Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome / 浙江大学学报·医学版

Two male patients with bifid rib-basal cell nevus-jaw cyst syndrome (BCNS) were admitted to Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College due to radiological findings of multiple low density shadows in the jaw. Clinical and imaging findings showed thoracic malformation, calcification of the tentorium cerebellum and falx cerebrum as well as widening of the orbital distance. Whole exon high-throughput sequencing was performed in two patients and their family members. The heterozygous mutations of c.C2541C>A(p.Y847X) and c.C1501C>T(p.Q501X) in PTCH1 gene were detected in both patients. Diagnosis of BCNS was confirmed. The heterozygous mutations of PTCH1 gene locus were also found in the mothers of the two probands. Proband 1 showed clinical manifestations of low intelligence, and heterozygous mutations of c.C2141T(p.P714L) and c.G3343A(p.V1115I) were detected in FANCD2 gene. Proband 2 had normal intelligence and no FANCD2 mutation. The fenestration decompression and curettage of jaw cyst were performed in both patients. Regular follow-up showed good bone growth at the original lesion, and no recurrence has been observed so far.

Effect of decompression combined with curettage and autogenous bone cement implantation on large cysts of the jaw / 华西口腔医学杂志

Decompression and curettage can result are effective as treatments for large jaw cysts, which are common diseases in the clinic. Based on a treatment used in a previous study, this paper proposes a "three-step method" to treat large jaw cyst and repair the bone defect by decompression, curettage, and autologous dental bone powder implantation. This paper introduces the processes and key points of the operation involved in the abovementioned method.

Glandular Odontogenic Cyst of Mandible: A Case Report.

Glandular odontogenic cysts (GOCs) are a very rare developmental cyst of the jaws. GOCs are intrabony solitary or multiloculated cyst of odontogenic origin. The importance of GOCs lies in fact that they exhibit a high propensity for recurrence. Thus, the oral physicians, radiologist, and oral pathologist play a major role in the definitive diagnosis of GOCs based on distinctive cases; though they are rare. In large part, this is due to the GOCs complex and frequently non-specific histopathology. This report describes a case of GOC occurrence in posterior mandibular angle region in a 43-year-old Irani Male, which was a rare site for its occurrence.

Survey of dental anxiety in jaw cyst patients treated by cyst plug after fenestration decompression / 第二军医大学学报

Objective To analyze the prevalence of dental anxiety in jaw cyst patients treated by cyst plug after fenestration decompression and to discuss its possible correlative factors. Methods A questionnaire survey was conducted among a total of 198 adult outpatients treated by cyst plug after fenestration decompression in our department from Mar.2012 to Dec.2014. All patients completed the Modified Dental Anxiety Scale (MDAS) to evaluate the level of dental anxiety and the related factors. The data were analyzed by SPSS 22.0 software package. Results The prevalence rate of dental anxiety in the outpatients treated by cyst plug after fenestration decompression was 63.6% (126/198) in the present study; χ2 test results showed significant differences in the prevalence rates of dental anxiety in regard to the factors of sex, age, marital status, Visual Analogue Scale (VAS) degree, and receiving initial treatment or not(P<0.05); Logistic regression analysis demonstrated that the risk factors of dental anxiety included sex, age, VAS degree, and initial treatment or not; and Spearman rank correlation analysis showed a weakly positive correlation between VAS degree and MDAS classification, and the correlation coefficient was statistically significant. Conclusion The prevalence rate of dental anxiety in jaw cyst patients treated by cyst plug after fenestration decompression is high. Dental anxiety is closely associated with sex, age, marital status, VAS degree, and being initial treatment or not; and a positive correlation is found between the cyst fenestration decompression pain degree and the MDAS anxiety level.

Endoscopic-assisted Enucleation of Radicular Cysts — A Case Report

The standard management for the majority of benign jaw cysts is enucleation, marsupialisation, curettage and decompression. Enucleation has the advantage that the whole specimen is sent for microscopic evaluation so that more sinister pathological processes (i.e. squamous cell carcinoma) may not be missed. In a large cystic lesion, enucleation is still possible, but technical difficulties might be encountered. In such instances, inevitable damage can occur to the surrounding structures. We report a case of a large radicular cyst of the maxilla that was enucleated via endoscopic assistance through the Caldwell Luc approach.