económico medio y alto que son atendidos en este nosocomio.

Resistance and electrointensity characteristics of couples Yuan points in patients with gastro-duodenal ulcer

120 subjects were selected and divided into two groups to study resistance and intensity of 12 couples of Yuan point. Case group involved 60 subjects aged>50, suffered from duodenal ulcer (30 males, 30 females). Control group involved 60 subjects aged>50 (30 males, 30 females) without this condition. The results showed that: there were difference in resistance and intensity of Tai chong point (Iiv3) of the left and right body in both male and female (p<0.05-0.01), but not in the other ones. Resistance of 12 couples of Yuan point of duodenal-ulcer group was markedly higther whereas intensity was lower in comparing with control group, especially in Da ling TH7, Chong yang St42, Tai bai Sp3. Hegu Ll4. Yang chi HC4.

Assessment of pH of gastric juice in patients with gastro-duodenal erosion or ulcer at Bac Giang General Hospital

This is a study to build up a technical procedure for taking gastric juice via gastroscope and measuring pH on 438 patients with gastro-duodenal erosion or ulcer at Bac Giang General Hospital. Results: the technique of taking gastric juice by leading the tip of gastroscope in the “liquid puddle” and then sucking gastric juice through biopsy canal by a syringe of 100ml had been 94.6% successful; this technique is simple and easy to do. Measuring pH of gastric juice on 363 patients with gastro-duodenal erosion or ulcer found no patient with pH<1; over 80% of them were found with gastric juice pH 1 to 3; pH of gastric juice has no relation with age and sex

Problem on the treatment of gastro duodenal ulcer

There are two main causes associate with the gastro ulcer and duodenal ulcer, H. pylori is a greatest cause with 95% and 85%, respectively. The treatment regime invoved use of antibiotics combined with acid secretion inhibitors. In addition, secondly cause due to using non steroid anti inflammatory drug, but this cause is remainly dispute, so the treatment of gastro duodenal ulcer have many problems as regime, duration and following time. It should identify to influence of H. pylori on ulcer due to NSAID and role of anti-bacterial vaccination.

Analysis of prescriptions in gastro-duodenal ulcer at a hospital of central level

An evaluation on using drugs that treated for patients with peptic ulcer and gastritis in Gastroentrology Department of a central hospital in Hanoi was established. The results showed that: 87.44% of patients with H.P positive - test were treated by combination of 2 antibiotic and an acid secretion inhibitor. 88.58% patients with H.P negative test were treated by an acid secretion inhibitor. 60.73% and 55.86% of patients with H.P negative - test and H.P positive - test were treated with antacids, respectively. 35.21% of combinations give interaction, mainly caused by the presence of antacids