Feedback received and role performance: The mediating role of engagement and the moderating role of authentic living

This research aims to identify the moderating role of authentic living in the relationship between feedback received and role performance, mediated by work engagement. The data were based on a convenience sample of Brazilian workers from public and private organizations (N = 1,244). The significant interaction between the feedback and authentic living allowed us to understand that the main effects of feedback on performance take place in individuals with high authentic living. When individuals are more authentic, the information they receive about their performance more strongly affects the motivational process at work itself. This study highlights the positive relationship between work and personal resources, as well as the work engagement and performance on the other, thus contributing to increase the feedback the organizations receive about performance, as well as to create environments that facilitate authenticity.

O objetivo desta pesquisa foi identificar o papel moderador da vivência autêntica na relação do feedback recebido com o desempenho de papéis, mediado pelo engajamento no trabalho. Os dados foram obtidos a partir de uma amostra por conveniência de trabalhadores brasileiros provenientes de organizações públicas e privadas (N = 1.244). A interação significativa entre o feedback e a vivência autêntica permitiu compreender que os maiores efeitos do feedback sobre o desempenho acontecem em indivíduos com elevada vivência autêntica. Quando os indivíduos são mais autênticos, as informações que os mesmos recebem sobre o desempenho afetará mais fortemente o próprio processo motivacional no trabalho. Este estudo fornece evidências da relação positiva entre os recursos do trabalho e pessoais com o engajamento e o desempenho no trabalho, contribuindo, assim, para um aumento, por parte das organizações, do feedback recebido sobre o desempenho, bem como a criação de ambientes facilitadores de autenticidade.

El objetivo de esta investigación fue identificar el papel moderador de la experiencia auténtica en la relación entre la retroalimentación recibida y el desempeño de roles, mediada por el compromiso laboral. Los datos se obtuvieron de una muestra por conveniencia de trabajadores brasileños de organizaciones públicas y privadas (N = 1244). La interacción significativa entre la retroalimentación y la experiencia auténtica permitió comprender que los mayores efectos de la retroalimentación sobre el desempeño ocurren en individuos con alta experiencia auténtica. Cuando los individuos son más auténticos, la información que reciben sobre el desempeño afectará más fuertemente su propio proceso motivacional en el trabajo. Este estudio proporciona evidencia de la relación positiva entre el trabajo y los recursos personales con el compromiso y el desempeño en el trabajo, de esta forma contribuyen al aumento, por parte de las organizaciones, de la retroalimentación recibida sobre el desempeño, así como a la creación de entornos propicios de autenticidad.

Covid-19: fatores associados ao uso adequado de equipamentos de proteção individual por trabalhadores da atenção primária / Covid-19: factors associated with the use of personal protective equipment by primary care workers

O estudo tem como objetivo analisar os fatores associados ao uso adequado dos Equipamentos de Proteção Individual (EPI) pelos trabalhadores da Atenção Primária à Saúde (APS). Estudo transversal, realizado no Brasil, em ambiente virtual entre os meses de agosto/2020 e março/2021. Para a coleta de dados utilizou-se o instrumento validado "E.P.I. - APS COVID-19". Foram utilizados testes qui-quadrado ou exato de Fisher, razão de prevalência, Intervalo de Confiança de 95% e regressão de Poisson com significância p≤0,005. Pesquisa aprovada pelo Comitê de Ética em Pesquisa com Seres Humanos. Participaram da pesquisa 455 trabalhadores. Os trabalhadores com 37 anos ou mais apresentaram prevalência de 1,59 vezes maior para uso adequado de óculos/protetor facial, 1,39 vezes maior para máscara N95 e 1,23 vezes maior para a higienização correta das mãos. O uso de luvas apresentou uma prevalência 35% maior para os trabalhadores com carga horária ≤ 40 horas. A faixa etária 37 anos ou mais foi associada ao uso de máscara N95 (RP=1,107) e a higiene das mãos (RP=1,075). A carga horária ≤ 40 horas foi associada ao uso de luvas (RP=0,846). Conclui-se que são fatores associados ao uso adequado de EPI a faixa etária 37 anos ou mais e a carga horária ≤ 40 horas.

This study aims to analyze the factors associated with the proper use of Personal Protective Equipment (PPE) by Primary Health Care (PHC) workers. Cross-sectional study, carried out in Brazil, in a virtual environment between August/2020 and March/2021. For data collection, the validated instrument "P.P.E. - PHC COVID-19" was used. Chi-square or Fisher's exact tests, prevalence ratio, 95% confidence interval, and Poisson regression with p≤0.005 significance were used. The research was approved by the Ethics Committee for Research with Human Beings and 455 workers participated in the survey. Workers aged 37 years or older had a prevalence of 1.59 times higher for proper use of glasses/face shields, 1.39 times higher for N95 masks, and 1.23 times higher for correct hand hygiene. The use of gloves showed a 35% higher prevalence for workers with working hours of ≤ 40 hours. The age group 37 years or older was associated with the use of N95 masks (PR=1.107) and hand hygiene (PR=1.075). Working hours of ≤ 40 hours were associated with the use of gloves (PR=0.846). It is concluded that the factors associated with the proper use of PPE are age group 37 years or older and working hours of ≤ 40 hours.

