The effect of propofol different areas of brain cortex under intravenous propofol anesthesia as studied by EEG non-linear analysis / 解放军医学杂志

Objective To study effect of propofol on different areas of brain cortex under total intravenous propofol and fentanyl anesthesia. Methods 20 patients were randomly divided into propofol 8mg/(kg?h) group (n=10) and 10mg/(kg?h) group (n=10). The anesthesia was maintained by total intravenous propofol and fentanyl anesthesia. The EEG non-linear parameters, i.e. approximate entropy (ApEn)and correlation dimension (D 2), were recorded during perioperative periods. BP, HR, SpO 2 were monitored routinely. Results Compared with that at entry of OR, the EEG activities of frontal, parietal, and temporal cortices after anesthesia were more inhibited than that of other areas in both groups. Also EEG non-linear parameters were lower significantly after anesthesia in both groups compared with those at entry of OR (P

The study of brain distribution of propofol and memory alteration under intravenous propofol combined anesthesia by EEG non-linear analysis / 解放军医学杂志

Objective To study the brain distribution of propofol and its effect on memory under intravenous combined anesthesia. Methods 20 patients undergoing elective abdominal abdomen and limb operations were randomly divided into propofol 8mg?kg -1 ?h -1 group (n=10) and 10mg?kg -1 ?h -1 group (n=10). The perioperative EEG non-linear topographic map of approximate entropy was recorded. The perioperative patients' memory was estimated by process dissociation procedure (PDP) after operation. Results Comparing with pre-operative examination results, the intra-operation explicit and implicit memory markedly declined in both propofol 8mg?kg -1 ?h -1 group and 10mg?kg -1 ?h -1 group. There was statistically significant difference between the pre-operative and intra-operative explicit and implicit memory (P