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Introduction: Simple febrile convulsion is the most common central nervous system disease seen in children. There are hypotheses that thresh hold of neuron excitation may be affected by iron deficiency anemia. Febrile seizures are convulsions that occur in a child who is between six months and five years of age and has a temperature greater than 100.4ºF (38ºC). The majority of febrile seizures occur in children between 6 months to 3 years of age. The aim of the study: The purpose of this study was to determine the association between iron deficiency and febrile seizures in a large cohort of children who are admitted to the paediatric ward. Materials and methods: The study was conducted in 100 children those concerned parents who are willing to participate in the study at Sree Balaji medical college and hospital, Chennai. Children were categorized into 2 groups. Group, I control group (n=50) admitted with febrile illness (fever duration < 3 days) including respiratory infections or acute gastroenteritis but without seizures and without iron supplements. Group II case group (n=50) admitted with febrile illness (fever duration < 3 days) including respiratory infections or acute gastroenteritis but with seizures and with iron supplements. Both the genders are in taken for the study. Parameters such as height, weight, BMI, body temperature, Hb, MCV, serum ferritin were analyzed using standard techniques and results were analyzed accordingly. Results: The age group, height, and weight didn’t show any specific variations which were found to less statically significant of p value<0.005. The mean hemoglobin level, MCV, MCH, serum ferritin level was found to be more in of Group I control group when compared to Group II case group of pvalue <0.001**which was found to be more statically significant. E. Dinesh Kumar, Thumjaa Annamalai. Correlation of iron deficiency anemia and events of febrile seizures among children aged 6 months to 5 years. IAIM, 2017; 4(11): 196-201. Page 197 Conclusion: Children with febrile seizures are almost twice as likely to have iron deficiency anemia as compared to children with febrile illness without seizures. Iron deficiency anemia can be regarded as a modifiable risk factor that predisposes to febrile seizures in children between 6 months to 5 years. Early detection and timely correction of iron deficiency may help in preventing simple febrile seizures in children of this age group
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Objective To explore different doses of recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolytic therapy for acute cerebral infarction.Methods 130 patients with acute cerebral infarction were as the research subjects selected from May 2014 to May 2015 for rt-PA thrombolytic therapy, who were divided into two groups according to rt-PA thrombolytic agent dose, 65 cases in each group.Evaluated the clinical efficacy of thrombolytic therapy after treatment in accordance within 24 h intracerebral hemorrhage (ICH) , symptomatic intracerebral hemorrhage (SICH) , other bleeding symptoms and for 3 months after treatment the prognosis was good rate, total mortality.For pre-treatment, the degree of defect nerve function after two groups of patients were scored by NIHSS score, correlation analysis between the two groups of clinical efficacy and function of the degree of nerve defect before treatment.Results 3 months after thrombolysis total mortality in the standard dose group was significantly higher than that in the low-dose group (P<0.05) .After treatment, both groups NIHSS scores were significantly lower than before treatment (P<0.05); After treatment, NIHSS score 4-8 points in the proportion of low-dose group was significantly more than that in the standard dose group (P<0.05); NIHSS score 9-16 points, 17-24 points in the proportion of low-dose group were significantly less than that in the standard dose group (P<0.05).NIHSS9-16 points of patients after total mortality three months in the standard-dose group was significantly higher than that in the low-dose group (P<0.05) . Conclusion Different doses of rt-PA thrombolytic therapy in acute cerebral infarction are basically the same, and the degree of neurological deficit does not affect the efficacy, but reduce mortality in patients 3 months after low-dose rt-PA treatment, it is worth widely used in clinical practice.