Efeitos da dupla proteção auditiva na saúde do trabalhador: revisão de literatura / Effects of double hearing protection on occupational health: a literature review / Efectos de la doble protección auditiva en la salud de los trabajadores: revisión de la literatura

O uso da proteção auditiva pode representar uma série de preocupações de segurança quando considerados o treinamento e orientação, os prejuízos à comunicação e o ambiente ocupacional. O objetivo deste estudo foi verificar os benefícios da dupla proteção auditiva em risco de ruído ocupacional. Os artigos científicos de embasamento foram selecionados pelas bases de dados MEDLINE (Pubmed), Lilacs, Scielo, SCOPUS e Web of Science, sem restrição de idioma, período e localização. Foram localizados 197 artigos em que três atenderam aos critérios de admissão desta pesquisa. Os Equipamentos de Proteção Individual (EPIs) exigem controle rigoroso quanto ao seu uso adequado, que por vezes é negligenciado na rotina diária de trabalho. Conclui-se que a modernização e o uso de tecnologias mais seguras tem o intuito de diminuir o impacto da exposição ao ruído, entretanto, as barreiras entre a economia e a adesão pelos trabalhadores ainda precisam ser minimizadas.

Use of hearing protection can raise a series of safety concerns when considering training and guidance, communication impairments, and occupational environment. Hence, this study assessed the benefits of dual hearing protection in occupational noise risk. Scientific articles were selected from the MEDLINE (PubMed), LILACS, SCIELO, SCOPUS, and Web of Science databases, with no language, period, or location restrictions. A total of 197 articles were located, of which three met the inclusion criteria. Proper PPE (Personal Protective Equipment) usage requires strict monitoring, which is sometimes overlooked in the daily work routine. Modernization and use of safer technologies aim to reduce the impact of noise exposure; however, the barriers between the economy and worker adherence still need to be mitigated.

El uso de protección auditiva puede implicar una serie de preocupaciones de seguridad al considerar el entrenamiento y orientación, el daño a la comunicación y el ambiente laboral. El objetivo de este estudio fue determinar los beneficios de la doble protección auditiva en riesgo de ruido laboral. Se seleccionaron los artículos científicos de las bases de datos MEDLINE (PubMed), LILACS, SciELO, Scopus y Web of Science, sin restricciones de idioma, período y ubicación. Se encontraron 197 artículos, de los cuales tres cumplieron con los criterios de inclusión para este estudio. Los equipos de protección individual (EPI) requieren un riguroso control sobre su adecuado uso y, muchas veces, no son utilizados por los trabajadores durante su rutina laboral. Se concluye que la modernización y el uso de tecnologías más seguras pueden reducir el impacto de la exposición al ruido, sin embargo, las barreras entre la economía y el uso de estos equipos por los trabajadores aún necesitan mitigarse.

Determinants of human immuno-deficiency virus pre-exposure prophylaxis uptake and retention among sex workers in Nakuru town Kenya

Background: The purpose of this study was to assess factors associated with human immunodeficiency virus (HIV) pre-exposure prophylaxis uptake and retention among sex workers in Nakuru town, Kenya. The theory of planned behavior and the acquired immunodeficiency syndrome (AIDS) risk reduction model served as the study's theoretical framework. Methods: A cross-sectional research design was adopted for this study. The study targeted all the sex workers in Nakuru town who were 18 years old and above. A random sampling technique was used to get the hotspots where the sex workers were to be found. Snow balling sampling technique was then adopted to identify and recruit the study participants. Using primary sources. The quantitative data was obtained from the respondents using a questionnaire. Quantitative data was analyzed using descriptive and inferential statistics (regression analysis). The findings presented in table and graphical formats. Results: The analysis using multiple linear regression indicated that there was a collective significant effect between the awareness, health system factors, socio economic individual factors and use of pre-exposure prophylaxis (PrEP) among sex workers. A further analysis showed that, put together, the four predictor variables explained 35.7% of variation on PrEP uptake and retention. Conclusions: The study concluded that while use and none use PrEP can be explained by the four factors evaluated in this study, there are a lot of other factors that influence utilization of PrEP.

Influence of demographic parameters and dietary habits on the cytome assay biomarkers in lymphocytes and buccal epithelial cells from a group of argentine adolescents / Influencia de parámetros demográficos y hábitos alimentarios sobre biomarcadores del ensayo citoma en linfocitos y células epiteliales bucales de adolescentes argentinos

ABSTRACT The use of the cytome assay in monitoring studies on children has increased in recent years. For this reason, it is necessary to know the role of possible confounding factors that could affect its outcomes. The objective was to evaluate the influence of some demographic variables and diet on the baseline values of the cytome assay biomarkers in lymphocytes and buccal mucosa cells from a group of Argentine adolescents. Following the calculation of the biomarkers, a multivariate regression analysis including confounders was performed. In lymphocytes it was observed that micronuclei (MNi) had a negative association with a moderate consumption of roots and tubers, while the number of nuclear buds (NBUDs) was higher in minors not exposed to second-hand smoke (SHS). Regarding epithelial cells, MNi had a negative relationship with the intake of tropical fruits and red meat; on the contrary, this parameter increased with the moderate ingestion of legumes. In addition, oral NBUDs had a positive association with citrus and red meat consumption, whereas cereals and oil decreased its frequency. Furthermore, an increased number of binucleated cells was observed for adolescents who ate white meat and an increase in pyknotic cells for those exposed to SHS. These results revealed that in adolescents the baseline level of the cytome assay biomarkers, especially of those related to genotoxicity, can be influenced by exogenous variables, for instance, dietary habits. Thus, such factors need to be considered when carrying out biomonitoring studies on child populations.

