RESUMO
@#Herpes simplex viral keratitis(HSK)is caused by herpes simplex virus a serious infective corneal disease. Herpes simplex virus(HSV)infection comes in two forms: primary and recurrent.Between them, the recurrent herpes simplex virus infection way of relevant mechanisms and intervention is the research focus in recent years. In this article, we've introduced the recurrent immune system and treatment of the recurrent herpes of herpes simplex, analysed the newly discovered drugs against herpes simplex virus recurrence, and we're hoping to develop a new form of intervention, a chemical that has a stronger effect and less toxic, so that we can reduce the potential side effects and provide better treatment results.
RESUMO
To assess the efficiency and reliability safety of ganciclovir to herpes simplex virus keratitis. ●METHODS: All of the randomized controlled trials for the study of ganciclovir versus acyclovir in the treatment of herpes simplex virus keratitis were collected from Cochrane Library, EMbase, PubMed, Chinese Bio -medicine Database, China Journal Full-text Database, VlP Database and WanFang Database. Then the data were extracted and evaluated by two reviewers independently. Risk of bias assessment was evaluated by a tool recommended by Cochrane Library. Revman 5. 0 software was used for statistical analysis. ●RESULTS: Finally, 14 randomized controlled trials were included, 4820 patients totally. Subgroups were used according to the number of patients and diseased eyes as well as the difference of follow-up time. For and relapse rate, ganciclovir group was overmatch acyclovir group. There were statistical differences between the two groups [RR= 1. 22, 95%CI (1. 10-1. 36); OR = 4. 50, 95% CI (2. 02-10. 04); RR = 0. 23, 95% CI (0. 10-0. 52)]. Compared with acyclovir, ganciclovir had less side - effect. There were statistical differences between the two groups [RR = 0. 12, 95%CI (0. 03 - 0. 46)]. All of the side effects of the two groups can be relieved by themselves. ● CONCLUSlON: Current evidence suggests that the ganciclovir is more efficient and safe than acyclovir in the treatment of herpes simplex virus keratitis.