Influence of Removing Dampness,Melting Phlegm and Tonifying Spleen Method on Nitric Oxide Synthase and Gene Expression of Vascular Endothelial in Hyperlipidemia Rats / 中国中医药信息杂志

Objective To observe the law of removing dampness, melting phlegm and tonifying spleen on blood lipids in hyperlipidemia rat and its vascular endothelial protective effect. Methods Animals were randomly divided into 6 groups, the high-fat diet of 35 d, 16 d orbital check blood lipids to confirm modeling success and gavage was given by different experimental requirements. NOS and vascular endothelial gene expression were determined at 3rd and 7th day. Results After treatment, NOS expression in experimental rats compared with the normal group, P

Effect of Ganoderma lucidum on cholesterol drunk-induced hyperlipidemia rats

Objectives: To evaluate the influence of Ganoderma lucidum on cholesterol drunk - induced hyperlipidemia rats. Methods: Rats were received cholesterol in the oral daily during 8 consecutive weeks in order to hyperlipidemia rats. From 5th week, extract of Ganoderma lucidum (GL) at the doses of 2g/kg, 4g/kg administered orally was investigated in cholesterol drunk - induced hyperlipidemia rats. Results: GL significantly decreased plasma triglycerid, total cholesterol, LDL - C, but increased HDL - C. The effect of GL on plasma lipid level at the oral doses of 2g/kg, 4g/kg was equal to each other and to Lopid (gemfibrozil) at the dose of 140mg/kg. Conclusions: GL have a hypolipidemia effect on rats.