RESUMEN El uso del ensayo de citoma en estudios de seguimiento en niños se ha incrementado en los últimos años y resulta necesario conocer el papel de posibles factores de confusión que podrían afectar sus resultados. El objetivo fue evaluar la influencia de algunas variables demográficas y de la dieta en los valores basales de los biomarcadores de este ensayo en linfocitos y células de mucosa bucal de un grupo de adolescentes argentinos. Luego del cálculo de los biomarcadores, se realizó un análisis de regresión multivariada incluyendo factores de confusión. En linfocitos se observó que los micronúcleos (MN) se asociaron negativamente con un consumo moderado de raíces y tubérculos, mientras que los brotes nucleares (BrN) aumentaron en los menores no expuestos al humo de segunda mano (HSM). En células epiteliales, los MN tuvieron una relación negativa con el consumo de frutas tropicales y carnes rojas, aunque aumentaron con el consumo moderado de legumbres. Los BrN orales tuvieron una asociación positiva con el consumo de cítricos y carnes rojas, mientras que los cereales y el aceite disminuyeron su frecuencia. Además, se encontró un mayor número de células binucleadas para quienes comieron carne blanca y un aumento de células picnóticas para los expuestos a HSM. Estos resultados revelaron que en los adolescentes el nivel basal de los biomarcadores del ensayo de citoma, especialmente de aquellos relacionados con la genotoxicidad, puede verse influenciado por variables exógenas como los hábitos alimentarios. Por lo tanto, dichos factores deben considerarse al realizar estudios de biomonitoreo en poblaciones infantiles.

Superbugs Unleashed: Is Time Running Out to Stop the Global Infection Crisis?

The global infection crisis poses a significant threat to public health, with the emergence and spread of antibiotic-resistant bacteria or "superbugs" becoming a major concern.The crisis has been fueled by various factors, including the overuse of antibiotics, inadequate infection prevention and control measures,and the lack of investment in research and development of new treatments.Addressing this issue requires a comprehensive approach that involves improving surveillance and monitoring systems, promoting individual responsibility, and investing in research and development.Collaboration between stakeholders, including governments, healthcare providers, researchers, and the public, is crucial in overcoming the challenges posed by the global infection crisis. Despite promising advances in emerging technologies, sustained investment in research and development is necessary to ensure continued progress in addressing the issue.Failure to take action risks a future where superbugs run rampant and existing treatments become ineffective. It is time to act decisively to halt the spread of superbugs and prevent a global health crisis.

Exercise addiction: a comparison between runners, cyclists, swimmers, and triathletes / Dependência ao exercício: uma comparação entre corredores, ciclistas, nadadores e triatletas / dicción al ejercicio: una comparación entre corredores, ciclistas, nadadores y triatletas

The aim of the present study was to evaluate and compare exercise addiction (EA) between runners, cyclists, swimmers, and triathletes. Took part in this study 39 runners, 32 cyclists, 30 swimmers and 38 triathletes. Exercise Dependence Scale (EDS), and the Exercise Addiction Inventory (EAI) was used to evaluate the EA and classified the participants into: at-risk for EA, nondependent-symptomatic, and nondependent-asymptomatic. Most participants were classified as nondependent symptomatic for EA. The EDS total score was significantly lower in the swimmers compared to the cyclists and triathletes and the EAI total score was significantly higher for cyclists compared to runners. Therefore, in both instruments, the majority of participants was nondependent symptomatic for EA (AU).

O objetivo do presente estudo foi avaliar e comparar a dependência ao exercício (DE) entre corredores, ciclistas, nadadores e triatletas. Participaram do estudo 39 corredores, 32 ciclistas, 30 nadadores e 38 triatletas. As escalas Exercise Dependence Scale (EDS) e Exercise Addiction Inventory (EAI) foram usadas para a avaliação da DE e classificaram os participantes em três categorias: em risco de DE, não dependente sintomático e não dependente assintomático. A maioria dos participantes foram classificadas como não dependentes sintomáticos para DE. O escore da EDS foi significativamente menor nos nadadores comparado aos ciclistas e triatletas e o escore total da EAI foi significantemente maior nos ciclistas comparado aos corredores. Portanto, em ambos os instrumentos, a maioria dos participantes foi não dependente sintomático para DE (AU).

