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Objective To summarize the clinical and MSCT manifestations of infectious lesions around the ileocecus.Methods The clinical and CT manifestations of 147 patients with infectious lesions around the ileocecus were analyzed retrospectively.All of patients were confirmed by postoperative pathology or clinical diagnosis.Results Of 147 patients,there were 119 cases of appendicitis, including 2 cases of ileocecal tumor combined with acute appendicitis;1 1 cases of colonic diverticulitis,including 5 cases with bezoars in diverticulum (perforation occurred in 3 cases);14 cases of abdominal abscess (9 cases showed peripheral slightly hyper-density and central hypo-density masses,and 5 cases showed the faveolate inhomogeneous hypo-density,significantly enhanced walls and septum on enhanced CT imaging);3 cases of right tubal abscess showing sausage-like hypo-density.Conclusion CT shows high sensitivity and specificity for the diagnosis of infectious lesions around the ileocecus.MSCT manifestations are more overlapped among different infectious lesions around the ileocecal region,and clinical features of these diseases are similar,which can cause missed diagnosis and misdiagnosis.
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[Objective] To observe the dynamic changes of intestinal IL-17,occludin,and ZO-1 in mice with postinfectious irritable bowel syndrome (PI-IBS).[Methods] Forty C57BL/6 mice were randomly divided into 5 groups:control group and infection groups (2 weeks,4 weeks,6 weeks,and 8 weeks after trichinella infection).Infection groups were given by gavaging of 400～500 Trichinella spiralis in 0.2 mL of normal saline.The body weight of mice were recorded at week 2,4,6,and 8 after infection.The visceral sensitivity of mice was measured by the abdominal withdrawal reflex (AWR).The stool was collected continuously for 8 hours to calculate the percentage of fecal water content.Pathological changes of gut were observed by HE staining.The expressions of IL-17,occludin,and ZO-1 in ileocecus and colon were detected by immunohistochemistry and Western blotting.[Results] At week 2 after infection,the acute inflammation of the intestinal tract was observed and the body weight of mice were significantly decreased (P=0.000).Until week 8 after infection,the intestinal inflammation and body weight of mice recovered to normal.When the colorectal dilatation capacity was 0.35 and 0.5 mL,the AWR scores in the infection groups were significantly higher than those in the control group (P＜0.01).The percentages of fecal water content in the infection groups were significantly higher than those in the control group (P＜0.05).Compared with the control group,the expressions of IL-17 were significantly decreased in week 2 group (P＜0.05) and increased in week 8 group (P＜0.05).The expressions of occludin and ZO-1 in the infection groups were significantly lower than those in the control group (P＜0.05).[Conclusion] The dynamic changes of IL-17 and the decrease of Tight junction proteins may be one of the mechanisms of visceral hypersensitivity and increased percentages of fecal water content.They may be involved in the development of PI-IBS.