Subdiaphragmatic vagotomy induces NADPH diaphorase in the rat dorsal motor nucleus of the vagus

Axotomy of the vagal motor neurons by cervical vagotomy induces NADPH diaphorase staining due to increased nitric oxide synthase expression in both the rat dorsal motor nucleus and nucleus ambiguous; furthermore, cerical vagotomy leads to cell death of the dorsal motor nucleus cells. Subdiaphragmatic vagotomy axotomizes the vagal motor cells further from the brainstem than cervical vagotomy, and cuts the fibers running only to the abdominal viscera. Here we report that subdiaphragmatic vagotomy is sufficient to induce NADPH diaphorase staining in the dorsal motor nucleus but does not induce staining in the nucleus ambiguus. Because the neurons of the dorsal motor nucleus do not undergo cell death after subdiaphragmatic vagotomy and are able to re-enervate the gut, the increased nitric oxide synthase expression after distal axotomy may be related more to regeneration than degeneration.

Serum nitric oxide level in the patients with oral squamous cell carcinoma and its change after operation / 中国癌症杂志

Purpose:To study the serum nitric oxide level and changes before and after operation in patients with oral squamous cell carcinoma.Methods:Serum NO and nitric oxide synthase(NOS) in 41 patients with oral squamous cell carcinoma,31 cases of benign diseases and 20 healthy coutrol were measured by chemical photometry.Results:In oral squamous cell carcinoma group,the serum NO and NOS level were significantly higher than in benign diseases and healthy control group ( P