El objetivo del presente estudio fue evaluar y comparar la adicción al ejercicio (AE) entre corredores, ciclistas, nadadores y triatletas. Participaron de este estudio 39 corredores, 32 ciclistas, 30 nadadores y 38 triatletas. La Escala de Dependencia al Ejercicio (EDS) y el Inventario de Adicción al Ejercicio (EAI) fueron utilizados para evaluar la AE y clasificaron a los participantes en tres categorías: en riesgo de AE, no dependiente-sintomático y no dependiente-asintomático. La mayoría de los participantes se clasificaron como no dependiente-sintomático para AE. La puntuación EDS fue significativamente menor en nadadores en comparación con ciclistas y triatletas y la puntuación EAI total fue significativamente mayor en ciclistas en comparación con corredores. Por lo tanto, en ambos instrumentos, la mayoría de los participantes eran sintomáticos no dependientes para AE

Exercise addiction: a comparison between runners, cyclists, swimmers, and triathletes / Dependência ao exercício: uma comparação entre corredores, ciclistas, nadadores e triatletas / Adicción al ejercicio: una comparación entre corredores, ciclistas, nadadores y triatletas

The aim of the present study was to evaluate and compare exercise addiction (EA) between runners, cyclists, swimmers, and triathletes. Took part in this study 39 runners, 32 cyclists, 30 swimmers and 38 triathletes. Exercise Dependence Scale (EDS), and the Exercise Addiction Inventory (EAI) was used to evaluate the EA and classified the participants into: at-risk for EA, nondependent-symptomatic, and nondependent-asymptomatic. Most participants were classified as nondependent symptomatic for EA. The EDS total score was significantly lower in the swimmers compared to the cyclists and triathletes and the EAI total score was significantly higher for cyclists compared to runners. Therefore, in both instruments, the majority of participants was nondependent symptomatic for EA.

O objetivo do presente estudo foi avaliar e comparar a dependência ao exercício (DE) entre corredores, ciclistas, nadado-res e triatletas. Participaram do estudo 39 corredores, 32 ciclistas, 30 nadadores e 38 triatletas. As escalas Exercise Dependence Scale (EDS) e Exercise Addiction Inventory (EAI) foram usadas para a ava-liação da DE e classificaram os participantes em três categorias: em risco de DE, não dependente sintomático e não dependente assintomático. A maioria dos participantes foram classificadas como não dependentes sintomáticos para DE. O escore da EDS foi significativamente menor nos nadadores comparado aos ciclistas e triatletas e o escore total da EAI foi significantemente maior nos ciclistas comparado aos corredores. Portanto, em ambos os ins-trumentos, a maioria dos participantes foi não dependente sinto-mático para DE.

El objetivo del presente estudio fue evaluar y comparar la adicción al ejercicio (AE) entre corredores, ciclistas, nadadores y triatletas. Participaron de este estudio 39 corredores, 32 ciclistas, 30 nadadores y 38 triatletas. La Escala de Dependencia al Ejercicio (EDS) y el Inventario de Adicción al Ejercicio (EAI) fueron utilizados para evaluar la AE y clasificaron a los participantes en tres categorías: en riesgo de AE, no dependiente-sintomático y no dependiente-asintomático. La mayoría de los participantes se clasificaron como no dependiente-sintomático para AE. La puntuación EDS fue significativamente menor en nadadores en comparación con ciclistas y triatletas y la puntuación EAI total fue significativamente mayor en ciclistas en comparación con corredores. Por lo tanto, en ambos instrumentos, la mayoría de los participantes eran sintomáticos no dependientes para AE.

Determinants of teenage pregnancies in a rural area of Zambia: a case study of Chipili district, Zambia

Teenage pregnancies are a serious public health issue around the world and Zambia in particular. This is driven by many factors. The general objective of the study was to explore determinants of teenage pregnancy in Chinshinki village, Chipili district. This was a qualitative study, which adopted a phenomenological study design. Data was collected using a focus group discussion with teenage mothers and four key informants. Participants were purposively selected based on the in-depth knowledge and experience of the phenomenon studied. The data collected was analysed using thematic analysis. The study showed that despite being aware of the various methods of contraception, teenagers still have negative attitudes toward their use. Cultural beliefs of not discussing sexual matters at household level have led to teenagers to search for guidance and information from their peers. The study also revealed that the reduced accessibility and awareness on reproductive health information was influenced by the healthcare workers who did not provide this information to the teenagers in their respective communities. The study showed that despite being aware of the various methods of contraception, teenagers are still not willing to fully utilize these methods. This perception stems from misinformation provided by their peers who play an important role regarding teenagers' decisions about engaging in risky sexual behaviour.

