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1.
Chinese Journal of Biochemical Pharmaceutics ; (6): 13-17, 2017.
Artigo em Chinês | WPRIM | ID: wpr-510139

RESUMO

Objective To prepare thermosensitive chitosan (CTS) hydrogels containing astragalus polysaccharides (APS)/CTS microshperes (MS), and evaluate its physicochemical properties. Methods The APS/CTS MS (APS-MS) were prepared by spray drying method, and characterized by Scanning Electron Microscopy (SEM) and Laser Granularity Analyzer. Depending on the gelation temperature and gelating time, thermosensitive CTS hydrogels (HG) containing APS-MS (APS-MS-HG) were optimized by signal factor experiments, and the morphological characteristics were observed by SEM. In vitro release behaviors of APS-MS, hydrogels containing APS (APS-HG) and APS-MS-HG in pH 6.8 phosphate buffer were evaluated by dialysis tube method. Results The APS-MS were well dispersed with nearly spherical shapes and slightly wrinkled surfaces. The surface weighted mean D[3,2] of APS-MS was 8.078μm. The optimal APS-MS-HG, APS-MS-HG J, contained 3.012% APS-MS which were agitated with a magnetic stirrer for 3h. Observed by SEM, APS-MS were stayed spherical and dispersed unevenly in HG J, but the porous structure of HG J was disappeared in APS-MS-HG J. The release of APS from APS-MS-HG J was without initial burst release, and the cumulative amount of APS was about 74.75% after 36h. Conclusion Suppressing the phenomenon of sudden release at the first stage of delivery, APS-MS-HG J holds great promise for topical applications as a sustained-release nasal delivery system.

2.
Academic Journal of Second Military Medical University ; (12)1985.
Artigo em Chinês | WPRIM | ID: wpr-558884

RESUMO

Objective:To prepare levofloxacin-carboxymethyl-chitosan(LVFX/CMC) microspheres and to study their colon-targeted release in rats.Methods: KromasilRKR100-5C18(250 mm?4.6 mm)was used as the analytical column and the temperature was maintained at 50℃.The mobile phase consisted of a mixture of acetonitrile:0.1% trifluoroacetic acid(2080) pumped at a flow rate of 1.0 ml/min,with ?_(ex)295 nm and ?_(em)495 nm.Sixty healthy male SD rats were randomized into 2 groups: to receive gastric lavage with normal LVFX(40 mg,control group) and LVFX/CMC microspheres(40 mg,treatment group).HPLC was used to detect the concentrations of LVFX in the stomach,intestine,cecum,colon and blood in rats in both groups.Results: LVFX was detectable 3 h after LVFX/CMC microsphere lavage.Five hours after lavage,the levels of LVFX in cecum and colon were respectively(3.394?0.197) mg and(1.873?0.216) mg in treatment group,and(0.489?0.123) mg and((0.078?0.002)) mg in control group(P

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