Regulation of the Sigma-1 Receptor on Chronic Pain and Its Neuromechanism / 中国生物化学与分子生物学报

Sigma-1 receptor (Sig-1R) is a ligand-regulated chaperone protein widely expressed in multiple regions of the nervous system. It mediates intracellular effects of several types of ion channels and G protein coupled receptors (GPCRs) by binding them, and regulates intracellular Ca

Research progress on the role and mechanism of Wnt signaling pathway in neuropathic pain / 药学学报

Neuropathic pain (NP), as a kind of chronic pain syndrome, seriously endangers the quality of life of patients, and the pathogenesis is complex, clinical treatment is limited, and it is easy to relapse. More and more reports have found that Wnt signaling pathway is closely related to the occurrence and development of neuropathic pain. Therefore, further study of the Wnt signaling pathway may provide useful ideas for exploring the pathogenesis of NP and discovering effective treatment methods. This article reviews the role and mechanism of Wnt signaling pathway in neuropathic pain.

Prevention of hydromorphone on postoperative hyperpathia in patients receiving remifentanil combined anesthesia / 中国基层医药

Objective@#To explore the clinical effect of hydromorphone in the prevention of postoperative hyperpathia in patients receiving remifentanil combined anesthesia.@*Methods@#64 patients who were scheduled to receive abdominal surgery and postoperative analgesia were randomly divided into hydromorphone group(n=32) and control group (n=32) according to random number table.All the cases were given PCIA after surgery, the control group was given fentanyl 12.5μg/kg, and the hydromorphone group was given fentanyl 12.5μg/kg + hydromorphone 10μg/kg.The postoperative analgesic effects at different time, postoperative recovery, usage of PCIA and incidence of adverse effects in two groups were compared.@*Results@#There were no statistically significant differences in respiration recovery time, wake-up time, extubation time between the two groups (t=1.21, 0.83, 0.33, all P>0.05). The levels of MAP, HR after extubation of the hydromorphone group were significantly lower than those of the control group (t=2.84, 2.66, all P<0.05). The VAS scores at 30 min, 1h, 2h, 4h, 12h after operation in the hydromorphone group were significantly lower than those in the control group (t=8.83, 5.25, 8.77, 9.51, 9.69, all P<0.05), while the difference was not statistically significant between the two groups at 24h after operation (t=1.87, P>0.05). The press times and dosage of fentanyl during 1h, 24h after surgery of the hydromorphone group were significantly less than those of the control group(t=16.71, 36.38, 43.05, 10.98, all P<0.05). The adverse reactions between the two groups had no statistically statistical difference (χ2=0.14, P>0.05).@*Conclusion@#Postoperative analgesia of remifentanil combined anesthesia with hydromorphone can effectively prevent RIH, reduce other anesthetics dose, and does not increase the risk of complications.

Dorsal Root Entry Zone Lesions for Intractable Pain Control

It is well documented that dorsal root entry zone(DREZ) lesions were good method to control intractable chronic deafferentation pain of spinal origin which was not controlled with various medical and surgical treatment. Experience with radiofrequency lesions of dorsal root entry zone in 3 of patients with post herpetic pain and 1 of patient with post amputation pain are reported. The follow-up period ranging from 3-20 months and all patients obtained satisfactory pain relief.