Barreras para una alimentación saludable: un análisis cualitativo de las semánticas emergentes en las comunidades escolares de Ciudad Sur

La literatura ha hecho hincapié en la centralidad que cumplen los entornos alimentarios en las elecciones alimentarias y en el estado nutricional de la población. Objetivo: identificar las percepciones de padres, madres y apoderados, profesionales de establecimientos educacionales, funcionarios municipales, y feriantes pertenecientes a la zona sur de Santiago de Chile, respecto a las barreras y limitaciones de la puesta en práctica de una alimentación saludable en el ambiente alimentario escolar. Método: se realizaron seis grupos focales agrupando a 50 actores claves vinculados a los establecimientos educacionales de Ciudad Sur utilizando una muestra no probabilística. Se aplicó un análisis de contenido mediante la técnica de codificación temática buscando relevar los universos semánticos emergentes. Resultados: se identificaron nueve barreras, o semánticas, que caracterizan limitantes a la realización de la alimentación saludable en los entornos escolares desde la perspectiva de los participantes: la familia, kioscos escolares, la salida de los establecimientos escolares, gusto, determinantes socioeconómicos, política pública, falta de conocimiento, publicidad y disponibilidad de productos sin sellos. Conclusiones: las limitaciones asociadas al ambiente alimentario doméstico tienen una representación significativamente alta (47,9%) y contienen un carácter de responsabilización individual en su enunciación. Esta cultura explicativa es opuesta a la evidencia científica y académica respecto al funcionamiento de la conducta alimentaria, y a la centralidad de los ambientes alimentarios respecto a la facilitación u obstaculización del consumo de alimentos saludables o adecuados.

Literature has emphasized on food environments centrality in food choices and nutritional status. Objective: identify social perceptions of fathers, mothers and guardians, professionals from educational establishments, municipal officials, and stallholders belonging to the southern area of Santiago de Chile, regarding limitations of healthy diet implementation on school environments. Method: six focus groups were carried out grouping 50 key actors linked to educational establishments using a non-probabilistic sample. A content analysis was applied through thematic coding technique seeking to reveal emerging semantic universes. Results: Nine barriers, or semantics, were identified characterizing limitations to healthy eating habits in school environments: family, school kiosks, leaving school establishments, taste, socioeconomic determinants, public policy, lack of knowledge, publicity, and availability of products without seals. Conclusions: limitations associated with domestic food environment have a significantly high representation (47,9%) and contain an individualized responsibility feature. This explanatory culture is opposed to scientific and academic evidence regarding the functioning of eating behavior, and the centrality of food environments facilitating or hindering healthy food consumption.

Establishment and Application of a 42-plex Microhaplotype Assay in Forensic Genetics / 法医学杂志

Objective To establish and forensically verify a 42 microhaplotypes(mircohaps,MHs)mul-tiplex assay system based on next-generation sequencing(NGS),and to explore the application value of this system in the practice of forensic genetics.Methods A total of 42 highly polymorphic MHs were selected from previous studies,and sequenced by the MiSeq FGxTM platform to verify the repeata-bility,sensitivity,specificity,stability,and mixture analysis ability of the detection system.Through population genetic investigation of 102 unrelated Chinese Han individuals in Liyang City,Jiangsu Province,China,the application value of this system in forensic genetics was evaluated.Results The sequencing repeatability of the 42-plex MHs assay was 100%and the sensitivity was as low as 0.062 5 ng.The system had the ability to withstand the interference of indigo(≤2 500 ng/μL),humic acid(≤9 ng/μL),hemoglobin(≤20 μmol),and urea(≤200 ng/μL)and to detect mixtures of 2 people(1∶19),3 people(1∶1∶9)and 4 people(1∶1∶1∶9).Based on 102 individual data,the combined power of discrimination and the combined power of exclusion were 1-3.45×10-30 and 1-3.77×10-11,respectively,and the average effect value of alleles was 2.899.Conclusion The 42-plex MHs assay was successfully established in this study and this system has high repeatability and sensitivity,good anti-jamming ability and mixture analysis ability.The 42 MHs are highly polymorphism and have good application value in individual identification and paternity testing.

Research Progress on Biological Evidence Identification in Fire Scenes / 法医学杂志

Biological evidence is relatively common evidence in criminal cases,and it has strong pro-bative power because it carries DNA information for individual identification.At the scene of fire-related cases,the complex thermal environment,the escape of trapped people,the firefighting and res-cue operations,and the deliberate destruction of criminal suspects will all affect the biological evi-dence in the fire scene.Scholars at home and abroad have explored and studied the effectiveness of biological evidence identification in fire scenes,and found that the blood stains,semen stains,bones,etc.are the main biological evidence which can be easily recovered with DNA in fire scenes.In order to analyze the research status and development trend of biological evidence in fire scenes,this paper systematically sorts out the relevant research,mainly including the soot removal technology,appearance method of typical biological evidence,and possibility of identifying other biological evidence.This pa-per also prospects the next step of research direction,in order to provide reference for the identifica-tion of biological evidence and improve the value of biological evidence in fire scenes.

The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application / 法医学杂志

In recent years,with the continuous progress of DNA extraction and detection technology,cell-free DNA(cfDNA)has been widely used in the life science field,and its potential application value in forensic identification is becoming more and more obvious.This paper reviews the concept,formation mechanism,and classification of cfDNA,etc.,and describes the latest research progress of cfDNA in personal identification of crime scene touch DNA samples and non-invasive prenatal pater-nity testing(NIPPT).Meanwhile,this paper summarizes the potential application of cfDNA in injury inference,and discusses the advantages and disadvantages of common cfDNA analysis methods and techniques,and its application prospects,to provide a new idea for the wide application of cfDNA in the field of forensic science.

