RESUMO
Purpose: To report the diurnal variation in choroidal vascularity index (CVI) in subfoveal (SF-CVI) and peripapillary area in healthy eyes. Methods: The study was a cross-sectional study including 12 healthy subjects. Swept-source optical coherence tomography scans were taken at 9 am, 11 am, 1 pm, 3 pm, and 5 pm. Subfoveal choroidal thickness (SFCT) and CVI were calculated using automated segmentation techniques and previously validated algorithms. Systemic parameters including systolic blood pressure (SBP), diastolic blood pressure, mean arterial pressure, and mean ocular perfusion pressure were calculated and correlated with SFCT and CVI. Results: A total of 12 eyes (right eye) of 12 patients (mean age: 26 ± 3.77 years) were analyzed. The mean (±standard deviation) amplitude of SFCT and SF-CVI variation was 35.91 ± 14.8 ?m (range, 15–69 ?m) and 0.05 ± 0.02 (range, 0.02–0.08). The mean CVI showed a significant diurnal variation in the temporal quadrant of the peripapillary region (P = 0.02). Conclusion: SFCT and SF-CVI showed a significant diurnal variation in amplitude (peak–trough analysis) and SF-CVI correlated well with SBP suggestive of a direct influence of blood pressure on choroidal vascularity. The mean peripapillary CVI in the temporal quadrant also showed a significant diurnal variation with no significant change in other quadrants.
RESUMO
PURPOSE: To evaluate the relationship between optic disc and retinal nerve fiber layer (RNFL) measurements obtained by Heidelberg retina tomography (HRT) and Optical coherence tomography (OCT) in normal and primary open angle glaucoma (POAG). METHODS: Thirty normal and 100 POAG subjects who met inclusion and exclusion criteria were evaluated retrospectively. Complete ophthalmologic examination, HRT, OCT, and automated perimetry were performed. RESULTS: In POAG group, rim area was significantly correlated with superior and inferior RNFL thickness (p<0.05), and cup shape measure was correlated with mean, superior, inferior, temporal RNFL thickness (p<0.05). Inferior RNFL thickness was correlated with many HRT parameters (cup area and cup/disc ratio, rim area, cup volume, rim volume, cup shape measure, mean RNFL thickness) and visual field index (MD and CPSD) (p<0.05). CONCLUSIONS: Inferior RNFL thickness measured by OCT was correlated with optic disc parameters and visual field index measured by HRT and automated perimetry. It may be used as indicator of glaucomatous optic disc change and visual field defect. These findings suggest that optic disc parameters and RNFL thickness measured by HRT and OCT may be helpful in diagnosing glaucoma.