Genome instability and lymphoma / 中南大学学报(医学版)

Lymphoma is one of the most common malignant tumor of the hematologic system. The genome instability is not only an important molecular basis for the development of lymphoma, but also has important value in the diagnosis and prognosis of lymphoma. There are 2 types of genome instability: Microsatellite instability (MSI/MIN) at gene level and chromosomal instability at chromosome level. Through the study on genes associated with lymphoma, the unstable genes associated with lymphoma could be found, meanwhile the mechanism of its occurrence and development of lymphoma could be explored, and the important basis of molecular biology could also be provided in the field of current hot lymphoma precision medical research.

Genetic instability in Streptomyces.

Genetic instability is very common among Streptomyces strains and the affected strains display several distinctive phenotypes. In several cases DNA rearrangements, specifically deletions and amplifications of specific segments of DNA, were demonstrated. Depending upon the reproducible amplification of a segment in independent isolates one could predict the basic structural elements involved in the amplification process. In the case of S. lividans 66, 5·7 kb amplifiable DNA sequence is located near the end of the linear chromosome. Amplification of this sequence and deletion of the chromosome linked to it leads to the creation of a new end or in some cases even circularisation of the chromosome occurs. A model incorporating these aspects is discussed. The possible involvement of proteins encoded by the amplifiable region is also discussed.