Estudo comparativo duplo-cego da eficácia e segurança do cilazapril comparadas à nifedipina "retard" no tratamento da hipertensäo arterial leve e moderada / Double-Blind Comparative Study of Efficacy and Safety of Cilazapril Compared to Nifedipine Retard in the Treatment of Mild and Moderate Hypertension

PURPOSE--To evaluate the antihypertensive efficacy and safety of cilazapril compared to nifedipine retard in mild to moderate hypertension. METHODS--forty randomized out-patients with mild moderate hypertension, diastolic pressure (DP) between 95 and 115 mmHg, with placebo for 15 days were randomized and allocated for treatment, double-blind, once daily with cilazapril 2.5 mg (n = 20) or nifedipine retard 20 mg (20 = n) for four weeks. The non-responders (DP > 90mmHg) had the dosage increased twice, b.i.d., while responders were maintained up to 10 weeks. Clinical visits were performed before, at baseline and every two weeks and the laboratory test was performed after placebo run-in, 4th and 10th weeks of treatment. RESULTS--The blood pressure (BP) were similar between groups at the end of the placebo (cilazapril 151 +/- 14/103 +/- 5 - nifedipine 157 +/- 17/108 +/- 7mmHg, p > 0.05). DP decreased already at second weeks (cilazapril 95 +/- 9 - nifedipine 96 +/- 11mmHg, p < 0.05, compared to week 0) in both groups at the end of study with no difference inter groups. BP normalization was obtained in 58 per cent of the patients with cilazapril and in 61 per cent in the nifedipine group. Adverse biochemical effects were not observed in any group. Six (16 per cent) patients of the cilazapril and 15 (39per cent) of nifedipine related collateral events, although no difference were observed between groups. CONCLUSION--Cilazapril 2.5 to 25mg normalized BP in 58 per cent of mild and moderate hypertension patients, and this efficacy was similar to sustained-release nifedipine 20 to 40mg. Cilazapril had no adverse effects on the biochemical parameters with low incidence of collateral effects

Efficacy and safety of cilazapril versus nifedipine retard in essential hypertension.

A double-blind study of cilazapril (ACE inhibitor) versus nifedipine retard (calcium antagonist) in the treatment of 18 (10 on cilazapril and 8 on nifedipine) mild to moderate essential hypertensive patients (diastolic B.P. 95-115 mmHg) was performed. Both drugs were effective in lowering blood pressure to satisfactory levels by using cilazapril 2.5-5 mg once daily and 20 mg twice a day of nifedipine retard for 10 weeks. There were no adverse effects on hematological or biochemical parameter studies and no other side-effect, especially cough which is usually attributed to the ACE inhibitor therapy. This study showed that cilazapril, a new once daily ACE inhibitor, and nifedipine are safe and effective antihypertensive agents.