Effect of dynamic lung compliance-guided individual positive end-expiratory pressure titration on pulmonary function in elderly patients undergoing laparoscopic colorectal cancer surgery / 临床麻醉学杂志

Objective To investigate the effects of dynamic lung compliance(Cdyn)-guided indi-vidual positive end-expiratory pressure(PEEP)titration on pulmonary function in elderly patients undergoing laparoscopic colorectal cancer surgery.Methods Sixty-eight elderly patients were selected for laparoscopic radical resection of colorectal cancer,37 males and 31 females,aged 65-79 years,BMI<30 kg/m2,ASA physical status Ⅱ or Ⅲ.The patients were divided into two groups using the random number table method:individualized PEEP group(group P)and control group(group C),34 patients in each group.In group P,the patients received recruitment maneuvers and PEEP titration test at immediately after intubation,immediately after establishing pneumoperitoneum-Trendelenburg position and immediately after pneumoperitoneum.The patients in group C received PEEP 5 cmH2 O during procedure.The three best titra-tion PEEP and the actual tidal volume(VT)in group P were also recorded.PaO2,PaCO2,PETCO2 10 mi-nutes after the tracheal intubation(T1),10 minutes(T2)and 1 hour(T3)after establishing pneumoperito-neum-Trendelenburg position,at the end of the surgery but before extubation(T4)were recorded,and the oxygenation index(OI),physiological dead space to tidal volume(Vd/VT),alveolar arterial oxygen differ-ence(A-aDO2),driving pressure,and Cdyn were calculated.Concentrations of interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),Clara cell secretoyr protein(CC16)and lung alveolar surface active sub-stances-D(SP-D)in the serum samples were determined by ELISA before anesthesia induction(T0)and 10 minutes after extubation(T5).Postoperative pulmonary complications(PPCs)were also recordrd.Results The individualized PEEP of Cdyn?guided PEEP titration was 4 cmH2O. Compared with group C, the PaO2 and OI in group C were significantly increased at T4, the Cdyn was significantly increased at T1,T3, and T4, the driving pressure was significantly decreased at T1 -T4, the serum concentration of CC16 was significantly decreased at T5 ( P < 0. 05). There were no significant differences in PaCO2, PET CO2,A?aDO2, and Vd/ VT between the two groups. There was no severe PPCs in the two groups. Conclusion Pressure?controlled ventilation modes combined with Cdyn?guide PEEP titration can increase the Cdyn, reduce thedriving pressure, and improve OI at the end of the operation, reduce the concentrations of CC16 at postop?eration, improve pulmonary function in elderly patients undergoing laparoscopic colorectal cancer surgery.

A dosimetric study of 3D-printed individual phantom in intensity modulated radiation therapy plan for chest / 中国医学装备

Objective:To make an individual phantom that was printed by using three dimension(3D)technique,which could reflect the real situation of patient,and to analyze the computed tomography(CT)value and dose distribution of radiotherapy on each organ of the inside of the 3D-printed individual phantom.Methods:According to the localization of CT image of the patient,the empty shell of 3D structure of each organ were reconstructed and printed by using 3D technique.The CT value was used as basis to select the equivalent material of each organ to perform fill,which could obtain the individual phantom of chest that could appear the structural characteristics of patient.The treatment plan of patients were included in treatment plan group,and the plans which were transplanted to 3D-printed individual phantom from treatment plan of patients were included in phantom plan group.The dosimetric parameters of the plans of two groups were compared.Results:The average CT values of left and right lung,soft tissue,cancellous bone,compact bone and heart of the phantom plan group were respectively-709,-737,14,144,760 and 28 HU.The errors of the all CT values between phantom images and located images of patients were less than 16.7%.The exposure doses of normal tissues of radiotherapy plans on the images of two groups could meet the clinical requirements.The minimum dose(Dmin),mean dose(Dmean),the corresponding doses of 98%,50% and 2% target volumes(D98%,D50% and D2%),conformity index(CI),homogeneity index(HI),monitor unit(MU)of dosimetric parameters of the target region could meet the clinical requirements without statistically significant differences.There was significant differences in the maximum dose(Dmax)of the target region(t=2.678,P＜0.05).Among of these Dmax values,the Dmax value of phantom plan group was larger,which was(56.97±0.32)Gy.Conclusion:The CT value,tissue structure and spatial distribution of the phantom,which is finally designed,can emulate the chest of human body in radiotherapy.It has verified the feasibility that 3D-printed phantom is applied in measuring dose in the quality assurance of radiotherapy.

Clinical Experience of Dispelling Wind,Clearing Heat and Resolving Dampness in the Treatment of Post-COVID-19 Cough / 浙江中医药大学学报

[Objective]To summarize the clinical experience of Professor WANG Zhen in the treatment of post-Corona Virus Disease 2019(COVID-19)cough.[Methods]Through the way of recording and sorting out medical cases,referring to domestic and foreign literature,this paper expounded the clinical experience of Professor WANG Zhen from three aspects:pathogenesis,prescription and medical cases.[Results]Professor WANG Zhen believes that the cause of post-COVID-19 cough is epidemic Qi,and the cause of the disease is wind and dampness-heat.The prescription experience is to dispel wind and relieve external symptoms,open the orifices and soothe the throat,clear heat and resolve dampness in tri-Jiao,and take into account both individual variability and symptoms and causes.Two medical cases are reported,the patient complained of post-COVID-19 cough,and Professor WANG Zhen mainly dispelled wind,cleared heat and resolved dampness,supplemented by nourishing Yin,invigorating the spleen,tonifying the kidney and dispersing blood stasis,with a comprehensive prescription and accurate curative effect.[Conclusion]Professor WANG Zhen accurately grasps the pathogenesis of post-COVID-19 cough,the treatment method is clear,the use of traditional Chinese medicine is rational,the therapeutic effect is obvious,and his clinical experience is valuable.

