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ObjectiveTo observe the clinical effect of modified Baqia Baweitang on diabetic foot due to dampness-heat toxicity. MethodOne hundred and four patients were randomized into control and observation groups （52 cases）. The control group was treated with epalrestat combined with Compound Huangbai Liquid， and the observation group with modified Baqia Baweitang on the basis of the therapy in the control group. The resting pain， intermittent claudication， foot cold feeling， traditional Chinese medicine （TCM） symptoms， ulcer area， ulcer surface pH， ulcer depth， and percutaneous oxygen partial pressure were measured before and after treatment. The blood glucose and lipid levels ［fasting blood glucose （FPG）， 2 h postprandial blood glucose （2 h PG）， triglyceride （TG）， and total cholesterol （TC）］， hemorheological indexes （peak blood flow， blood flow， vascular diameter， and pulse index）， motor and sensory nerve conduction velocity， and inflammatory cytokines ［tumor necrosis factor-α （TNF-α）， interleukin （IL）-6， IL-13， and C-reactive protein （CRP）］ in the serum and skin lesions were determined. The clinical efficacy and safety were compared between the two groups. ResultThe total response rate in the observation group was 96.2% （50/52）， which was higher than that （80.8%， 42/52） in the control group （χ2=6.029， P<0.05）. The treatment in both groups decreased the resting pain， intermittent claudication， foot cold feeling， TCM symptom scores， ulcer area， ulcer surface pH， and ulcer depth （P<0.05） and increased the percutaneous oxygen partial pressure （P<0.05）. Furthermore， the treatment lowered the levels of FPG， 2 h PG， TG， TC， blood flow peak， TNF-α， IL-6， IL-18， and CRP （P<0.05） and increased the blood flow， vascular diameter， pulse index， and the motor and sensory nerve conduction velocity （P<0.05）. Moreover， the changes in the above indexes were more significant in the observation group than in the control group （P<0.05）.The incidence of adverse reactions was 21.2% （11/52） in the control group and 23.1% （12/52） in the observation group， with no statistical significance. ConclusionModified Baqia Baweitang can promote wound healing， improve the dorsal artery hemorheology of feet， accelerate nerve conduction， and reduce inflammation in the patients with diabetic foot due to dampness-heat toxicity.
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Objective To observe the clinical therapeutic effect of Danhong injection combined with edaravone for treatment of patients with acute cerebral infarction. Methods A prospective study was conducted. Two hundred and ten patients with acute cerebral infarction admitted to Traditional Chinese Medicine Hospital of Qinghai Province from June 2008 to January 2014 were divided into control group and observation group according to random number table method, 105 cases in each group. The conventional routine treatment and edaravone injection were given to the two groups, and additionally in the observation group, intravenous drip of Danhong injection 30 mL, once a day was applied, the therapeutic course in the two groups being 14 days. The changes of blood rheology, blood fat, the United States National Institutes of Health Stroke Scale (NIHSS) scores before and after treatment and clinical curative effect were observed in two groups. Results Compared with those before treatment, plasma viscosity, fibrinogen (Fib), erythrocyte hematocrit (HCT), total cholesterol (TC), triacylglycerol (TG),and NIHSS scores were decreased in the two groups after treatment, the decrease of the above indexes in observation group being more marked [plasma viscosity (mPa·s): 1.54±0.62 vs. 3.10±0.58, Fib (g/L): 3.87±0.91 vs. 4.81±1.31, HCT: 0.46±0.04 vs. 0.54±0.05, TC (mmol/L): 4.97±1.73 vs. 6.65±1.62, TG (mmol/L): 5.01±1.25 vs. 7.53±1.23, NIHSS scores: 2.31±1.15 vs. 10.23±2.21, all P<0.05];the statistical significant differences were found in the above indexes between observation group and control group after treatment [plasma viscosity (mPa·s ):1.54±0.62 vs. 3.01±0.72, Fib (g/L):3.87±0.91 vs. 4.68±1.37, HCT:0.46±0.04 vs. 0.52±0.04, TC (mmol/L):4.97±1.73 vs. 6.34±1.71, TG (mmol/L):5.01±1.25 vs. 7.51±1.30, NIHSS score:2.31±1.15 vs. 3.75±1.73, P<0.05 or P<0.01]. The total effective rate in observation group was obviously higher than that of control group [97.14%(102/105) vs. 74.29%(78/105), P<0.01]. Conclusion The therapeutic effect of Danhong injection combined with edaravone for treatment of patients with acute cerebral infarction is significantly better than the treatment of edaravone injection alone.
