RESUMO
Objective: To establish a scoring formula of liver injury (SFLI) using matter-element analysis, so as to provide evidence for preoperative assessment and treatment of patients with liver cirrho sis diseases. Methods: The preoperative serum biochemical indicators of liver cirrhosis patients were collected, including albumin (ALB), prealbumin (PA), total bilirubin (TBIL), serum creatine (SCr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP), prothrombin time (PT), prothromb in time-international normalized ratio (PT-INR),activated partialthromboplastin time (APTT), and thrombin time (TT). The matter-element analysis was used to establish SFLI, and the results were compared with those of Child liver function system to create SFLI scores. Results: An SFLI was successfully established. The scores of cirrhosis extents were expressed as the R value, which gradually decreased with the aggravation of cirrhosis. R = 1 represented the normal liver tissue; 0. 770≤R
RESUMO
Objective: To establish a scoring model for liver cirrhosis disease (SLCD) in experimental rats, so as to provide evidence for early clinical prevention and treatment of liver cirrhosis diseases. Methods: The liver cirrhosis model was induced in rats by composite factor method. The damages of hepatic tissues and the changes of serological liver function were observed in different phases of the rat liver cirrhosis model. The SLCD formula was obtained using the Master-Element Analysis method. Results: The experimental liver cirrhosis model was successfully established in rats. The experimental rat SLCD and SLCD formula were successfully constructed using the following 6 parameters, the age, total bilirubin, albumin, prealbumin, prothrombin time-international normalized ratio, and serum creatinine. The score was expressed as the R value, which gradually decreased with the aggravation of lesion and fibrosis. R=1: the liver tissue was normal; 0.702 ≤ R < 1: there were inflammatory reaction, focal degeneration and necrosis in the liver; 0.542 ≤ R < 0.702: there was fibroplasia in the liver; 0.352 ≤ R < 0.542: pseudolobules were formed, and it was in the liver cirrhosis stage; and R<0.352: it was in the later stage of liver cirrhosis. Conclusion: The SLCD model can sensitively and accurately display the liver impairment and liver function reserve during experimental liver cirrhosis in rats. It may help the early prevention, diagnosis and treatment of the cirrhosis diseases if relevant clinical evidence is obtained.
RESUMO
To propose a new pattern for quality control and evaluation of Chinese materia medica(CMM).The limitation of quality control pattern for CMM was investigated and a new method for quality evaluation has been explored and designed,combining with the introduction on the conception of matter-element evaluation model and its application to product quality evaluation in value engineering,as well as the research survey on the spectrum-activity relationship of CMM.The new method for quality evaluation referred to the results of research concerning the spectrum-activity relationship of CMM.Taking the quality grade,quality index,and chemical composition of CMM as matter-elements,the evaluated grades and tested data were normalized to establish the matter-element model.With the establishment of the improved quality control method,which is in accordance with the basic characteristics of CMM,it is expected that the safety,efficiency,and quality stability of CMM could be ensured and a new scientific research strategy and technological support could be provided to promote the modernization of CMM.