A Methodological Investigation of Hair Proteomics-based Differentiation of Individual Traits / 生物化学与生物物理进展

ObjectiveHair is an essential skin appendage, primarily composed of keratins and keratin-associated proteins. The protein composition and proportion of hair samples vary among different races and sexes. Currently, there is a lack of efficient methods to extract hair proteins. This study aims to explore the application of quantitative hair proteomics in distinguishing individual hair characteristics. MethodsBased on the exploration of sample processing and lysis buffer using three hair samples, we developed a stable and efficient hair protein extraction method, named PLEE (PTM lab for protein extraction from hair with high efficiency). We used the PLEE method to extract seven human hair samples and performed proteomic experiments on them using in-gel digestion method to produce data for analyzing hair protein composition and proportion among individuals. ResultsA total of 274 proteins were identified, among which 107 proteins were commonly present, and the number of non-common proteins ranged from 57-119, with some samples having unique identification proteins. Using the 107 commonly identified proteins for quantitative protein fractionation analysis, various samples were distinguished by clustering and principal component analysis, and technical repeated samples were merged, indicating the stability of the process. In addition, 10 key proteins (KRT33A, KRTAP9-6, KRT83, KRTAP7-1, KRT32, BLMH, KRT38, KRTAP11-1, NPAS1, KRTAP4-3) with large differences between individuals and stable protein identification within the same individual were screened. ConclusionThe protein composition of hair varies among different individuals, and the 10 selected proteins are expected to be key proteins for distinguishing individual hair characteristics and have significant potential applications in individual identification and criminal investigation.

Study progress on pharmacogenomics of sodium-glucose linked transporter 2 inhibitors / 中国药房

Sodium-glucose linked transporter 2 inhibitors（SGLT2i） are novel oral hypoglycaemic agents and are widely used for hypoglycemic therapy in patients with type 2 diabetes mellitus， but differences in the genetic backgrounds of patients often lead to variable responsiveness to drug therapy. By summarizing the pharmacogenomic studies of SGLT2i， the article found that the genetic variants of UGT1A9， UGT2B4， SLC5A2， ABCB1， PNPLA3 and WFS1 may influence the pharmacokinetics of SGLT2i and the external hypoglycemic effects of SGLT2i in improving non-alcoholic fatty liver disease， weight loss and so on， but there is no clinical evidence that genetic polymorphisms affect the hypoglycemic efficacy of SGLT2i.

Covid-19: fatores associados ao uso e adesão de equipamentos de proteção individual entre residentes no Brasil / Covid-19: factors associated with the use and adherence of personal protective equipment in Brazil among residents / Covid-19: factores asociados al uso y adherencia de equipos de protección personal entre los residentes en Brasil

Objetivo: analisar os fatores associados ao uso e a adesão aos equipamentos de proteção individual pelos profissionais pós-graduandos vinculados a programas de residência em saúde. Método: transversal com 227 residentes. Avaliadas variáveis relacionadas à adesão e uso adequado de equipamentos de proteção individual por meio de instrumento validado "E.P.I. covid-19 Brasil-versão adaptada para residentes". Realizou-se análise bivariada, teste qui-quadrado/exato de Fisher e cálculo da razão de prevalência. Pesquisa foi aprovada pelo Comitê de Ética em Pesquisa com Seres Humanos. Resultados: realizaram atividades de capacitação sobre EPIs (59,9%).Associação entre uso de máscara cirúrgica(p≤0,01) e idade; área de concentração do programa e uso de gorro (p≤0,01) e máscara cirúrgica (p=0,04); realização de atividades de capacitação e uso de máscara cirúrgica (p=0,02) e N95 (p≤0,01). A adesão variou de 0% a 67%. Conclusão: fatores associados ao uso adequado, idade, área de concentração do programa e realização de atividades de capacitação. Houve fragilidades na adesão. Sugere-se o fortalecimento do tema biossegurança na residência.

Objective: to analyze the factors associated with the use and adherence to personal protective equipment by graduate professionals linked to residency programs in health. Method: cross-sectional study with 227 residents. E.P.I.covid-19 Brasil-adapted version for residents". Bivariate analysis, Fisher chi-square/exact test and calculation of the prevalence ratio were performed. Research was approved by the Ethics Committee for Research with Human Beings. Results: they carried out training activities on PPE (59.9%). Association between use of surgical mask (p≤0.01) and age; program concentration area and use of cap (p≤0.01) and surgical mask (p=0.04); performance of training activities and use of surgical mask (p=0.02) and N95 (p≤0.01). Adherence to PPE ranged from 0% to 67%. Conclusion: factors associated with the proper use of personal protective equipment were age, area of program concentration, and performance of training activities. There were weaknesses in adherence. It is suggested to strengthen the theme of biosafety in the residence.