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[Objective] To observe clinical therapeutic effect of combined acupuncture and acupoint thread implantation on insomnia. [Methods] The seventy two cases were randomly divided into a treatment group(37cases) and a control group(35cases).The treatment group were treated with acupuncture and acupoint thread implantation; The control group were treated with acupuncture alone. Acupuncture treatment was provided every other day,they were totally treated for 10 times;Acupoint thread implantation was provided one time every week,observe the clinicial therapeutic effect after 3 times of treatment. [Result] The effective rate on chloasma was 89.19%in the treatment group and 71.42%in the control group.The clinical effect in the treatment group was significant better than that in the control group(P<0.05). [Conclusion] Acupuncture combined with acupoint thread implantation shows a better therapeutic effect on insomnia.
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[Objective] To observe the therapeutic effect of puerain with corticosteroid on nonanterior ischmic optic neuropathy (NAION).[Methods] In 58 patients(60 eyes)who were diagnosed as NA10N,29 patients (30 eyes)underwent intravenous drip with puerain and corticosteroid (treatment group);and the other 29 patients (3o eyes)underwent intravenous drip with corticosteroid and compound anisondine (control group).[Results] The visual acuity was better in treatment group than that in control group with a significant difference (x2=4.83,P
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OBJECTIVE:To observe the therapeutic effect of fleabane in the treatment of non-arteritis anterior ischemic optic neuropathy(AION).METHODS:38non-arteritis AION patients were divided into two groups at random:group A and group B were treated with fleabane and salvia miltiorrhiza respectively.RESULTS:The eyesight of both groups has been im-proved in a different degree and the improvement of visual field of group A surpassed that of group B.CONCLUSION:Flea-bane has certain amelioration and protection effects in the treatment of non-arteritis AION.
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OBJECTIVE:To observe the therapeutic effect and adverse reactions of Carboplatin combined with Paclitaxel in treatment of NSCLC.METHODS:37patients with pathologically or cytologically proved NSCLCⅢb orⅣreceived treat?ment.Paclitaxel(150mg/m 2 )in saline iv drip for4-6h and Carboplatin(AUC6)iv drip alteratively administrated for21days.At least2therapeutic courses were carried out.RESULTS:Among37patients,3had complete remission,15partial re?mission13kept stable and6were progressive with a total effective rate of48.6%and one-year survival rate of51.3%.The common adverse reactions were muscular soreness and bone-marrow inhibition,however,most patients could tolerate the side effects.CONCLUSION:The therapeutic effect of Carboplatin and Paclitaxel on advanced NSCLC is reliable and the patients are tolerant of the side effects.
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OBJECTIVE:To study the therapeutic efficacy of Yixinkangtai capsules(YXKT)on climacteric syndrome in males.METHODS:360cases of male climacteric syndrome randomly divided into2groups:trial group(220cases)was treated with YXKT for3wks and control group(140cases)received placebo.RESULTS:In the trial group,the rate of symptomatic improvement was74.3%.Before and after3-week treatment,blood testosterone levels were(131.51?19.12)mg/L and(253.78?21.45)mg/L;SOD levels were(1068?121.4)IU/(g?Hb)and(1178.1?132.6)IU/(g?Hb),MDA levels were(7.6?0.8)?mol/L and(5.8?0.6)?mol/L respectively,and depression score was improved as well.There were significant dif?ferences in all above-mentioned parameters between2groups.CONCLUSION:YXKT is effective and safe for treating cli?macteric syndrome in males.