Investigation and analysis of Chinese public 's cognition for clinical research / 中南大学学报(医学版)

OBJECTIVES@#Clinical research plays a vital role in disease research and population health. The public is the main source of clinical research volunteers. Understanding the public's cognition of clinical research plays a decisive role in the development of clinical research. This study aims to understand the Chinese public's cognition for clinical research and the influencing factors.@*METHODS@#The questionnaire based on Chinese-translated Public Awareness of Research for Therapeutic Advancements through Knowledge and Empowerment (PARTAKE) was used to investigate the public's cognition for clinical research.@*RESULTS@#Of the 2 513 valid respondents, 91.84% had heard of "clinical research", 91.76% of the respondents believed that clinical research was beneficial to society, 65.90% were willing to participate in clinical research, 87.50% believed that confidentiality was a very important thing, 73.70% believed that their personal information had been protected when participating in clinical research, and, 46.40% did not know whether volunteers participating in clinical research could receive adequate compensation. Educational levels, employment status, and annual income impacted in public perceptions of willingness to participate in clinical research, especially in privacy protection, informed consent, whether clinical research is intended for society, compensation for clinical research, and safety of clinical research (all P<0.01).@*CONCLUSIONS@#The Chinese public's cognition level for clinical research is acceptable, but there is still a lot of room for improvement in privacy protection, informed consent, and compensation. By designing a reasonable knowledge training program for clinical research and using the multimedia, improving access to the relevant knowledge, more public will know about clinical research recruitment information, which is of great significance for the development of clinical research in China.

Influence of popularizing relevant knowledge on voluntary blood donation of patients′ families: in terms of knowledge, attitude and practice / 中国输血杂志

【Objective】 To investigate the influence of knowledge popularization concerning blood donation and blood use on the knowledge, attitudes and practice(KAP) of voluntary blood donation of patients′ families. 【Methods】 Knowledge popularization on voluntary blood donation and clinical blood use was conducted to family members of tumor patients. A questionnaire was designed according to KAP theory to capture the general situation, blood donation history and demographic characteristics of patients′ family members, their knowledge on blood donation and clinical blood use, as well as their intention, attitude and behavior changes on voluntary blood donation before and after popularization. 【Results】 13.49%(104/771) of the family members of tumor patients donated, and most of them aged 28~37 years old(19.7%, 26/132). The awareness rate of patients′ family members on voluntary blood donation and clinical blood use after popularizing was significantly increased as compared with before(P<0.05). Especially, the awareness rate of "blood transfusion significance and the risk of infectious diseases", and " patients were given priority to use blood if their family members donated blood" increased to 61.35%(473/771) and 68.74%(530/771), respectively.Their intention, attitude and behavior of blood donation also changed significantly(P<0.05). The intention of supporting voluntary blood donation increased to 78.21%(603/771), and non-supporting decreased to 4.15%(32/771). Such three behaviors led to a donation rate higher than 70% as donating for charity and sense of responsibility(74.06%, 571/771), donating blood after reassuring(70.69%, 545/771), and promoting their family members′ priority in blood use(71.47%, 551/771). 【Conclusion】 The popularization of knowledge concerning blood donation and blood use can change the intention and attitude of patients′ family members towards voluntary blood donation and further effectively promote their donation behavior.