Objetivos:analizar los factores asociados al uso y la adherencia a los equipos de protección personal (EPP) por parte de profesionales graduados vinculados a programas de residencia en salud. Método: estudio transversal con 227 residentes. Se utilizó la versión adaptada para residentes del «Cuestionario sobre EPI en la atención primaria de salud (EPS-APS) en el contexto de la COVID-19 en Brasil. Se realizaron análisis bivariados, prueba chi-cuadrado de Fisher/prueba exacta y cálculo de la razón de prevalencia. La investigación fue aprobada por el Comité de Ética para la Investigación con Seres Humanos. Resultados: se realizaron actividades de capacitación sobre EPI (59,9%). Se observó asociación entre el uso de mascarilla quirúrgica (p≤0,01) y la edad; área de concentración del programa y uso de cofia (p≤0,01) y mascarilla quirúrgica (p=0,04); realización de actividades de capacitación y uso de mascarilla quirúrgica (p=0,02) y N95 (p≤0,01). La adherencia a los EPI osciló entre el 0% y el 67%. Conclusión: los factores asociados al uso correcto de los EPI fueron la edad, el área de concentración del programa y la realización de actividades de capacitación. Se observaron debilidades en la adherencia. Se sugiere fortalecer el tema de la bioseguridad en la residencia.

Medidas de proteção contra a COVID-19: impactos comunicativos, sociais e emocionais em usuários de aparelhos de amplificação sonora individual / Protective measures against COVID-19: communicative, social and emotional impacts on hearing aids users

RESUMO Objetivo investigar os impactos comunicativos, sociais e emocionais gerados pela adoção de medidas protetivas contra a COVID-19 e associá-los ao grau da perda auditiva e ao tempo de uso dos aparelhos de amplificação sonora individual. Métodos estudo transversal e quantitativo, com 72 indivíduos, divididos em adultos e idosos, com perda auditiva bilateral, de grau até moderadamente severo, protetizados antes da pandemia em um programa público de saúde auditiva e que mantiveram uso efetivo dos dispositivos. Os sujeitos foram convidados a participar do estudo enquanto aguardavam consulta. Os prontuários foram acessados, a fim de coletar informações sobre o perfil audiológico e adaptação/uso dos aparelhos de amplificação sonora individual. Em sala silenciosa, foi aplicado, oralmente, protocolo contendo questões objetivas e os dados foram tabulados e submetidos aos testes estatísticos Igualdade de Duas Proporções e Qui-Quadrado. Resultados nos dois grupos, um número significativo de usuários teve a comunicação impactada pelo uso de máscaras e pelo distanciamento físico, predominando, entre os adultos, a dificuldade com as tecnologias digitais (celulares/computadores), enquanto nas videochamadas, os prejuízos comunicativos foram mais experenciados pelos idosos. Os empecilhos comunicativos e sociais existiram, independentemente do perfil audiológico e do tempo de uso dos dispositivos. Quando questionados se deixaram de se comunicar e se as medidas afetaram a sua vida social, as respostas ficaram divididas entre "sim/às vezes" e "não". Quanto ao impacto emocional das medidas protetivas, constatou-se maior repercussão entre os adultos. Conclusão as medidas protetivas afetaram a comunicação dos usuários de aparelhos de amplificação sonora individual, porém, não desencorajaram as trocas comunicativas e as interações sociais de, aproximadamente, metade da amostra, sendo o impacto emocional mais evidente nos adultos. Tais dificuldades não estiveram relacionadas ao perfil audiológico e uso diário dos dispositivos.

ABSTRACT Purpose to investigate the communicative, social, and emotional impacts generated by adopting protective measures against COVID-19 and associate them with the degree of hearing loss and the time of use of hearing aids. Methods cross-sectional quantitative study, with 72 individuals, divided into adults and older adults, with bilateral hearing loss up to moderately severe degree, users of hearing aids fitted before the pandemic in a public hearing health program who had maintained effective use of the devices. The participants were invited to participate in the study while waiting for an appointment and signed the consent form. After that, medical records were accessed to collect information about audiological profiles and the fitting/use of hearing aids. Afterward, a protocol with objective questions was orally applied in a silent room. Data were tabulated and subjected to Equality of Two Proportions and Chi-Square statistical tests. Results in both groups, a significant number of users had communication impacted by the use of masks and by social distancing, with difficulty with digital technologies (cell phones/computers) predominating among adults, while older adults more commonly experienced communicative impairments during video calls. The communicative impediment existed regardless of the audiological profile and device use time. When asked if they stopped communicating and if the measures affected their social life, the sample was divided between "yes/sometimes" and "no". As for the emotional impact of protective measures, there was a greater impact among adults. Conclusion protective measures affected the communication of hearing aids users but did not discourage communicative exchanges and social interactions for approximately half of the sample, with the emotional impact being more evident in adults. Such difficulties were not related to the audiological profile and daily use of the devices.